Particulate matter air pollution components and risk for lung cancer

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Particulate matter air pollution components and risk for lung cancer. / Raaschou-Nielsen, O; Beelen, R; Wang, M.; Hoek, G; Andersen, Z J; Hoffmann, B; Stafoggia, M; Samoli, E; Weinmayr, G; Dimakopoulou, K; Nieuwenhuijsen, M; Xun, W W; Fischer, P; Eriksen, K T; Sørensen, M; Tjønneland, A; Ricceri, F; de Hoogh, K; Key, T; Eeftens, M; Peeters, P H; Bueno-de-Mesquita, H B; Meliefste, K; Oftedal, B; Schwarze, P E; Nafstad, P; Galassi, C; Migliore, E; Ranzi, A; Cesaroni, G; Badaloni, C; Forastiere, F; Penell, J; De Faire, U; Korek, M; Pedersen, N; Östenson, C-G; Pershagen, G; Fratiglioni, L; Concin, H; Nagel, G; Jaensch, A; Ineichen, A; Naccarati, A; Katsoulis, M; Trichpoulou, A; Keuken, M; Jedynska, A; Kooter, I M; Kukkonen, J; Brunekreef, B; Sokhi, R S; Katsouyanni, K; Vineis, P.

I: Environment International, Bind 87, 02.2016, s. 66-73.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Raaschou-Nielsen, O, Beelen, R, Wang, M, Hoek, G, Andersen, ZJ, Hoffmann, B, Stafoggia, M, Samoli, E, Weinmayr, G, Dimakopoulou, K, Nieuwenhuijsen, M, Xun, WW, Fischer, P, Eriksen, KT, Sørensen, M, Tjønneland, A, Ricceri, F, de Hoogh, K, Key, T, Eeftens, M, Peeters, PH, Bueno-de-Mesquita, HB, Meliefste, K, Oftedal, B, Schwarze, PE, Nafstad, P, Galassi, C, Migliore, E, Ranzi, A, Cesaroni, G, Badaloni, C, Forastiere, F, Penell, J, De Faire, U, Korek, M, Pedersen, N, Östenson, C-G, Pershagen, G, Fratiglioni, L, Concin, H, Nagel, G, Jaensch, A, Ineichen, A, Naccarati, A, Katsoulis, M, Trichpoulou, A, Keuken, M, Jedynska, A, Kooter, IM, Kukkonen, J, Brunekreef, B, Sokhi, RS, Katsouyanni, K & Vineis, P 2016, 'Particulate matter air pollution components and risk for lung cancer', Environment International, bind 87, s. 66-73. https://doi.org/10.1016/j.envint.2015.11.007

APA

Raaschou-Nielsen, O., Beelen, R., Wang, M., Hoek, G., Andersen, Z. J., Hoffmann, B., Stafoggia, M., Samoli, E., Weinmayr, G., Dimakopoulou, K., Nieuwenhuijsen, M., Xun, W. W., Fischer, P., Eriksen, K. T., Sørensen, M., Tjønneland, A., Ricceri, F., de Hoogh, K., Key, T., ... Vineis, P. (2016). Particulate matter air pollution components and risk for lung cancer. Environment International, 87, 66-73. https://doi.org/10.1016/j.envint.2015.11.007

Vancouver

Raaschou-Nielsen O, Beelen R, Wang M, Hoek G, Andersen ZJ, Hoffmann B o.a. Particulate matter air pollution components and risk for lung cancer. Environment International. 2016 feb.;87:66-73. https://doi.org/10.1016/j.envint.2015.11.007

Author

Raaschou-Nielsen, O ; Beelen, R ; Wang, M. ; Hoek, G ; Andersen, Z J ; Hoffmann, B ; Stafoggia, M ; Samoli, E ; Weinmayr, G ; Dimakopoulou, K ; Nieuwenhuijsen, M ; Xun, W W ; Fischer, P ; Eriksen, K T ; Sørensen, M ; Tjønneland, A ; Ricceri, F ; de Hoogh, K ; Key, T ; Eeftens, M ; Peeters, P H ; Bueno-de-Mesquita, H B ; Meliefste, K ; Oftedal, B ; Schwarze, P E ; Nafstad, P ; Galassi, C ; Migliore, E ; Ranzi, A ; Cesaroni, G ; Badaloni, C ; Forastiere, F ; Penell, J ; De Faire, U ; Korek, M ; Pedersen, N ; Östenson, C-G ; Pershagen, G ; Fratiglioni, L ; Concin, H ; Nagel, G ; Jaensch, A ; Ineichen, A ; Naccarati, A ; Katsoulis, M ; Trichpoulou, A ; Keuken, M ; Jedynska, A ; Kooter, I M ; Kukkonen, J ; Brunekreef, B ; Sokhi, R S ; Katsouyanni, K ; Vineis, P. / Particulate matter air pollution components and risk for lung cancer. I: Environment International. 2016 ; Bind 87. s. 66-73.

Bibtex

@article{693ec772ac034cfb83f1d1ce85b8780b,

title = "Particulate matter air pollution components and risk for lung cancer",

abstract = "BACKGROUND: Particulate matter (PM) air pollution is a human lung carcinogen; however, the components responsible have not been identified. We assessed the associations between PM components and lung cancer incidence.METHODS: We used data from 14 cohort studies in eight European countries. We geocoded baseline addresses and assessed air pollution with land-use regression models for eight elements (Cu, Fe, K, Ni, S, Si, V and Zn) in size fractions of PM2.5 and PM10. We used Cox regression models with adjustment for potential confounders for cohort-specific analyses and random effect models for meta-analysis.RESULTS: The 245,782 cohort members contributed 3,229,220person-years at risk. During follow-up (mean, 13.1years), 1878 incident cases of lung cancer were diagnosed. In the meta-analyses, elevated hazard ratios (HRs) for lung cancer were associated with all elements except V; none was statistically significant. In analyses restricted to participants who did not change residence during follow-up, statistically significant associations were found for PM2.5 Cu (HR, 1.25; 95% CI, 1.01-1.53 per 5ng/m(3)), PM10 Zn (1.28; 1.02-1.59 per 20ng/m(3)), PM10 S (1.58; 1.03-2.44 per 200ng/m(3)), PM10 Ni (1.59; 1.12-2.26 per 2ng/m(3)) and PM10 K (1.17; 1.02-1.33 per 100ng/m(3)). In two-pollutant models, associations between PM10 and PM2.5 and lung cancer were largely explained by PM2.5 S.CONCLUSIONS: This study indicates that the association between PM in air pollution and lung cancer can be attributed to various PM components and sources. PM containing S and Ni might be particularly important.",

author = "O Raaschou-Nielsen and R Beelen and M. Wang and G Hoek and Andersen, {Z J} and B Hoffmann and M Stafoggia and E Samoli and G Weinmayr and K Dimakopoulou and M Nieuwenhuijsen and Xun, {W W} and P Fischer and Eriksen, {K T} and M S{\o}rensen and A Tj{\o}nneland and F Ricceri and {de Hoogh}, K and T Key and M Eeftens and Peeters, {P H} and Bueno-de-Mesquita, {H B} and K Meliefste and B Oftedal and Schwarze, {P E} and P Nafstad and C Galassi and E Migliore and A Ranzi and G Cesaroni and C Badaloni and F Forastiere and J Penell and {De Faire}, U and M Korek and N Pedersen and C-G {\"O}stenson and G Pershagen and L Fratiglioni and H Concin and G Nagel and A Jaensch and A Ineichen and A Naccarati and M Katsoulis and A Trichpoulou and M Keuken and A Jedynska and Kooter, {I M} and J Kukkonen and B Brunekreef and Sokhi, {R S} and K Katsouyanni and P Vineis",

year = "2016",

month = feb,

doi = "10.1016/j.envint.2015.11.007",

language = "English",

volume = "87",

pages = "66--73",

journal = "Environment international",

issn = "0160-4120",

publisher = "Pergamon Press",

}

RIS

TY - JOUR

T1 - Particulate matter air pollution components and risk for lung cancer

AU - Raaschou-Nielsen, O

AU - Beelen, R

AU - Wang, M.

AU - Hoek, G

AU - Andersen, Z J

AU - Hoffmann, B

AU - Stafoggia, M

AU - Samoli, E

AU - Weinmayr, G

AU - Dimakopoulou, K

AU - Nieuwenhuijsen, M

AU - Xun, W W

AU - Fischer, P

AU - Eriksen, K T

AU - Sørensen, M

AU - Tjønneland, A

AU - Ricceri, F

AU - de Hoogh, K

AU - Key, T

AU - Eeftens, M

AU - Peeters, P H

AU - Bueno-de-Mesquita, H B

AU - Meliefste, K

AU - Oftedal, B

AU - Schwarze, P E

AU - Nafstad, P

AU - Galassi, C

AU - Migliore, E

AU - Ranzi, A

AU - Cesaroni, G

AU - Badaloni, C

AU - Forastiere, F

AU - Penell, J

AU - De Faire, U

AU - Korek, M

AU - Pedersen, N

AU - Östenson, C-G

AU - Pershagen, G

AU - Fratiglioni, L

AU - Concin, H

AU - Nagel, G

AU - Jaensch, A

AU - Ineichen, A

AU - Naccarati, A

AU - Katsoulis, M

AU - Trichpoulou, A

AU - Keuken, M

AU - Jedynska, A

AU - Kooter, I M

AU - Kukkonen, J

AU - Brunekreef, B

AU - Sokhi, R S

AU - Katsouyanni, K

AU - Vineis, P

PY - 2016/2

Y1 - 2016/2

N2 - BACKGROUND: Particulate matter (PM) air pollution is a human lung carcinogen; however, the components responsible have not been identified. We assessed the associations between PM components and lung cancer incidence.METHODS: We used data from 14 cohort studies in eight European countries. We geocoded baseline addresses and assessed air pollution with land-use regression models for eight elements (Cu, Fe, K, Ni, S, Si, V and Zn) in size fractions of PM2.5 and PM10. We used Cox regression models with adjustment for potential confounders for cohort-specific analyses and random effect models for meta-analysis.RESULTS: The 245,782 cohort members contributed 3,229,220person-years at risk. During follow-up (mean, 13.1years), 1878 incident cases of lung cancer were diagnosed. In the meta-analyses, elevated hazard ratios (HRs) for lung cancer were associated with all elements except V; none was statistically significant. In analyses restricted to participants who did not change residence during follow-up, statistically significant associations were found for PM2.5 Cu (HR, 1.25; 95% CI, 1.01-1.53 per 5ng/m(3)), PM10 Zn (1.28; 1.02-1.59 per 20ng/m(3)), PM10 S (1.58; 1.03-2.44 per 200ng/m(3)), PM10 Ni (1.59; 1.12-2.26 per 2ng/m(3)) and PM10 K (1.17; 1.02-1.33 per 100ng/m(3)). In two-pollutant models, associations between PM10 and PM2.5 and lung cancer were largely explained by PM2.5 S.CONCLUSIONS: This study indicates that the association between PM in air pollution and lung cancer can be attributed to various PM components and sources. PM containing S and Ni might be particularly important.

AB - BACKGROUND: Particulate matter (PM) air pollution is a human lung carcinogen; however, the components responsible have not been identified. We assessed the associations between PM components and lung cancer incidence.METHODS: We used data from 14 cohort studies in eight European countries. We geocoded baseline addresses and assessed air pollution with land-use regression models for eight elements (Cu, Fe, K, Ni, S, Si, V and Zn) in size fractions of PM2.5 and PM10. We used Cox regression models with adjustment for potential confounders for cohort-specific analyses and random effect models for meta-analysis.RESULTS: The 245,782 cohort members contributed 3,229,220person-years at risk. During follow-up (mean, 13.1years), 1878 incident cases of lung cancer were diagnosed. In the meta-analyses, elevated hazard ratios (HRs) for lung cancer were associated with all elements except V; none was statistically significant. In analyses restricted to participants who did not change residence during follow-up, statistically significant associations were found for PM2.5 Cu (HR, 1.25; 95% CI, 1.01-1.53 per 5ng/m(3)), PM10 Zn (1.28; 1.02-1.59 per 20ng/m(3)), PM10 S (1.58; 1.03-2.44 per 200ng/m(3)), PM10 Ni (1.59; 1.12-2.26 per 2ng/m(3)) and PM10 K (1.17; 1.02-1.33 per 100ng/m(3)). In two-pollutant models, associations between PM10 and PM2.5 and lung cancer were largely explained by PM2.5 S.CONCLUSIONS: This study indicates that the association between PM in air pollution and lung cancer can be attributed to various PM components and sources. PM containing S and Ni might be particularly important.

U2 - 10.1016/j.envint.2015.11.007

DO - 10.1016/j.envint.2015.11.007

M3 - Journal article

C2 - 26641521

VL - 87

SP - 66

EP - 73

JO - Environment international

JF - Environment international

SN - 0160-4120

ER -

ID: 150781498