Risk for multiple sclerosis in dizygotic and monozygotic twins

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Risk for multiple sclerosis in dizygotic and monozygotic twins. / Hansen, Thomas; Skytthe, Axel; Stenager, Egon; Petersen, Hans Christian; Kyvik, Kirsten Ohm; Brønnum-Hansen, Henrik.

I: Multiple Sclerosis, Bind 11, Nr. 5, 2005, s. 500-3.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Hansen, T, Skytthe, A, Stenager, E, Petersen, HC, Kyvik, KO & Brønnum-Hansen, H 2005, 'Risk for multiple sclerosis in dizygotic and monozygotic twins', Multiple Sclerosis, bind 11, nr. 5, s. 500-3.

APA

Hansen, T., Skytthe, A., Stenager, E., Petersen, H. C., Kyvik, K. O., & Brønnum-Hansen, H. (2005). Risk for multiple sclerosis in dizygotic and monozygotic twins. Multiple Sclerosis, 11(5), 500-3.

Vancouver

Hansen T, Skytthe A, Stenager E, Petersen HC, Kyvik KO, Brønnum-Hansen H. Risk for multiple sclerosis in dizygotic and monozygotic twins. Multiple Sclerosis. 2005;11(5):500-3.

Author

Hansen, Thomas ; Skytthe, Axel ; Stenager, Egon ; Petersen, Hans Christian ; Kyvik, Kirsten Ohm ; Brønnum-Hansen, Henrik. / Risk for multiple sclerosis in dizygotic and monozygotic twins. I: Multiple Sclerosis. 2005 ; Bind 11, Nr. 5. s. 500-3.

Bibtex

@article{97e1aa1a73fa47dbad3dc02ac1e87c23,
title = "Risk for multiple sclerosis in dizygotic and monozygotic twins",
abstract = "We investigated the risks of twins for multiple sclerosis (MS). Our data are linked registers of all Danish twins and of all Danes born between 1920 and 1970 in whom MS was diagnosed before 1997. We compared differences in the risks for MS by Cox regression and standardized incidence ratios. Our analyses suggest that dizygotic twins have an approximately 60% lower risk for MS than monozygotic twins and a 20% lower risk than singletons. Monozygotic twins appear to have a somewhat higher risk for MS than singletons albeit not statistically significant. We offer no biological explanation for our findings, but suggest that either sharing fetal life with a genotypically different individual is beneficial for the immune system or that there is a linkage between the genes that influence dizygotic twinning and other genes that protect against MS.",
keywords = "Adult, Aged, Aged, 80 and over, Denmark, Female, Humans, Incidence, Male, Middle Aged, Multiple Sclerosis, Registries, Risk Factors, Twins, Dizygotic, Twins, Monozygotic",
author = "Thomas Hansen and Axel Skytthe and Egon Stenager and Petersen, {Hans Christian} and Kyvik, {Kirsten Ohm} and Henrik Br{\o}nnum-Hansen",
year = "2005",
language = "English",
volume = "11",
pages = "500--3",
journal = "Multiple Sclerosis Journal",
issn = "1352-4585",
publisher = "SAGE Publications",
number = "5",

}

RIS

TY - JOUR

T1 - Risk for multiple sclerosis in dizygotic and monozygotic twins

AU - Hansen, Thomas

AU - Skytthe, Axel

AU - Stenager, Egon

AU - Petersen, Hans Christian

AU - Kyvik, Kirsten Ohm

AU - Brønnum-Hansen, Henrik

PY - 2005

Y1 - 2005

N2 - We investigated the risks of twins for multiple sclerosis (MS). Our data are linked registers of all Danish twins and of all Danes born between 1920 and 1970 in whom MS was diagnosed before 1997. We compared differences in the risks for MS by Cox regression and standardized incidence ratios. Our analyses suggest that dizygotic twins have an approximately 60% lower risk for MS than monozygotic twins and a 20% lower risk than singletons. Monozygotic twins appear to have a somewhat higher risk for MS than singletons albeit not statistically significant. We offer no biological explanation for our findings, but suggest that either sharing fetal life with a genotypically different individual is beneficial for the immune system or that there is a linkage between the genes that influence dizygotic twinning and other genes that protect against MS.

AB - We investigated the risks of twins for multiple sclerosis (MS). Our data are linked registers of all Danish twins and of all Danes born between 1920 and 1970 in whom MS was diagnosed before 1997. We compared differences in the risks for MS by Cox regression and standardized incidence ratios. Our analyses suggest that dizygotic twins have an approximately 60% lower risk for MS than monozygotic twins and a 20% lower risk than singletons. Monozygotic twins appear to have a somewhat higher risk for MS than singletons albeit not statistically significant. We offer no biological explanation for our findings, but suggest that either sharing fetal life with a genotypically different individual is beneficial for the immune system or that there is a linkage between the genes that influence dizygotic twinning and other genes that protect against MS.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Denmark

KW - Female

KW - Humans

KW - Incidence

KW - Male

KW - Middle Aged

KW - Multiple Sclerosis

KW - Registries

KW - Risk Factors

KW - Twins, Dizygotic

KW - Twins, Monozygotic

M3 - Journal article

C2 - 16193884

VL - 11

SP - 500

EP - 503

JO - Multiple Sclerosis Journal

JF - Multiple Sclerosis Journal

SN - 1352-4585

IS - 5

ER -

ID: 44172140