Reduction in mitochondrial DNA copy number in peripheral leukocytes after onset of Huntington's disease

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Standard

Reduction in mitochondrial DNA copy number in peripheral leukocytes after onset of Huntington's disease. / Petersen, Maria Hvidberg; Budtz-Jørgensen, Esben; Sørensen, Sven Asger; Nielsen, Jørgen Erik; Hjermind, Lena Elisabeth; Vinther-Jensen, Tua; Nielsen, Signe Marie Borch; Nørremølle, Anne.

I: Mitochondrion, Bind 17, 2014, s. 14-21.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Petersen, MH, Budtz-Jørgensen, E, Sørensen, SA, Nielsen, JE, Hjermind, LE, Vinther-Jensen, T, Nielsen, SMB & Nørremølle, A 2014, 'Reduction in mitochondrial DNA copy number in peripheral leukocytes after onset of Huntington's disease', Mitochondrion, bind 17, s. 14-21. https://doi.org/10.1016/j.mito.2014.05.001

APA

Petersen, M. H., Budtz-Jørgensen, E., Sørensen, S. A., Nielsen, J. E., Hjermind, L. E., Vinther-Jensen, T., Nielsen, S. M. B., & Nørremølle, A. (2014). Reduction in mitochondrial DNA copy number in peripheral leukocytes after onset of Huntington's disease. Mitochondrion, 17, 14-21. https://doi.org/10.1016/j.mito.2014.05.001

Vancouver

Petersen MH, Budtz-Jørgensen E, Sørensen SA, Nielsen JE, Hjermind LE, Vinther-Jensen T o.a. Reduction in mitochondrial DNA copy number in peripheral leukocytes after onset of Huntington's disease. Mitochondrion. 2014;17:14-21. https://doi.org/10.1016/j.mito.2014.05.001

Author

Petersen, Maria Hvidberg ; Budtz-Jørgensen, Esben ; Sørensen, Sven Asger ; Nielsen, Jørgen Erik ; Hjermind, Lena Elisabeth ; Vinther-Jensen, Tua ; Nielsen, Signe Marie Borch ; Nørremølle, Anne. / Reduction in mitochondrial DNA copy number in peripheral leukocytes after onset of Huntington's disease. I: Mitochondrion. 2014 ; Bind 17. s. 14-21.

Bibtex

@article{6331ec87583f4c5fa7057d63904a1cef,

title = "Reduction in mitochondrial DNA copy number in peripheral leukocytes after onset of Huntington's disease",

abstract = "Huntington's disease (HD) is an inherited neurodegenerative disorder characterised by movement disorder, cognitive symptoms and psychiatric symptoms with predominantly adult-onset. The mutant huntingtin protein leads to mitochondrial dysfunction in blood leukocytes. This discovery led to the investigation of the mitochondrial DNA (mtDNA) copy number relative to nuclear DNA (nDNA) in leukocytes from carriers of the HD mutation compared to healthy individuals. We found significantly reduced mtDNA/nDNA in HD mutation carriers compared to controls. A longitudinal study of archive DNA sample pairs from HD patients revealed a biphasic pattern of increasing mtDNA/nDNA before onset of motor symptoms and decreasing mtDNA/nDNA after.",

author = "Petersen, {Maria Hvidberg} and Esben Budtz-J{\o}rgensen and S{\o}rensen, {Sven Asger} and Nielsen, {J{\o}rgen Erik} and Hjermind, {Lena Elisabeth} and Tua Vinther-Jensen and Nielsen, {Signe Marie Borch} and Anne N{\o}rrem{\o}lle",

year = "2014",

doi = "10.1016/j.mito.2014.05.001",

language = "English",

volume = "17",

pages = "14--21",

journal = "Mitochondrion",

issn = "1567-7249",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Reduction in mitochondrial DNA copy number in peripheral leukocytes after onset of Huntington's disease

AU - Petersen, Maria Hvidberg

AU - Budtz-Jørgensen, Esben

AU - Sørensen, Sven Asger

AU - Nielsen, Jørgen Erik

AU - Hjermind, Lena Elisabeth

AU - Vinther-Jensen, Tua

AU - Nielsen, Signe Marie Borch

AU - Nørremølle, Anne

PY - 2014

Y1 - 2014

N2 - Huntington's disease (HD) is an inherited neurodegenerative disorder characterised by movement disorder, cognitive symptoms and psychiatric symptoms with predominantly adult-onset. The mutant huntingtin protein leads to mitochondrial dysfunction in blood leukocytes. This discovery led to the investigation of the mitochondrial DNA (mtDNA) copy number relative to nuclear DNA (nDNA) in leukocytes from carriers of the HD mutation compared to healthy individuals. We found significantly reduced mtDNA/nDNA in HD mutation carriers compared to controls. A longitudinal study of archive DNA sample pairs from HD patients revealed a biphasic pattern of increasing mtDNA/nDNA before onset of motor symptoms and decreasing mtDNA/nDNA after.

AB - Huntington's disease (HD) is an inherited neurodegenerative disorder characterised by movement disorder, cognitive symptoms and psychiatric symptoms with predominantly adult-onset. The mutant huntingtin protein leads to mitochondrial dysfunction in blood leukocytes. This discovery led to the investigation of the mitochondrial DNA (mtDNA) copy number relative to nuclear DNA (nDNA) in leukocytes from carriers of the HD mutation compared to healthy individuals. We found significantly reduced mtDNA/nDNA in HD mutation carriers compared to controls. A longitudinal study of archive DNA sample pairs from HD patients revealed a biphasic pattern of increasing mtDNA/nDNA before onset of motor symptoms and decreasing mtDNA/nDNA after.

U2 - 10.1016/j.mito.2014.05.001

DO - 10.1016/j.mito.2014.05.001

M3 - Journal article

C2 - 24836434

VL - 17

SP - 14

EP - 21

JO - Mitochondrion

JF - Mitochondrion

SN - 1567-7249

ER -

ID: 119359842