Sleep efficiency and neurophysiological patterns in middle-aged men are associated with cognitive change over their adult life course

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Sleep efficiency and neurophysiological patterns in middle-aged men are associated with cognitive change over their adult life course. / Waser, Markus; Lauritzen, Martin J; Fagerlund, Birgitte; Osler, Merete; Mortensen, Erik L; Sørensen, Helge B. D.; Jennum, Poul.

I: Journal of Sleep Research, Bind 28, Nr. 4, e12793, 2019.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Waser, M, Lauritzen, MJ, Fagerlund, B, Osler, M, Mortensen, EL, Sørensen, HBD & Jennum, P 2019, 'Sleep efficiency and neurophysiological patterns in middle-aged men are associated with cognitive change over their adult life course', Journal of Sleep Research, bind 28, nr. 4, e12793. https://doi.org/10.1111/jsr.12793

APA

Waser, M., Lauritzen, M. J., Fagerlund, B., Osler, M., Mortensen, E. L., Sørensen, H. B. D., & Jennum, P. (2019). Sleep efficiency and neurophysiological patterns in middle-aged men are associated with cognitive change over their adult life course. Journal of Sleep Research, 28(4), [e12793]. https://doi.org/10.1111/jsr.12793

Vancouver

Waser M, Lauritzen MJ, Fagerlund B, Osler M, Mortensen EL, Sørensen HBD o.a. Sleep efficiency and neurophysiological patterns in middle-aged men are associated with cognitive change over their adult life course. Journal of Sleep Research. 2019;28(4). e12793. https://doi.org/10.1111/jsr.12793

Author

Waser, Markus ; Lauritzen, Martin J ; Fagerlund, Birgitte ; Osler, Merete ; Mortensen, Erik L ; Sørensen, Helge B. D. ; Jennum, Poul. / Sleep efficiency and neurophysiological patterns in middle-aged men are associated with cognitive change over their adult life course. I: Journal of Sleep Research. 2019 ; Bind 28, Nr. 4.

Bibtex

@article{5f460cb5fd494291b8efd07781b0b0bb,
title = "Sleep efficiency and neurophysiological patterns in middle-aged men are associated with cognitive change over their adult life course",
abstract = "Disrupted sleep is a contributing factor to cognitive ageing, while also being associated with neurodegenerative disorders. Little is known, however, about the relation of sleep and the gradual cognitive changes over the adult life course. Sleep electroencephalogram (EEG) patterns are potential markers of the cognitive progress. To test this hypothesis, we assessed sleep architecture and EEG of 167 men born in the Copenhagen Metropolitan Area in 1953, who, based on individual cognitive testing from early (~18 years) to late adulthood (~58 years), were divided into 85 subjects with negative and 82 with positive cognitive change over their adult life. Participants underwent standard polysomnography, including manual sleep scoring at age ~58 years. Features of sleep macrostructure were combined with a number of EEG features to distinguish between the two groups. EEG rhythmicity was assessed by spectral power analysis in frontal, central and occipital sites. Functional connectivity was measured by inter-hemispheric EEG coherence. Group differences were assessed by analysis of covariance (p < 0.05), including education and severity of depression as potential covariates. Subjects with cognitive decline exhibited lower sleep efficiency, reduced inter-hemispheric connectivity during rapid eye movement (REM) sleep, and slower EEG rhythms during stage 2 non-REM sleep. Individually, none of these tendencies remained significant after multiple test correction; however, by combining them in a machine learning approach, the groups were separated with 72{\%} accuracy (75{\%} sensitivity, 67{\%} specificity). Ongoing medical screenings are required to confirm the potential of sleep efficiency and sleep EEG patterns as signs of individual cognitive progress.",
keywords = "cognitive ageing, electroencephalogram, functional connectivity, neurodegeneration, sleep efficiency",
author = "Markus Waser and Lauritzen, {Martin J} and Birgitte Fagerlund and Merete Osler and Mortensen, {Erik L} and S{\o}rensen, {Helge B. D.} and Poul Jennum",
note = "{\circledC} 2018 European Sleep Research Society.",
year = "2019",
doi = "10.1111/jsr.12793",
language = "English",
volume = "28",
journal = "Journal of Sleep Research Online",
issn = "1365-2869",
publisher = "Wiley-Blackwell",
number = "4",

}

RIS

TY - JOUR

T1 - Sleep efficiency and neurophysiological patterns in middle-aged men are associated with cognitive change over their adult life course

AU - Waser, Markus

AU - Lauritzen, Martin J

AU - Fagerlund, Birgitte

AU - Osler, Merete

AU - Mortensen, Erik L

AU - Sørensen, Helge B. D.

AU - Jennum, Poul

N1 - © 2018 European Sleep Research Society.

PY - 2019

Y1 - 2019

N2 - Disrupted sleep is a contributing factor to cognitive ageing, while also being associated with neurodegenerative disorders. Little is known, however, about the relation of sleep and the gradual cognitive changes over the adult life course. Sleep electroencephalogram (EEG) patterns are potential markers of the cognitive progress. To test this hypothesis, we assessed sleep architecture and EEG of 167 men born in the Copenhagen Metropolitan Area in 1953, who, based on individual cognitive testing from early (~18 years) to late adulthood (~58 years), were divided into 85 subjects with negative and 82 with positive cognitive change over their adult life. Participants underwent standard polysomnography, including manual sleep scoring at age ~58 years. Features of sleep macrostructure were combined with a number of EEG features to distinguish between the two groups. EEG rhythmicity was assessed by spectral power analysis in frontal, central and occipital sites. Functional connectivity was measured by inter-hemispheric EEG coherence. Group differences were assessed by analysis of covariance (p < 0.05), including education and severity of depression as potential covariates. Subjects with cognitive decline exhibited lower sleep efficiency, reduced inter-hemispheric connectivity during rapid eye movement (REM) sleep, and slower EEG rhythms during stage 2 non-REM sleep. Individually, none of these tendencies remained significant after multiple test correction; however, by combining them in a machine learning approach, the groups were separated with 72% accuracy (75% sensitivity, 67% specificity). Ongoing medical screenings are required to confirm the potential of sleep efficiency and sleep EEG patterns as signs of individual cognitive progress.

AB - Disrupted sleep is a contributing factor to cognitive ageing, while also being associated with neurodegenerative disorders. Little is known, however, about the relation of sleep and the gradual cognitive changes over the adult life course. Sleep electroencephalogram (EEG) patterns are potential markers of the cognitive progress. To test this hypothesis, we assessed sleep architecture and EEG of 167 men born in the Copenhagen Metropolitan Area in 1953, who, based on individual cognitive testing from early (~18 years) to late adulthood (~58 years), were divided into 85 subjects with negative and 82 with positive cognitive change over their adult life. Participants underwent standard polysomnography, including manual sleep scoring at age ~58 years. Features of sleep macrostructure were combined with a number of EEG features to distinguish between the two groups. EEG rhythmicity was assessed by spectral power analysis in frontal, central and occipital sites. Functional connectivity was measured by inter-hemispheric EEG coherence. Group differences were assessed by analysis of covariance (p < 0.05), including education and severity of depression as potential covariates. Subjects with cognitive decline exhibited lower sleep efficiency, reduced inter-hemispheric connectivity during rapid eye movement (REM) sleep, and slower EEG rhythms during stage 2 non-REM sleep. Individually, none of these tendencies remained significant after multiple test correction; however, by combining them in a machine learning approach, the groups were separated with 72% accuracy (75% sensitivity, 67% specificity). Ongoing medical screenings are required to confirm the potential of sleep efficiency and sleep EEG patterns as signs of individual cognitive progress.

KW - cognitive ageing

KW - electroencephalogram

KW - functional connectivity

KW - neurodegeneration

KW - sleep efficiency

U2 - 10.1111/jsr.12793

DO - 10.1111/jsr.12793

M3 - Journal article

C2 - 30417544

VL - 28

JO - Journal of Sleep Research Online

JF - Journal of Sleep Research Online

SN - 1365-2869

IS - 4

M1 - e12793

ER -

ID: 209737759