Short-term acetaminophen consumption enhances the exercise-induced increase in Achilles peritendinous IL-6 in humans

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Brian S Gump, David R McMullan, David J Cauthon, Jamie A Whitt, Jonathon D Del Mundo, Tanya Letham, Paul J Kim, Gary N Friedlander, Jessica Pingel, Henning Langberg, Chad C Carroll

Through an unknown mechanism the cyclooxygenase (COX) inhibitor acetaminophen (APAP) alters tendon mechanical properties in humans when consumed during exercise. Interleukin-6 (IL-6) is produced by tendon during exercise and is a potent stimulator of collagen synthesis. In non-tendon tissue, IL-6 is upregulated in presence of COX-inhibitors and may contribute to alterations in extracellular matrix turnover, possibly due to inhibition of prostaglandin E2 (PGE2). We evaluated the effects of APAP on IL-6 and PGE2 in human Achilles peritendinous tissue after 1-hour of treadmill exercise. Subjects were randomly assigned to a placebo (n=8, 26±1 y) or APAP (n=8, 25±1 y) group. Each subject completed a non-exercise and exercise experiment consisting of 6-hours of microdialysis. Drug (APAP, 1000 mg) or placebo was administered in a double-blind manner during both experiments. PGE2 and IL-6 were determined via enzyme immunoassay and APAP via high performance liquid chromatography. In subjects given APAP, peritendinous APAP levels increased to 4.08±0.65 μg•ml(-1) (p0.05), nor was PGE2 significantly reduced in the APAP group. IL-6 levels increased with exercise in both groups (p
TidsskriftJournal of Applied Physiology
Udgave nummer6
Sider (fra-til)929-936
Antal sider8
StatusUdgivet - 2013

Bibliografisk note

CURIS 2013 NEXS 274

ID: 46148542