Residential pyrethroid insecticide use, urinary 3-phenoxybenzoic acid levels, and attention-deficit/hyperactivity disorder-like symptoms in preschool-age children: The Environment and Development of Children study

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Residential pyrethroid insecticide use, urinary 3-phenoxybenzoic acid levels, and attention-deficit/hyperactivity disorder-like symptoms in preschool-age children : The Environment and Development of Children study. / Lee, Woo-Seok; Lim, Youn-Hee; Kim, Bung-Nyun; Shin, Choong Ho; Lee, Young Ah; Kim, Johanna Inhyang; Hong, Yun-Chul; Kim, Kyoung-Nam.

I: Environmental Research, Bind 188, 109739, 28.05.2020.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Lee, W-S, Lim, Y-H, Kim, B-N, Shin, CH, Lee, YA, Kim, JI, Hong, Y-C & Kim, K-N 2020, 'Residential pyrethroid insecticide use, urinary 3-phenoxybenzoic acid levels, and attention-deficit/hyperactivity disorder-like symptoms in preschool-age children: The Environment and Development of Children study', Environmental Research, bind 188, 109739. https://doi.org/10.1016/j.envres.2020.109739

APA

Lee, W-S., Lim, Y-H., Kim, B-N., Shin, C. H., Lee, Y. A., Kim, J. I., ... Kim, K-N. (2020). Residential pyrethroid insecticide use, urinary 3-phenoxybenzoic acid levels, and attention-deficit/hyperactivity disorder-like symptoms in preschool-age children: The Environment and Development of Children study. Environmental Research, 188, [109739]. https://doi.org/10.1016/j.envres.2020.109739

Vancouver

Lee W-S, Lim Y-H, Kim B-N, Shin CH, Lee YA, Kim JI o.a. Residential pyrethroid insecticide use, urinary 3-phenoxybenzoic acid levels, and attention-deficit/hyperactivity disorder-like symptoms in preschool-age children: The Environment and Development of Children study. Environmental Research. 2020 maj 28;188. 109739. https://doi.org/10.1016/j.envres.2020.109739

Author

Lee, Woo-Seok ; Lim, Youn-Hee ; Kim, Bung-Nyun ; Shin, Choong Ho ; Lee, Young Ah ; Kim, Johanna Inhyang ; Hong, Yun-Chul ; Kim, Kyoung-Nam. / Residential pyrethroid insecticide use, urinary 3-phenoxybenzoic acid levels, and attention-deficit/hyperactivity disorder-like symptoms in preschool-age children : The Environment and Development of Children study. I: Environmental Research. 2020 ; Bind 188.

Bibtex

@article{7a0579f80f114fc5b7a782f4d1dcc729,
title = "Residential pyrethroid insecticide use, urinary 3-phenoxybenzoic acid levels, and attention-deficit/hyperactivity disorder-like symptoms in preschool-age children: The Environment and Development of Children study",
abstract = "Previous animal studies have reported that pyrethroids can cause dopamine system abnormalities and attention-deficit/hyperactivity disorder (ADHD) phenotypes. However, epidemiological studies investigating the associations between pyrethroid exposure and ADHD are limited. We aimed to investigate the association between pyrethroid exposure and ADHD-like symptoms among preschool-age children. We used data from 385 children at 4 years of age participating in the Environment and Development of Children (EDC) study. We evaluated pyrethroid exposure through questionnaires and urinary 3-phenoxybenzoic acid (3-PBA) concentrations. We assessed ADHD-like symptoms using the Korean ADHD rating scale (K-ARS). We conducted negative binomial regressions to evaluate the associations between pyrethroid exposure and ADHD-like symptoms. Residential use of insecticide adhesive (β = 0.42, 95{\%} CI: 0.11, 0.74) and insecticide spray (β = 0.33, 95{\%} CI: 0.08, 0.59) was associated with an increase in log-transformed creatinine-adjusted urinary 3-PBA concentrations. Residential insecticide adhesive use was associated with a 51.6{\%} increase in K-ARS scores (95{\%} confidence interval [CI]: 6.3, 116.1) among boys, when compared with non-users. When compared with creatinine-adjusted 3-PBA levels <0.50 μg/g creatinine, creatinine-adjusted 3-PBA levels ≥3.80 μg/g creatinine were associated with a 58{\%} increase in K-ARS scores (95{\%} CI: 0.1, 150.5) among boys. We found associations of residential pyrethroid insecticide use and urinary 3-PBA concentrations with K-ARS scores among preschool-age boys. Since the present study explored cross-sectional associations in preschool-age children, the possibility of reverse causality cannot be dismissed. Further studies implementing a cohort study design are warranted.",
author = "Woo-Seok Lee and Youn-Hee Lim and Bung-Nyun Kim and Shin, {Choong Ho} and Lee, {Young Ah} and Kim, {Johanna Inhyang} and Yun-Chul Hong and Kyoung-Nam Kim",
note = "Copyright {\circledC} 2020 Elsevier Inc. All rights reserved.",
year = "2020",
month = "5",
day = "28",
doi = "10.1016/j.envres.2020.109739",
language = "English",
volume = "188",
journal = "Environmental Research",
issn = "0013-9351",
publisher = "Academic Press",

}

RIS

TY - JOUR

T1 - Residential pyrethroid insecticide use, urinary 3-phenoxybenzoic acid levels, and attention-deficit/hyperactivity disorder-like symptoms in preschool-age children

T2 - The Environment and Development of Children study

AU - Lee, Woo-Seok

AU - Lim, Youn-Hee

AU - Kim, Bung-Nyun

AU - Shin, Choong Ho

AU - Lee, Young Ah

AU - Kim, Johanna Inhyang

AU - Hong, Yun-Chul

AU - Kim, Kyoung-Nam

N1 - Copyright © 2020 Elsevier Inc. All rights reserved.

PY - 2020/5/28

Y1 - 2020/5/28

N2 - Previous animal studies have reported that pyrethroids can cause dopamine system abnormalities and attention-deficit/hyperactivity disorder (ADHD) phenotypes. However, epidemiological studies investigating the associations between pyrethroid exposure and ADHD are limited. We aimed to investigate the association between pyrethroid exposure and ADHD-like symptoms among preschool-age children. We used data from 385 children at 4 years of age participating in the Environment and Development of Children (EDC) study. We evaluated pyrethroid exposure through questionnaires and urinary 3-phenoxybenzoic acid (3-PBA) concentrations. We assessed ADHD-like symptoms using the Korean ADHD rating scale (K-ARS). We conducted negative binomial regressions to evaluate the associations between pyrethroid exposure and ADHD-like symptoms. Residential use of insecticide adhesive (β = 0.42, 95% CI: 0.11, 0.74) and insecticide spray (β = 0.33, 95% CI: 0.08, 0.59) was associated with an increase in log-transformed creatinine-adjusted urinary 3-PBA concentrations. Residential insecticide adhesive use was associated with a 51.6% increase in K-ARS scores (95% confidence interval [CI]: 6.3, 116.1) among boys, when compared with non-users. When compared with creatinine-adjusted 3-PBA levels <0.50 μg/g creatinine, creatinine-adjusted 3-PBA levels ≥3.80 μg/g creatinine were associated with a 58% increase in K-ARS scores (95% CI: 0.1, 150.5) among boys. We found associations of residential pyrethroid insecticide use and urinary 3-PBA concentrations with K-ARS scores among preschool-age boys. Since the present study explored cross-sectional associations in preschool-age children, the possibility of reverse causality cannot be dismissed. Further studies implementing a cohort study design are warranted.

AB - Previous animal studies have reported that pyrethroids can cause dopamine system abnormalities and attention-deficit/hyperactivity disorder (ADHD) phenotypes. However, epidemiological studies investigating the associations between pyrethroid exposure and ADHD are limited. We aimed to investigate the association between pyrethroid exposure and ADHD-like symptoms among preschool-age children. We used data from 385 children at 4 years of age participating in the Environment and Development of Children (EDC) study. We evaluated pyrethroid exposure through questionnaires and urinary 3-phenoxybenzoic acid (3-PBA) concentrations. We assessed ADHD-like symptoms using the Korean ADHD rating scale (K-ARS). We conducted negative binomial regressions to evaluate the associations between pyrethroid exposure and ADHD-like symptoms. Residential use of insecticide adhesive (β = 0.42, 95% CI: 0.11, 0.74) and insecticide spray (β = 0.33, 95% CI: 0.08, 0.59) was associated with an increase in log-transformed creatinine-adjusted urinary 3-PBA concentrations. Residential insecticide adhesive use was associated with a 51.6% increase in K-ARS scores (95% confidence interval [CI]: 6.3, 116.1) among boys, when compared with non-users. When compared with creatinine-adjusted 3-PBA levels <0.50 μg/g creatinine, creatinine-adjusted 3-PBA levels ≥3.80 μg/g creatinine were associated with a 58% increase in K-ARS scores (95% CI: 0.1, 150.5) among boys. We found associations of residential pyrethroid insecticide use and urinary 3-PBA concentrations with K-ARS scores among preschool-age boys. Since the present study explored cross-sectional associations in preschool-age children, the possibility of reverse causality cannot be dismissed. Further studies implementing a cohort study design are warranted.

U2 - 10.1016/j.envres.2020.109739

DO - 10.1016/j.envres.2020.109739

M3 - Journal article

C2 - 32504851

VL - 188

JO - Environmental Research

JF - Environmental Research

SN - 0013-9351

M1 - 109739

ER -

ID: 242708962