S100B and brain derived neurotrophic factor in monozygotic twins with, at risk of and without affective disorders
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S100B and brain derived neurotrophic factor in monozygotic twins with, at risk of and without affective disorders. / Ottesen, Ninja Meinhard; Meluken, Iselin; Frikke-Schmidt, Ruth; Plomgaard, Peter; Scheike, Thomas; Kessing, Lars Vedel; Miskowiak, Kamilla; Vinberg, Maj.
I: Journal of Affective Disorders, Bind 274, 2020, s. 726-732.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - S100B and brain derived neurotrophic factor in monozygotic twins with, at risk of and without affective disorders
AU - Ottesen, Ninja Meinhard
AU - Meluken, Iselin
AU - Frikke-Schmidt, Ruth
AU - Plomgaard, Peter
AU - Scheike, Thomas
AU - Kessing, Lars Vedel
AU - Miskowiak, Kamilla
AU - Vinberg, Maj
PY - 2020
Y1 - 2020
N2 - Background: The calcium binding protein S100B and brain derived neurotrophic factor (BDNF) are both bio-markers implicated in neuronal processes in the central nervous system and seem to be associated with affective disorders. Here we investigated both markers in a sample of monozygotic (MZ) twins with, at risk of and without affective disorders, aiming to evaluate whether these markers have a role as causal factors-or trait markers for affective disorders. Method: We measured serum S100B and plasma BDNF levels in 204 monozygotic twins (MZ) with unipolar or bipolar disorder in remission or partial remission (affected), their unaffected co-twins (high-risk) and twins with no personal or family history of affective disorder (low-risk). Results: No significant group differences in S100B and BDNF levels were found between the three groups. Exploratory analysis revealed that higher S100B levels were correlated with lower cognitive performance. Limitations: The cross-sectional design cannot elucidate the two neuronal biomarkers role as causal factors. We would have preferred a higher sample size in the high-and low-risk groups. Conclusion: The present result did not support a role for S100B and BDNF as neither causal factors nor trait markers for affective disorders. Elevated S100B levels may associate with impaired cognition, but further studies are warranted.
AB - Background: The calcium binding protein S100B and brain derived neurotrophic factor (BDNF) are both bio-markers implicated in neuronal processes in the central nervous system and seem to be associated with affective disorders. Here we investigated both markers in a sample of monozygotic (MZ) twins with, at risk of and without affective disorders, aiming to evaluate whether these markers have a role as causal factors-or trait markers for affective disorders. Method: We measured serum S100B and plasma BDNF levels in 204 monozygotic twins (MZ) with unipolar or bipolar disorder in remission or partial remission (affected), their unaffected co-twins (high-risk) and twins with no personal or family history of affective disorder (low-risk). Results: No significant group differences in S100B and BDNF levels were found between the three groups. Exploratory analysis revealed that higher S100B levels were correlated with lower cognitive performance. Limitations: The cross-sectional design cannot elucidate the two neuronal biomarkers role as causal factors. We would have preferred a higher sample size in the high-and low-risk groups. Conclusion: The present result did not support a role for S100B and BDNF as neither causal factors nor trait markers for affective disorders. Elevated S100B levels may associate with impaired cognition, but further studies are warranted.
KW - Affective disorder
KW - Monozygotic twins
KW - High-risk-study
KW - S100B
KW - BDNF
KW - BIPOLAR DISORDER
KW - COGNITIVE DYSFUNCTION
KW - MOOD DISORDERS
KW - GLIAL PATHOLOGY
KW - DEPRESSION
KW - PERFORMANCE
KW - IMPAIRMENT
KW - VALIDATION
KW - SINGLETONS
U2 - 10.1016/j.jad.2020.05.015
DO - 10.1016/j.jad.2020.05.015
M3 - Journal article
C2 - 32664008
VL - 274
SP - 726
EP - 732
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
SN - 0165-0327
ER -
ID: 244999023