Pubertal timing, sex hormone levels, and associations between early life adversity and accelerated development amongst 11-year-old children of parents with schizophrenia or bipolar disorder and controls: The Danish high risk and Resilience study via 11
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Pubertal timing, sex hormone levels, and associations between early life adversity and accelerated development amongst 11-year-old children of parents with schizophrenia or bipolar disorder and controls : The Danish high risk and Resilience study via 11. / Krantz, Mette Falkenberg; Frederiksen, Hanne; Hjorthøj, Carsten; Søndergaard, Anne; Brandt, Julie Marie; Rohd, Sinnika Birkehøj; Veddum, Lotte; Steffensen, Nanna Lawaetz; Knudsen, Christina Bruun; Andreasen, Anna Krogh; Hemager, Nicoline; Burton, Birgitte Klee; Gregersen, Maja; Greve, Aja Neergaard; Ohland, Jessica; Bliksted, Vibeke; Mors, Ole; Thorup, Anne A.E.; Juul, Anders; Nordentoft, Merete.
I: Comprehensive Psychoneuroendocrinology, Bind 16, 100204, 2023.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Pubertal timing, sex hormone levels, and associations between early life adversity and accelerated development amongst 11-year-old children of parents with schizophrenia or bipolar disorder and controls
T2 - The Danish high risk and Resilience study via 11
AU - Krantz, Mette Falkenberg
AU - Frederiksen, Hanne
AU - Hjorthøj, Carsten
AU - Søndergaard, Anne
AU - Brandt, Julie Marie
AU - Rohd, Sinnika Birkehøj
AU - Veddum, Lotte
AU - Steffensen, Nanna Lawaetz
AU - Knudsen, Christina Bruun
AU - Andreasen, Anna Krogh
AU - Hemager, Nicoline
AU - Burton, Birgitte Klee
AU - Gregersen, Maja
AU - Greve, Aja Neergaard
AU - Ohland, Jessica
AU - Bliksted, Vibeke
AU - Mors, Ole
AU - Thorup, Anne A.E.
AU - Juul, Anders
AU - Nordentoft, Merete
N1 - Publisher Copyright: © 2023 The Author(s)
PY - 2023
Y1 - 2023
N2 - Background: Children of parents with severe mental illness have several known risk factors for altered pubertal timing. Pubertal timing is important for children's physical and emotional development. We aimed to examine pubertal timing and associations between pubertal timing, early life adversity and child problem behavior including psychiatric diagnoses among children of parents with schizophrenia or bipolar disorder and controls. Methods: Self-reported Tanner stage (mean age 11.9, range 10.87–12.67), sex hormone levels, home environment, placement out of home, and problem behavior including psychiatric diagnoses of children at familial high-risk (FHR) of schizophrenia (FHR-SZ), bipolar disorder (FHR-BP) and population-based controls (PBC) were assessed. Results: A total of 465 children participated in the study (Tanner assessment N = 417, sex hormones N = 293). Assessed with self-reported Tanner, no difference in pubertal timing was found between groups (p = 0.09). Hormone levels did not differ between groups except for inhibin B (mean (SD) = 55.86 (29.13) pg/mL for FHR-SZ girls vs 84.98 (47.98) pg/mL) for PBC girls (p < 0.001)) and for follicle stimulating hormone (FSH) (mean (SD) = 5.82 (1.45) U/L for FHR-BP girls vs 4.54 (1.68) U/L for PBC girls (p < 0.001)). FHR children who were placed out of home (17 children, 3.8% of participants) had higher Tanner stages than those living at home (p < 0.001). Timing was not associated with level of problem behavior or psychiatric diagnoses. Conclusions: FHR children did not differ from controls in pubertal timing. Early life adversity assessed as placement out of home may be associated with accelerated pubertal timing among children of parents with schizophrenia or bipolar disorder.
AB - Background: Children of parents with severe mental illness have several known risk factors for altered pubertal timing. Pubertal timing is important for children's physical and emotional development. We aimed to examine pubertal timing and associations between pubertal timing, early life adversity and child problem behavior including psychiatric diagnoses among children of parents with schizophrenia or bipolar disorder and controls. Methods: Self-reported Tanner stage (mean age 11.9, range 10.87–12.67), sex hormone levels, home environment, placement out of home, and problem behavior including psychiatric diagnoses of children at familial high-risk (FHR) of schizophrenia (FHR-SZ), bipolar disorder (FHR-BP) and population-based controls (PBC) were assessed. Results: A total of 465 children participated in the study (Tanner assessment N = 417, sex hormones N = 293). Assessed with self-reported Tanner, no difference in pubertal timing was found between groups (p = 0.09). Hormone levels did not differ between groups except for inhibin B (mean (SD) = 55.86 (29.13) pg/mL for FHR-SZ girls vs 84.98 (47.98) pg/mL) for PBC girls (p < 0.001)) and for follicle stimulating hormone (FSH) (mean (SD) = 5.82 (1.45) U/L for FHR-BP girls vs 4.54 (1.68) U/L for PBC girls (p < 0.001)). FHR children who were placed out of home (17 children, 3.8% of participants) had higher Tanner stages than those living at home (p < 0.001). Timing was not associated with level of problem behavior or psychiatric diagnoses. Conclusions: FHR children did not differ from controls in pubertal timing. Early life adversity assessed as placement out of home may be associated with accelerated pubertal timing among children of parents with schizophrenia or bipolar disorder.
KW - Adversity
KW - Bipolar
KW - Familial risk
KW - Puberty
KW - Schizophrenia
U2 - 10.1016/j.cpnec.2023.100204
DO - 10.1016/j.cpnec.2023.100204
M3 - Journal article
C2 - 37664528
AN - SCOPUS:85169419864
VL - 16
JO - Comprehensive Psychoneuroendocrinology
JF - Comprehensive Psychoneuroendocrinology
SN - 2666-4976
M1 - 100204
ER -
ID: 374305213