Sex hormone manipulation slows reaction time and increases labile mood in healthy women

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Standard

Sex hormone manipulation slows reaction time and increases labile mood in healthy women. / Stenbæk, D. S.; Fisher, P M; Budtz-Jørgensen, E.; Pinborg, A.; Hjordt, L. V. ; Jensen, P. S.; Knudsen, G. M.; Frokjaer, V. G.

I: Psychoneuroendocrinology, Bind 68, 06.2016, s. 39-46.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Stenbæk, DS, Fisher, PM, Budtz-Jørgensen, E, Pinborg, A, Hjordt, LV, Jensen, PS, Knudsen, GM & Frokjaer, VG 2016, 'Sex hormone manipulation slows reaction time and increases labile mood in healthy women', Psychoneuroendocrinology, bind 68, s. 39-46. https://doi.org/10.1016/j.psyneuen.2016.02.023

APA

Stenbæk, D. S., Fisher, P. M., Budtz-Jørgensen, E., Pinborg, A., Hjordt, L. V., Jensen, P. S., Knudsen, G. M., & Frokjaer, V. G. (2016). Sex hormone manipulation slows reaction time and increases labile mood in healthy women. Psychoneuroendocrinology, 68, 39-46. https://doi.org/10.1016/j.psyneuen.2016.02.023

Vancouver

Stenbæk DS, Fisher PM, Budtz-Jørgensen E, Pinborg A, Hjordt LV, Jensen PS o.a. Sex hormone manipulation slows reaction time and increases labile mood in healthy women. Psychoneuroendocrinology. 2016 jun.;68:39-46. https://doi.org/10.1016/j.psyneuen.2016.02.023

Author

Stenbæk, D. S. ; Fisher, P M ; Budtz-Jørgensen, E. ; Pinborg, A. ; Hjordt, L. V. ; Jensen, P. S. ; Knudsen, G. M. ; Frokjaer, V. G. / Sex hormone manipulation slows reaction time and increases labile mood in healthy women. I: Psychoneuroendocrinology. 2016 ; Bind 68. s. 39-46.

Bibtex

@article{8bd4b5d2175447389ed12eb4341995e2,

title = "Sex hormone manipulation slows reaction time and increases labile mood in healthy women",

abstract = "BACKGROUND: Women show increased risk of depressive symptoms in life phases where ovarian steroid hormone levels fluctuate or decline rapidly. The risk mechanisms may include changes in mental state and affective cognition possibly mediated by serotonergic neurotransmission.METHODS: In a randomized controlled double-blinded trial, 61 healthy women (mean age 24.3±4.9 years) were tested with measures of affective verbal memory, reaction time, mental distress, and serotonin transporter binding at baseline and at follow-up after receiving gonadotropin-releasing hormone agonist (GnRHa) or placebo intervention. Women also reported daily mood profiles during intervention. We tested direct effects of intervention and indirect effects through changes in serotonin transporter binding on verbal affective memory, simple reaction time and self-reported measures of mental distress, and further effects of GnRHa on daily mood.RESULTS: GnRHa induced an increase in simple reaction time (p=0.03) and more pronounced fluctuations in daily self-reported mood in a manner dependent on baseline mood (p=0.003). Verbal affective memory recall, overall self-perceived mental distress, and serotonin transporter binding were not affected.CONCLUSIONS: In healthy women transient sex-steroid hormone fluctuations decrease speed of information processing and further produce more labile mood only in women with elevated levels of mood disturbances at baseline.",

author = "Stenb{\ae}k, {D. S.} and Fisher, {P M} and E. Budtz-J{\o}rgensen and A. Pinborg and Hjordt, {L. V.} and Jensen, {P. S.} and Knudsen, {G. M.} and Frokjaer, {V. G.}",

year = "2016",

month = jun,

doi = "10.1016/j.psyneuen.2016.02.023",

language = "English",

volume = "68",

pages = "39--46",

journal = "Psychoneuroendocrinology",

issn = "0306-4530",

publisher = "Pergamon Press",

}

RIS

TY - JOUR

T1 - Sex hormone manipulation slows reaction time and increases labile mood in healthy women

AU - Stenbæk, D. S.

AU - Fisher, P M

AU - Budtz-Jørgensen, E.

AU - Pinborg, A.

AU - Hjordt, L. V.

AU - Jensen, P. S.

AU - Knudsen, G. M.

AU - Frokjaer, V. G.

PY - 2016/6

Y1 - 2016/6

N2 - BACKGROUND: Women show increased risk of depressive symptoms in life phases where ovarian steroid hormone levels fluctuate or decline rapidly. The risk mechanisms may include changes in mental state and affective cognition possibly mediated by serotonergic neurotransmission.METHODS: In a randomized controlled double-blinded trial, 61 healthy women (mean age 24.3±4.9 years) were tested with measures of affective verbal memory, reaction time, mental distress, and serotonin transporter binding at baseline and at follow-up after receiving gonadotropin-releasing hormone agonist (GnRHa) or placebo intervention. Women also reported daily mood profiles during intervention. We tested direct effects of intervention and indirect effects through changes in serotonin transporter binding on verbal affective memory, simple reaction time and self-reported measures of mental distress, and further effects of GnRHa on daily mood.RESULTS: GnRHa induced an increase in simple reaction time (p=0.03) and more pronounced fluctuations in daily self-reported mood in a manner dependent on baseline mood (p=0.003). Verbal affective memory recall, overall self-perceived mental distress, and serotonin transporter binding were not affected.CONCLUSIONS: In healthy women transient sex-steroid hormone fluctuations decrease speed of information processing and further produce more labile mood only in women with elevated levels of mood disturbances at baseline.

AB - BACKGROUND: Women show increased risk of depressive symptoms in life phases where ovarian steroid hormone levels fluctuate or decline rapidly. The risk mechanisms may include changes in mental state and affective cognition possibly mediated by serotonergic neurotransmission.METHODS: In a randomized controlled double-blinded trial, 61 healthy women (mean age 24.3±4.9 years) were tested with measures of affective verbal memory, reaction time, mental distress, and serotonin transporter binding at baseline and at follow-up after receiving gonadotropin-releasing hormone agonist (GnRHa) or placebo intervention. Women also reported daily mood profiles during intervention. We tested direct effects of intervention and indirect effects through changes in serotonin transporter binding on verbal affective memory, simple reaction time and self-reported measures of mental distress, and further effects of GnRHa on daily mood.RESULTS: GnRHa induced an increase in simple reaction time (p=0.03) and more pronounced fluctuations in daily self-reported mood in a manner dependent on baseline mood (p=0.003). Verbal affective memory recall, overall self-perceived mental distress, and serotonin transporter binding were not affected.CONCLUSIONS: In healthy women transient sex-steroid hormone fluctuations decrease speed of information processing and further produce more labile mood only in women with elevated levels of mood disturbances at baseline.

U2 - 10.1016/j.psyneuen.2016.02.023

DO - 10.1016/j.psyneuen.2016.02.023

M3 - Journal article

C2 - 26943343

VL - 68

SP - 39

EP - 46

JO - Psychoneuroendocrinology

JF - Psychoneuroendocrinology

SN - 0306-4530

ER -

ID: 161882581