Schistosomamansoni Infection in Preschool-Aged Children: Development of Immunoglobulin E and Immunoglobulin G4 Responses to Parasite Allergen-Like Proteins

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Standard

Schistosomamansoni Infection in Preschool-Aged Children : Development of Immunoglobulin E and Immunoglobulin G4 Responses to Parasite Allergen-Like Proteins. / Pinot de Moira, Angela; Sousa-Figueiredo, Jose C; Jones, Frances M; Fitzsimmons, Colin M; Betson, Martha; Kabatereine, Narcis B; Stothard, J Russell; Dunne, David W.

I: The Journal of Infectious Diseases, Bind 207, Nr. 2, 2013, s. 362-366.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Pinot de Moira, A, Sousa-Figueiredo, JC, Jones, FM, Fitzsimmons, CM, Betson, M, Kabatereine, NB, Stothard, JR & Dunne, DW 2013, 'Schistosomamansoni Infection in Preschool-Aged Children: Development of Immunoglobulin E and Immunoglobulin G4 Responses to Parasite Allergen-Like Proteins', The Journal of Infectious Diseases, bind 207, nr. 2, s. 362-366. https://doi.org/10.1093/infdis/jis676

APA

Pinot de Moira, A., Sousa-Figueiredo, J. C., Jones, F. M., Fitzsimmons, C. M., Betson, M., Kabatereine, N. B., Stothard, J. R., & Dunne, D. W. (2013). Schistosomamansoni Infection in Preschool-Aged Children: Development of Immunoglobulin E and Immunoglobulin G4 Responses to Parasite Allergen-Like Proteins. The Journal of Infectious Diseases, 207(2), 362-366. https://doi.org/10.1093/infdis/jis676

Vancouver

Pinot de Moira A, Sousa-Figueiredo JC, Jones FM, Fitzsimmons CM, Betson M, Kabatereine NB o.a. Schistosomamansoni Infection in Preschool-Aged Children: Development of Immunoglobulin E and Immunoglobulin G4 Responses to Parasite Allergen-Like Proteins. The Journal of Infectious Diseases. 2013;207(2):362-366. https://doi.org/10.1093/infdis/jis676

Author

Pinot de Moira, Angela ; Sousa-Figueiredo, Jose C ; Jones, Frances M ; Fitzsimmons, Colin M ; Betson, Martha ; Kabatereine, Narcis B ; Stothard, J Russell ; Dunne, David W. / Schistosomamansoni Infection in Preschool-Aged Children : Development of Immunoglobulin E and Immunoglobulin G4 Responses to Parasite Allergen-Like Proteins. I: The Journal of Infectious Diseases. 2013 ; Bind 207, Nr. 2. s. 362-366.

Bibtex

@article{5a1d192415234194a5af8b1fb48c1aa1,
title = "Schistosomamansoni Infection in Preschool-Aged Children: Development of Immunoglobulin E and Immunoglobulin G4 Responses to Parasite Allergen-Like Proteins",
abstract = "Specific immunoglobulin E (IgE) responses are upregulated during chronic schistosome infection and during allergy. These responses are tightly regulated during schistosomiasis. We have previously shown that IgE regulation depends on the extent and length of exposure to individual parasite allergen-like proteins. Here we compare the development of IgE and immunoglobulin G4 (IgG(4)) responses to the differentially expressed allergen-like proteins SmTAL1 and SmTAL2 among preschool-aged children from 2 villages with different levels of Schistosoma mansoni transmission. We found a lack of SmTAL1 responsiveness among all children, but evidence for IgG(4)-dependent IgE-SmTAL2 desensitization in both villages, occurring earlier among children from the village where the level of transmission was greater. Findings provide insights into the development and regulation of allergic-type immune responses.",
keywords = "Adult, Allergens/immunology, Animals, Child, Preschool, Female, Helminth Proteins/immunology, Humans, Immunoglobulin E/blood, Immunoglobulin G/blood, Infant, Schistosoma mansoni/immunology, Schistosomiasis mansoni/immunology, Uganda",
author = "{Pinot de Moira}, Angela and Sousa-Figueiredo, {Jose C} and Jones, {Frances M} and Fitzsimmons, {Colin M} and Martha Betson and Kabatereine, {Narcis B} and Stothard, {J Russell} and Dunne, {David W}",
year = "2013",
doi = "10.1093/infdis/jis676",
language = "English",
volume = "207",
pages = "362--366",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "2",

}

RIS

TY - JOUR

T1 - Schistosomamansoni Infection in Preschool-Aged Children

T2 - Development of Immunoglobulin E and Immunoglobulin G4 Responses to Parasite Allergen-Like Proteins

AU - Pinot de Moira, Angela

AU - Sousa-Figueiredo, Jose C

AU - Jones, Frances M

AU - Fitzsimmons, Colin M

AU - Betson, Martha

AU - Kabatereine, Narcis B

AU - Stothard, J Russell

AU - Dunne, David W

PY - 2013

Y1 - 2013

N2 - Specific immunoglobulin E (IgE) responses are upregulated during chronic schistosome infection and during allergy. These responses are tightly regulated during schistosomiasis. We have previously shown that IgE regulation depends on the extent and length of exposure to individual parasite allergen-like proteins. Here we compare the development of IgE and immunoglobulin G4 (IgG(4)) responses to the differentially expressed allergen-like proteins SmTAL1 and SmTAL2 among preschool-aged children from 2 villages with different levels of Schistosoma mansoni transmission. We found a lack of SmTAL1 responsiveness among all children, but evidence for IgG(4)-dependent IgE-SmTAL2 desensitization in both villages, occurring earlier among children from the village where the level of transmission was greater. Findings provide insights into the development and regulation of allergic-type immune responses.

AB - Specific immunoglobulin E (IgE) responses are upregulated during chronic schistosome infection and during allergy. These responses are tightly regulated during schistosomiasis. We have previously shown that IgE regulation depends on the extent and length of exposure to individual parasite allergen-like proteins. Here we compare the development of IgE and immunoglobulin G4 (IgG(4)) responses to the differentially expressed allergen-like proteins SmTAL1 and SmTAL2 among preschool-aged children from 2 villages with different levels of Schistosoma mansoni transmission. We found a lack of SmTAL1 responsiveness among all children, but evidence for IgG(4)-dependent IgE-SmTAL2 desensitization in both villages, occurring earlier among children from the village where the level of transmission was greater. Findings provide insights into the development and regulation of allergic-type immune responses.

KW - Adult

KW - Allergens/immunology

KW - Animals

KW - Child, Preschool

KW - Female

KW - Helminth Proteins/immunology

KW - Humans

KW - Immunoglobulin E/blood

KW - Immunoglobulin G/blood

KW - Infant

KW - Schistosoma mansoni/immunology

KW - Schistosomiasis mansoni/immunology

KW - Uganda

U2 - 10.1093/infdis/jis676

DO - 10.1093/infdis/jis676

M3 - Journal article

C2 - 23125445

VL - 207

SP - 362

EP - 366

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 2

ER -

ID: 314968471