Sub-Clinical Cognitive Decline and Resting Cerebral Blood Flow in Middle Aged Men

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Standard

Sub-Clinical Cognitive Decline and Resting Cerebral Blood Flow in Middle Aged Men. / Henriksen, Otto Mølby; Hansen, Naja Liv; Osler, Merete; Mortensen, Erik Lykke; Hallam, Dorte Merete; Pedersen, Esben Thade; Chappell, Michael; Lauritzen, Martin Johannes; Rostrup, Egill.

I: PLOS ONE, Bind 12, Nr. 1, e0169912, 2017.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Henriksen, OM, Hansen, NL, Osler, M, Mortensen, EL, Hallam, DM, Pedersen, ET, Chappell, M, Lauritzen, MJ & Rostrup, E 2017, 'Sub-Clinical Cognitive Decline and Resting Cerebral Blood Flow in Middle Aged Men', PLOS ONE, bind 12, nr. 1, e0169912. https://doi.org/10.1371/journal.pone.0169912

APA

Henriksen, O. M., Hansen, N. L., Osler, M., Mortensen, E. L., Hallam, D. M., Pedersen, E. T., Chappell, M., Lauritzen, M. J., & Rostrup, E. (2017). Sub-Clinical Cognitive Decline and Resting Cerebral Blood Flow in Middle Aged Men. PLOS ONE, 12(1), [e0169912]. https://doi.org/10.1371/journal.pone.0169912

Vancouver

Henriksen OM, Hansen NL, Osler M, Mortensen EL, Hallam DM, Pedersen ET o.a. Sub-Clinical Cognitive Decline and Resting Cerebral Blood Flow in Middle Aged Men. PLOS ONE. 2017;12(1). e0169912. https://doi.org/10.1371/journal.pone.0169912

Author

Henriksen, Otto Mølby ; Hansen, Naja Liv ; Osler, Merete ; Mortensen, Erik Lykke ; Hallam, Dorte Merete ; Pedersen, Esben Thade ; Chappell, Michael ; Lauritzen, Martin Johannes ; Rostrup, Egill. / Sub-Clinical Cognitive Decline and Resting Cerebral Blood Flow in Middle Aged Men. I: PLOS ONE. 2017 ; Bind 12, Nr. 1.

Bibtex

@article{85a64a01806a4aa39182c74e6937e9c8,
title = "Sub-Clinical Cognitive Decline and Resting Cerebral Blood Flow in Middle Aged Men",
abstract = "BACKGROUND: Although dementia is associated with both global and regional cerebral blood flow (CBF) changes, little is known about cerebral perfusion in the early pre-clinical stages of cognitive decline preceding overt cognitive dysfunction. The aim of this study was to investigate the association of early sub-clinical cognitive decline with CBF.MATERIALS AND METHODS: The study participants were recruited from a cohort of Danish men born in 1953. Based on a regression model we selected men who performed better (Group A, n = 94) and poorer (Group B, n = 95) on cognitive testing at age 57 than expected from testing at age 20. Participants underwent supplementary cognitive testing, blood sampling and MRI including measurements of regional and global CBF.RESULTS: Regional CBF was lower in group B than in group A in the posterior cingulate gyrus and the precuneus. The associations were attenuated when corrected for global atrophy, but remained significant in regions of interest based analysis adjusting for regional gray matter volume and vascular risk factors. No influence of group on global CBF was observed.CONCLUSIONS: We conclude that early sub-clinical cognitive decline is associated with reduced perfusion in the precuneus and posterior cingulate gyrus independently of regional atrophy and vascular risk factors, but cannot be statistically separated from an association with global atrophy.",
author = "Henriksen, {Otto M{\o}lby} and Hansen, {Naja Liv} and Merete Osler and Mortensen, {Erik Lykke} and Hallam, {Dorte Merete} and Pedersen, {Esben Thade} and Michael Chappell and Lauritzen, {Martin Johannes} and Egill Rostrup",
year = "2017",
doi = "10.1371/journal.pone.0169912",
language = "English",
volume = "12",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "1",

}

RIS

TY - JOUR

T1 - Sub-Clinical Cognitive Decline and Resting Cerebral Blood Flow in Middle Aged Men

AU - Henriksen, Otto Mølby

AU - Hansen, Naja Liv

AU - Osler, Merete

AU - Mortensen, Erik Lykke

AU - Hallam, Dorte Merete

AU - Pedersen, Esben Thade

AU - Chappell, Michael

AU - Lauritzen, Martin Johannes

AU - Rostrup, Egill

PY - 2017

Y1 - 2017

N2 - BACKGROUND: Although dementia is associated with both global and regional cerebral blood flow (CBF) changes, little is known about cerebral perfusion in the early pre-clinical stages of cognitive decline preceding overt cognitive dysfunction. The aim of this study was to investigate the association of early sub-clinical cognitive decline with CBF.MATERIALS AND METHODS: The study participants were recruited from a cohort of Danish men born in 1953. Based on a regression model we selected men who performed better (Group A, n = 94) and poorer (Group B, n = 95) on cognitive testing at age 57 than expected from testing at age 20. Participants underwent supplementary cognitive testing, blood sampling and MRI including measurements of regional and global CBF.RESULTS: Regional CBF was lower in group B than in group A in the posterior cingulate gyrus and the precuneus. The associations were attenuated when corrected for global atrophy, but remained significant in regions of interest based analysis adjusting for regional gray matter volume and vascular risk factors. No influence of group on global CBF was observed.CONCLUSIONS: We conclude that early sub-clinical cognitive decline is associated with reduced perfusion in the precuneus and posterior cingulate gyrus independently of regional atrophy and vascular risk factors, but cannot be statistically separated from an association with global atrophy.

AB - BACKGROUND: Although dementia is associated with both global and regional cerebral blood flow (CBF) changes, little is known about cerebral perfusion in the early pre-clinical stages of cognitive decline preceding overt cognitive dysfunction. The aim of this study was to investigate the association of early sub-clinical cognitive decline with CBF.MATERIALS AND METHODS: The study participants were recruited from a cohort of Danish men born in 1953. Based on a regression model we selected men who performed better (Group A, n = 94) and poorer (Group B, n = 95) on cognitive testing at age 57 than expected from testing at age 20. Participants underwent supplementary cognitive testing, blood sampling and MRI including measurements of regional and global CBF.RESULTS: Regional CBF was lower in group B than in group A in the posterior cingulate gyrus and the precuneus. The associations were attenuated when corrected for global atrophy, but remained significant in regions of interest based analysis adjusting for regional gray matter volume and vascular risk factors. No influence of group on global CBF was observed.CONCLUSIONS: We conclude that early sub-clinical cognitive decline is associated with reduced perfusion in the precuneus and posterior cingulate gyrus independently of regional atrophy and vascular risk factors, but cannot be statistically separated from an association with global atrophy.

U2 - 10.1371/journal.pone.0169912

DO - 10.1371/journal.pone.0169912

M3 - Journal article

C2 - 28095458

VL - 12

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 1

M1 - e0169912

ER -

ID: 172329351