Risk of diabetes among related and unrelated family members

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Risk of diabetes among related and unrelated family members. / Aasbjerg, Kristian; Nørgaard, Caroline Holm; Vestergaard, Nanna; Søgaard, Peter; Køber, Lars; Weeke, Peter; Gislason, Gunnar; Torp-Pedersen, Christian.

I: Diabetes Research and Clinical Practice, Bind 160, 107997, 02.2020.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Aasbjerg, K, Nørgaard, CH, Vestergaard, N, Søgaard, P, Køber, L, Weeke, P, Gislason, G & Torp-Pedersen, C 2020, 'Risk of diabetes among related and unrelated family members', Diabetes Research and Clinical Practice, bind 160, 107997. https://doi.org/10.1016/j.diabres.2019.107997

APA

Aasbjerg, K., Nørgaard, C. H., Vestergaard, N., Søgaard, P., Køber, L., Weeke, P., Gislason, G., & Torp-Pedersen, C. (2020). Risk of diabetes among related and unrelated family members. Diabetes Research and Clinical Practice, 160, [107997]. https://doi.org/10.1016/j.diabres.2019.107997

Vancouver

Aasbjerg K, Nørgaard CH, Vestergaard N, Søgaard P, Køber L, Weeke P o.a. Risk of diabetes among related and unrelated family members. Diabetes Research and Clinical Practice. 2020 feb.;160. 107997. https://doi.org/10.1016/j.diabres.2019.107997

Author

Aasbjerg, Kristian ; Nørgaard, Caroline Holm ; Vestergaard, Nanna ; Søgaard, Peter ; Køber, Lars ; Weeke, Peter ; Gislason, Gunnar ; Torp-Pedersen, Christian. / Risk of diabetes among related and unrelated family members. I: Diabetes Research and Clinical Practice. 2020 ; Bind 160.

Bibtex

@article{9af8c66bf4c64f73b14a6c0c2cf0616a,

title = "Risk of diabetes among related and unrelated family members",

abstract = "AIMS: The aim was to explore familial aggregation of diabetes in genetically related and unrelated individuals.METHODS: We included citizens from Danish nationwide registries between 1995 and 2018 and calculated rate ratios (RR) of diabetes based on family relation using Poisson regression.RESULTS: Of 7.3 million individuals eligible for inclusion, we identified 343,237 (4.7%) with diabetes. The RR of diabetes was 2.02 (95% CI: 1.99-2.05; p < 0.0001) if any relative had diabetes, 1.79 (95% CI: 1.76-1.83) if a father had diabetes, and 2.06 (95% CI: 2.02-2.10) if a mother had diabetes. If both parents had diabetes, the RR was 3.40 (95% CI: 3.24-3.56). Among full siblings, the RR for developing diabetes was 2.77 (95% CI: 2.71-2.84) and 5.76 (95% CI: 5.00-6.63) for twins. For second-degree relatives, half siblings with a common mother had a RR of 2.35 (95% CI: 2.15-2.56), and with a common father 1.99 (95% CI: 1.81-2.17). Furthermore, the RR was 1.60 (95% CI: 1.56-1.64) if a wife had diabetes, and 1.41 (95% CI: 1.38-1.44) if a husband had diabetes. A subgroup analysis of individuals receiving insulin only treatment (N = 23,054) demonstrated a similar risk pattern, although with slightly higher risk estimates.CONCLUSIONS/INTERPRETATION: Family aggregation of diabetes is associated with genetic disposition with maternal status being the predominant factor. Furthermore, we observed increased risk of diabetes in second-degree relatives, and between unrelated spouses, indicating that environmental factors influence diabetes risk substantially.",

keywords = "Adult, Aged, Diabetes Mellitus/etiology, Environmental Health/methods, Family, Female, Humans, Male, Middle Aged, Risk Factors",

author = "Kristian Aasbjerg and N{\o}rgaard, {Caroline Holm} and Nanna Vestergaard and Peter S{\o}gaard and Lars K{\o}ber and Peter Weeke and Gunnar Gislason and Christian Torp-Pedersen",

year = "2020",

month = feb,

doi = "10.1016/j.diabres.2019.107997",

language = "English",

volume = "160",

journal = "Diabetes Research and Clinical Practice",

issn = "0168-8227",

publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Risk of diabetes among related and unrelated family members

AU - Aasbjerg, Kristian

AU - Nørgaard, Caroline Holm

AU - Vestergaard, Nanna

AU - Søgaard, Peter

AU - Køber, Lars

AU - Weeke, Peter

AU - Gislason, Gunnar

AU - Torp-Pedersen, Christian

PY - 2020/2

Y1 - 2020/2

N2 - AIMS: The aim was to explore familial aggregation of diabetes in genetically related and unrelated individuals.METHODS: We included citizens from Danish nationwide registries between 1995 and 2018 and calculated rate ratios (RR) of diabetes based on family relation using Poisson regression.RESULTS: Of 7.3 million individuals eligible for inclusion, we identified 343,237 (4.7%) with diabetes. The RR of diabetes was 2.02 (95% CI: 1.99-2.05; p < 0.0001) if any relative had diabetes, 1.79 (95% CI: 1.76-1.83) if a father had diabetes, and 2.06 (95% CI: 2.02-2.10) if a mother had diabetes. If both parents had diabetes, the RR was 3.40 (95% CI: 3.24-3.56). Among full siblings, the RR for developing diabetes was 2.77 (95% CI: 2.71-2.84) and 5.76 (95% CI: 5.00-6.63) for twins. For second-degree relatives, half siblings with a common mother had a RR of 2.35 (95% CI: 2.15-2.56), and with a common father 1.99 (95% CI: 1.81-2.17). Furthermore, the RR was 1.60 (95% CI: 1.56-1.64) if a wife had diabetes, and 1.41 (95% CI: 1.38-1.44) if a husband had diabetes. A subgroup analysis of individuals receiving insulin only treatment (N = 23,054) demonstrated a similar risk pattern, although with slightly higher risk estimates.CONCLUSIONS/INTERPRETATION: Family aggregation of diabetes is associated with genetic disposition with maternal status being the predominant factor. Furthermore, we observed increased risk of diabetes in second-degree relatives, and between unrelated spouses, indicating that environmental factors influence diabetes risk substantially.

AB - AIMS: The aim was to explore familial aggregation of diabetes in genetically related and unrelated individuals.METHODS: We included citizens from Danish nationwide registries between 1995 and 2018 and calculated rate ratios (RR) of diabetes based on family relation using Poisson regression.RESULTS: Of 7.3 million individuals eligible for inclusion, we identified 343,237 (4.7%) with diabetes. The RR of diabetes was 2.02 (95% CI: 1.99-2.05; p < 0.0001) if any relative had diabetes, 1.79 (95% CI: 1.76-1.83) if a father had diabetes, and 2.06 (95% CI: 2.02-2.10) if a mother had diabetes. If both parents had diabetes, the RR was 3.40 (95% CI: 3.24-3.56). Among full siblings, the RR for developing diabetes was 2.77 (95% CI: 2.71-2.84) and 5.76 (95% CI: 5.00-6.63) for twins. For second-degree relatives, half siblings with a common mother had a RR of 2.35 (95% CI: 2.15-2.56), and with a common father 1.99 (95% CI: 1.81-2.17). Furthermore, the RR was 1.60 (95% CI: 1.56-1.64) if a wife had diabetes, and 1.41 (95% CI: 1.38-1.44) if a husband had diabetes. A subgroup analysis of individuals receiving insulin only treatment (N = 23,054) demonstrated a similar risk pattern, although with slightly higher risk estimates.CONCLUSIONS/INTERPRETATION: Family aggregation of diabetes is associated with genetic disposition with maternal status being the predominant factor. Furthermore, we observed increased risk of diabetes in second-degree relatives, and between unrelated spouses, indicating that environmental factors influence diabetes risk substantially.

KW - Adult

KW - Aged

KW - Diabetes Mellitus/etiology

KW - Environmental Health/methods

KW - Family

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Risk Factors

U2 - 10.1016/j.diabres.2019.107997

DO - 10.1016/j.diabres.2019.107997

M3 - Journal article

C2 - 31901471

VL - 160

JO - Diabetes Research and Clinical Practice

JF - Diabetes Research and Clinical Practice

SN - 0168-8227

M1 - 107997

ER -

ID: 252298349