TY - JOUR

T1 - Plasma alkylresorcinols, biomarkers of whole-grain wheat and rye intake, and incidence of colorectal cancer

AU - Kyrø, Cecilie

AU - Olsen, Anja

AU - Landberg, Rikard

AU - Skeie, Guri

AU - Loft, Steffen

AU - Åman, Per

AU - Leenders, Max

AU - Dik, Vincent K

AU - Siersema, Peter D

AU - Pischon, Tobias

AU - Christensen, Jane

AU - Overvad, Kim

AU - Boutron-Ruault, Marie-Christine

AU - Fagherazzi, Guy

AU - Cottet, Vanessa

AU - Kühn, Tilman

AU - Chang-Claude, Jenny

AU - Boeing, Heiner

AU - Trichopoulou, Antonia

AU - Bamia, Christina

AU - Trichopoulos, Dimitrios

AU - Palli, Domenico

AU - Krogh, Vittorio

AU - Tumino, Rosario

AU - Vineis, Paolo

AU - Panico, Salvatore

AU - Peeters, Petra H

AU - Weiderpass, Elisabete

AU - Bakken, Toril

AU - Åsli, Lene Angell

AU - Argüelles, Marcial

AU - Jakszyn, Paula

AU - Sánchez, María-José

AU - Amiano, Pilar

AU - Huerta, José María

AU - Barricarte, Aurelio

AU - Ljuslinder, Ingrid

AU - Palmqvist, Richard

AU - Khaw, Kay-Tee

AU - Wareham, Nick

AU - Key, Timothy J

AU - Travis, Ruth C

AU - Ferrari, Pietro

AU - Freisling, Heinz

AU - Jenab, Mazda

AU - Gunter, Marc J

AU - Murphy, Neil

AU - Riboli, Eilo

AU - Tjønneland, Anne

AU - Bueno-de-Mesquita, H B as

PY - 2014/1

Y1 - 2014/1

N2 - BACKGROUND: Few studies have investigated the association between whole-grain intake and colorectal cancer. Because whole-grain intake estimation might be prone to measurement errors, more objective measures (eg, biomarkers) could assist in investigating such associations.METHODS: The association between alkylresorcinols, biomarkers of whole-grain rye and wheat intake, and colorectal cancer incidence were investigated using prediagnostic plasma samples from colorectal cancer case patients and matched control subjects nested within the European Prospective Investigation into Cancer and Nutrition. We included 1372 incident colorectal cancer case patients and 1372 individual matched control subjects and calculated the incidence rate ratios (IRRs) for overall and anatomical subsites of colorectal cancer using conditional logistic regression adjusted for potential confounders. Regional differences (Scandinavia, the Mediterranean, Central Europe) were also explored.RESULTS: High plasma total alkylresorcinol concentration was associated with lower incidence of distal colon cancer; the adjusted incidence rate ratio of distal colon cancer for the highest vs lowest quartile of plasma total alkylresorcinols was 0.48 (95% confidence interval [CI] = 0.28 to 0.83). An inverse association between plasma total alkylresorcinol concentrations and colon cancer was found for Scandinavian participants (IRR per doubling = 0.83; 95% CI = 0.70 to 0.98). However, plasma total alkylresorcinol concentrations were not associated with overall colorectal cancer, proximal colon cancer, or rectal cancer. Plasma alkylresorcinols concentrations were associated with colon and distal colon cancer only in Central Europe and Scandinavia (ie, areas where alkylresorcinol levels were higher).CONCLUSIONS: High concentrations of plasma alkylresorcinols were associated with a lower incidence of distal colon cancer but not with overall colorectal cancer, proximal colon cancer, and rectal cancer.

AB - BACKGROUND: Few studies have investigated the association between whole-grain intake and colorectal cancer. Because whole-grain intake estimation might be prone to measurement errors, more objective measures (eg, biomarkers) could assist in investigating such associations.METHODS: The association between alkylresorcinols, biomarkers of whole-grain rye and wheat intake, and colorectal cancer incidence were investigated using prediagnostic plasma samples from colorectal cancer case patients and matched control subjects nested within the European Prospective Investigation into Cancer and Nutrition. We included 1372 incident colorectal cancer case patients and 1372 individual matched control subjects and calculated the incidence rate ratios (IRRs) for overall and anatomical subsites of colorectal cancer using conditional logistic regression adjusted for potential confounders. Regional differences (Scandinavia, the Mediterranean, Central Europe) were also explored.RESULTS: High plasma total alkylresorcinol concentration was associated with lower incidence of distal colon cancer; the adjusted incidence rate ratio of distal colon cancer for the highest vs lowest quartile of plasma total alkylresorcinols was 0.48 (95% confidence interval [CI] = 0.28 to 0.83). An inverse association between plasma total alkylresorcinol concentrations and colon cancer was found for Scandinavian participants (IRR per doubling = 0.83; 95% CI = 0.70 to 0.98). However, plasma total alkylresorcinol concentrations were not associated with overall colorectal cancer, proximal colon cancer, or rectal cancer. Plasma alkylresorcinols concentrations were associated with colon and distal colon cancer only in Central Europe and Scandinavia (ie, areas where alkylresorcinol levels were higher).CONCLUSIONS: High concentrations of plasma alkylresorcinols were associated with a lower incidence of distal colon cancer but not with overall colorectal cancer, proximal colon cancer, and rectal cancer.

KW - Aged

KW - Biological Markers

KW - Body Mass Index

KW - Case-Control Studies

KW - Colorectal Neoplasms

KW - Europe

KW - Female

KW - Food Habits

KW - Humans

KW - Incidence

KW - Logistic Models

KW - Male

KW - Mediterranean Region

KW - Middle Aged

KW - Odds Ratio

KW - Resorcinols

KW - Risk Factors

KW - Scandinavian and Nordic Countries

KW - Secale cereale

KW - Triticum

U2 - 10.1093/jnci/djt352

DO - 10.1093/jnci/djt352

M3 - Journal article

C2 - 24317181

VL - 106

SP - 1

EP - 9

JO - National Cancer Institute. Journal (Print)

JF - National Cancer Institute. Journal (Print)

SN - 0027-8874

IS - 1

M1 - djt352

ER -