Reproductive hormone profile and pubertal development in 14-year-old boys prenatally exposed to polychlorinated biphenyls
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Reproductive hormone profile and pubertal development in 14-year-old boys prenatally exposed to polychlorinated biphenyls. / Grandjean, Philippe; Grønlund, Ciea; Kjær, Ina M; Jensen, Tina Kold; Sørensen, Nicolina; Andersson, Anna-Maria; Juul, Anders; Skakkebæk, Niels E; Budtz-Jørgensen, Esben; Weihe, Pal.
I: Reproductive Toxicology, Bind 34, Nr. 4, 2012, s. 498-503.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Reproductive hormone profile and pubertal development in 14-year-old boys prenatally exposed to polychlorinated biphenyls
AU - Grandjean, Philippe
AU - Grønlund, Ciea
AU - Kjær, Ina M
AU - Jensen, Tina Kold
AU - Sørensen, Nicolina
AU - Andersson, Anna-Maria
AU - Juul, Anders
AU - Skakkebæk, Niels E
AU - Budtz-Jørgensen, Esben
AU - Weihe, Pal
N1 - Copyright © 2012 Elsevier Inc. All rights reserved.
PY - 2012
Y1 - 2012
N2 - Because polychlorinated biphenyls (PCBs) are thought to cause endocrine disruption, we examined 438 adolescent boys from a birth cohort in the Faroe Islands, where PCB exposures are elevated. We measured PCBs and p,p'-dichlorodiphenyldichloroethylene (DDE) in cord blood and in serum from clinical examination at age 14. Higher prenatal PCB exposure was associated with lower serum concentrations of both luteinizing hormone (LH) and testosterone. In addition, sex hormone binding globulin (SHBG) was positively associated with both prenatal and concurrent PCB exposures. The PCB-SHBG association was robust to covariate adjustment. In a structural equation model, a doubling in prenatal PCB exposure was associated with a decrease in LH of 6% (p=0.03). Prenatal exposure to PCB and DDE showed weak, non-significant inverse associations with testicular size and Tanner stage. DDE was highly correlated with PCB and showed slightly weaker associations with the hormone profile. These findings suggest that delayed puberty with low serum-LH concentrations associated with developmental exposure to non dioxin-like PCBs may be due to a central hypothalamo-pituitary mechanism.
AB - Because polychlorinated biphenyls (PCBs) are thought to cause endocrine disruption, we examined 438 adolescent boys from a birth cohort in the Faroe Islands, where PCB exposures are elevated. We measured PCBs and p,p'-dichlorodiphenyldichloroethylene (DDE) in cord blood and in serum from clinical examination at age 14. Higher prenatal PCB exposure was associated with lower serum concentrations of both luteinizing hormone (LH) and testosterone. In addition, sex hormone binding globulin (SHBG) was positively associated with both prenatal and concurrent PCB exposures. The PCB-SHBG association was robust to covariate adjustment. In a structural equation model, a doubling in prenatal PCB exposure was associated with a decrease in LH of 6% (p=0.03). Prenatal exposure to PCB and DDE showed weak, non-significant inverse associations with testicular size and Tanner stage. DDE was highly correlated with PCB and showed slightly weaker associations with the hormone profile. These findings suggest that delayed puberty with low serum-LH concentrations associated with developmental exposure to non dioxin-like PCBs may be due to a central hypothalamo-pituitary mechanism.
U2 - 10.1016/j.reprotox.2012.07.005
DO - 10.1016/j.reprotox.2012.07.005
M3 - Journal article
C2 - 22841741
VL - 34
SP - 498
EP - 503
JO - Reproductive Toxicology
JF - Reproductive Toxicology
SN - 0890-6238
IS - 4
ER -
ID: 48487307