Productive vs non-productive chronic cough associated with worse lung health and higher morbidity and mortality in the general population
Publikation: Bidrag til tidsskrift › Konferenceabstrakt i tidsskrift › Forskning › fagfællebedømt
Standard
Productive vs non-productive chronic cough associated with worse lung health and higher morbidity and mortality in the general population. / Landt, E M; Çolak, Y; Nordestgaard, B; Lange, P; Dahl, M.
I: European Respiratory Journal, Bind 60, Nr. suppl 66, 4029, 2022.Publikation: Bidrag til tidsskrift › Konferenceabstrakt i tidsskrift › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - ABST
T1 - Productive vs non-productive chronic cough associated with worse lung health and higher morbidity and mortality in the general population
AU - Landt, E M
AU - Çolak, Y
AU - Nordestgaard, B
AU - Lange, P
AU - Dahl, M
PY - 2022
Y1 - 2022
N2 - Background: Whether productive or non-productive chronic cough is worse in the general population is unknown. We tested the hypothesis that productive vs non-productive chronic cough is associated with worse lung health and higher morbidity and mortality in the general population.Methods: We included 44,436 random adults from the Copenhagen General Population Study, and defined productive chronic cough as a cough lasting more than 8 weeks with mucus production during the day as long as 3 consecutive months a year. We investigated differences in lung function, accompanying respiratory symptoms, morbidity, and mortality.Results: Among 44,436 individuals, 1416 (3%) had productive chronic cough and 1380 (3%) non-productive chronic cough. Individuals with productive vs non-productive chronic cough had lower lung function (FEV1 88% vs 95% predicted, FVC 97% vs 101% predicted, and FEV1/FVC 0.72 vs 0.75), and more often accompanying respiratory symptoms (dyspnoea 5% vs 3% and wheezing 53% vs 29%), gastro-oesophageal reflux disease (36% vs 28%), and diabetes (11% vs 7%), and higher levels of inflammatory biomarkers in blood at baseline examination. Individuals with productive chronic cough vs controls had adjusted hazard ratios (HRs) of 7.2 (95% confidence interval: 4.3-12) for COPD exacerbation, 2.9 (2.2-3.8) for pneumonia, and 2.1 (1.6-2.6) for all-cause mortality. Corresponding HRs for non-productive chronic cough were 3.0 (1.4-6.2), 1.8 (1.2-2.5), and 1.5 (1.1-2.1), respectively.Conclusion: Individuals with productive versus non-productive chronic cough have worse lung health and higher risk of morbidity and mortality.
AB - Background: Whether productive or non-productive chronic cough is worse in the general population is unknown. We tested the hypothesis that productive vs non-productive chronic cough is associated with worse lung health and higher morbidity and mortality in the general population.Methods: We included 44,436 random adults from the Copenhagen General Population Study, and defined productive chronic cough as a cough lasting more than 8 weeks with mucus production during the day as long as 3 consecutive months a year. We investigated differences in lung function, accompanying respiratory symptoms, morbidity, and mortality.Results: Among 44,436 individuals, 1416 (3%) had productive chronic cough and 1380 (3%) non-productive chronic cough. Individuals with productive vs non-productive chronic cough had lower lung function (FEV1 88% vs 95% predicted, FVC 97% vs 101% predicted, and FEV1/FVC 0.72 vs 0.75), and more often accompanying respiratory symptoms (dyspnoea 5% vs 3% and wheezing 53% vs 29%), gastro-oesophageal reflux disease (36% vs 28%), and diabetes (11% vs 7%), and higher levels of inflammatory biomarkers in blood at baseline examination. Individuals with productive chronic cough vs controls had adjusted hazard ratios (HRs) of 7.2 (95% confidence interval: 4.3-12) for COPD exacerbation, 2.9 (2.2-3.8) for pneumonia, and 2.1 (1.6-2.6) for all-cause mortality. Corresponding HRs for non-productive chronic cough were 3.0 (1.4-6.2), 1.8 (1.2-2.5), and 1.5 (1.1-2.1), respectively.Conclusion: Individuals with productive versus non-productive chronic cough have worse lung health and higher risk of morbidity and mortality.
U2 - 10.1183/13993003.congress-2022.4029
DO - 10.1183/13993003.congress-2022.4029
M3 - Conference abstract in journal
VL - 60
JO - The European Respiratory Journal
JF - The European Respiratory Journal
SN - 0903-1936
IS - suppl 66
M1 - 4029
T2 - ERS International Congress 2022
Y2 - 4 September 2022 through 6 September 2022
ER -
ID: 357996643