Smoking reduction and biomarkers in two longitudinal studies

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Standard

Smoking reduction and biomarkers in two longitudinal studies. / Godtfredsen, Nina; Prescott, Eva; Vestbo, Jørgen; Osler, Merete.

I: Addiction, Bind 101, Nr. 10, 2006, s. 1516-22.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Godtfredsen, N, Prescott, E, Vestbo, J & Osler, M 2006, 'Smoking reduction and biomarkers in two longitudinal studies', Addiction, bind 101, nr. 10, s. 1516-22. https://doi.org/10.1111/j.1360-0443.2006.01542.x

APA

Godtfredsen, N., Prescott, E., Vestbo, J., & Osler, M. (2006). Smoking reduction and biomarkers in two longitudinal studies. Addiction, 101(10), 1516-22. https://doi.org/10.1111/j.1360-0443.2006.01542.x

Vancouver

Godtfredsen N, Prescott E, Vestbo J, Osler M. Smoking reduction and biomarkers in two longitudinal studies. Addiction. 2006;101(10):1516-22. https://doi.org/10.1111/j.1360-0443.2006.01542.x

Author

Godtfredsen, Nina ; Prescott, Eva ; Vestbo, Jørgen ; Osler, Merete. / Smoking reduction and biomarkers in two longitudinal studies. I: Addiction. 2006 ; Bind 101, Nr. 10. s. 1516-22.

Bibtex

@article{b30d4c60e93311ddbf70000ea68e967b,
title = "Smoking reduction and biomarkers in two longitudinal studies",
abstract = "AIMS: To measure reduction in exposure to smoke in two population-based studies of self-reported smoking reduction not using nicotine replacement. DESIGN: Cross-sectional analyses of biomarkers and smoking. SETTING: Data from two time-points in the Copenhagen City Heart Study (CCHS), 1981/83 and 1991/94, and the Copenhagen Male Study (CMS) in 1976 and 1985/86, respectively. PARTICIPANTS: There were 3026 adults who were smokers at both time-points in the CCHS and 1319 men smoking at both time-points in the CMS. MEASUREMENTS: Smoking status and tobacco consumption were assessed by self-completion questionnaire. Measurements of biomarkers of smoke intake were taken at the second time-point in the two studies: expired-air carbon monoxide (CO) in the CCHS and serum cotinine in the CMS. Biomarker levels in medium (15-29 g tobacco/day) and heavy (> 30 g/day) smokers at the first time-point who later reported a reduction in cigarettes per day of 50{\%} or more without quitting were compared with continuing medium, heavy and light smokers (1-14 g/day) using linear regression. Sex (CCHS only), age, self-reported inhalation of smoke, duration of smoking, type of tobacco and amount smoked were included as covariates in multivariate models. FINDINGS: Heavy smokers who reduced did not show lower levels of biomarkers at follow-up. Medium smokers who reduced showed a reduction in cotinine but not CO. The reduction in cotinine was not commensurate with the reported reduction in consumption. CONCLUSIONS: Long-term reductions in self-reported tobacco smoking are probably associated with, at best, modest reductions in smoke exposure.",
author = "Nina Godtfredsen and Eva Prescott and J{\o}rgen Vestbo and Merete Osler",
note = "Keywords: Adult; Aged; Aged, 80 and over; Biological Markers; Cotinine; Cross-Sectional Studies; Female; Harm Reduction; Humans; Longitudinal Studies; Male; Middle Aged; Smoking; Tobacco Smoke Pollution",
year = "2006",
doi = "10.1111/j.1360-0443.2006.01542.x",
language = "English",
volume = "101",
pages = "1516--22",
journal = "Addiction",
issn = "0965-2140",
publisher = "Wiley-Blackwell",
number = "10",

}

RIS

TY - JOUR

T1 - Smoking reduction and biomarkers in two longitudinal studies

AU - Godtfredsen, Nina

AU - Prescott, Eva

AU - Vestbo, Jørgen

AU - Osler, Merete

N1 - Keywords: Adult; Aged; Aged, 80 and over; Biological Markers; Cotinine; Cross-Sectional Studies; Female; Harm Reduction; Humans; Longitudinal Studies; Male; Middle Aged; Smoking; Tobacco Smoke Pollution

PY - 2006

Y1 - 2006

N2 - AIMS: To measure reduction in exposure to smoke in two population-based studies of self-reported smoking reduction not using nicotine replacement. DESIGN: Cross-sectional analyses of biomarkers and smoking. SETTING: Data from two time-points in the Copenhagen City Heart Study (CCHS), 1981/83 and 1991/94, and the Copenhagen Male Study (CMS) in 1976 and 1985/86, respectively. PARTICIPANTS: There were 3026 adults who were smokers at both time-points in the CCHS and 1319 men smoking at both time-points in the CMS. MEASUREMENTS: Smoking status and tobacco consumption were assessed by self-completion questionnaire. Measurements of biomarkers of smoke intake were taken at the second time-point in the two studies: expired-air carbon monoxide (CO) in the CCHS and serum cotinine in the CMS. Biomarker levels in medium (15-29 g tobacco/day) and heavy (> 30 g/day) smokers at the first time-point who later reported a reduction in cigarettes per day of 50% or more without quitting were compared with continuing medium, heavy and light smokers (1-14 g/day) using linear regression. Sex (CCHS only), age, self-reported inhalation of smoke, duration of smoking, type of tobacco and amount smoked were included as covariates in multivariate models. FINDINGS: Heavy smokers who reduced did not show lower levels of biomarkers at follow-up. Medium smokers who reduced showed a reduction in cotinine but not CO. The reduction in cotinine was not commensurate with the reported reduction in consumption. CONCLUSIONS: Long-term reductions in self-reported tobacco smoking are probably associated with, at best, modest reductions in smoke exposure.

AB - AIMS: To measure reduction in exposure to smoke in two population-based studies of self-reported smoking reduction not using nicotine replacement. DESIGN: Cross-sectional analyses of biomarkers and smoking. SETTING: Data from two time-points in the Copenhagen City Heart Study (CCHS), 1981/83 and 1991/94, and the Copenhagen Male Study (CMS) in 1976 and 1985/86, respectively. PARTICIPANTS: There were 3026 adults who were smokers at both time-points in the CCHS and 1319 men smoking at both time-points in the CMS. MEASUREMENTS: Smoking status and tobacco consumption were assessed by self-completion questionnaire. Measurements of biomarkers of smoke intake were taken at the second time-point in the two studies: expired-air carbon monoxide (CO) in the CCHS and serum cotinine in the CMS. Biomarker levels in medium (15-29 g tobacco/day) and heavy (> 30 g/day) smokers at the first time-point who later reported a reduction in cigarettes per day of 50% or more without quitting were compared with continuing medium, heavy and light smokers (1-14 g/day) using linear regression. Sex (CCHS only), age, self-reported inhalation of smoke, duration of smoking, type of tobacco and amount smoked were included as covariates in multivariate models. FINDINGS: Heavy smokers who reduced did not show lower levels of biomarkers at follow-up. Medium smokers who reduced showed a reduction in cotinine but not CO. The reduction in cotinine was not commensurate with the reported reduction in consumption. CONCLUSIONS: Long-term reductions in self-reported tobacco smoking are probably associated with, at best, modest reductions in smoke exposure.

U2 - 10.1111/j.1360-0443.2006.01542.x

DO - 10.1111/j.1360-0443.2006.01542.x

M3 - Journal article

C2 - 16968354

VL - 101

SP - 1516

EP - 1522

JO - Addiction

JF - Addiction

SN - 0965-2140

IS - 10

ER -

ID: 9908923