Obstetric and neonatal complications in pregnancies conceived after oocyte donation: a systematic review and meta-analysis

Publikation: Bidrag til tidsskriftReviewForskningfagfællebedømt

Standard

Obstetric and neonatal complications in pregnancies conceived after oocyte donation : a systematic review and meta-analysis. / Storgaard, M.; Loft, A.; Bergh, C.; Wennerholm, UB; Söderström-Anttila, V.; Romundstad, LB; Aittomaki, K.; Oldereid, N.; Forman, J.; Pinborg, A.

I: BJOG: An International Journal of Obstetrics and Gynaecology, Bind 124, Nr. 4, 03.2017, s. 561–572.

Publikation: Bidrag til tidsskriftReviewForskningfagfællebedømt

Harvard

Storgaard, M, Loft, A, Bergh, C, Wennerholm, UB, Söderström-Anttila, V, Romundstad, LB, Aittomaki, K, Oldereid, N, Forman, J & Pinborg, A 2017, 'Obstetric and neonatal complications in pregnancies conceived after oocyte donation: a systematic review and meta-analysis', BJOG: An International Journal of Obstetrics and Gynaecology, bind 124, nr. 4, s. 561–572. https://doi.org/10.1111/1471-0528.14257

APA

Storgaard, M., Loft, A., Bergh, C., Wennerholm, UB., Söderström-Anttila, V., Romundstad, LB., ... Pinborg, A. (2017). Obstetric and neonatal complications in pregnancies conceived after oocyte donation: a systematic review and meta-analysis. BJOG: An International Journal of Obstetrics and Gynaecology, 124(4), 561–572. https://doi.org/10.1111/1471-0528.14257

Vancouver

Storgaard M, Loft A, Bergh C, Wennerholm UB, Söderström-Anttila V, Romundstad LB o.a. Obstetric and neonatal complications in pregnancies conceived after oocyte donation: a systematic review and meta-analysis. BJOG: An International Journal of Obstetrics and Gynaecology. 2017 mar;124(4):561–572. https://doi.org/10.1111/1471-0528.14257

Author

Storgaard, M. ; Loft, A. ; Bergh, C. ; Wennerholm, UB ; Söderström-Anttila, V. ; Romundstad, LB ; Aittomaki, K. ; Oldereid, N. ; Forman, J. ; Pinborg, A. / Obstetric and neonatal complications in pregnancies conceived after oocyte donation : a systematic review and meta-analysis. I: BJOG: An International Journal of Obstetrics and Gynaecology. 2017 ; Bind 124, Nr. 4. s. 561–572.

Bibtex

@article{70a7ad927c664244b7c76f566b4a6a80,
title = "Obstetric and neonatal complications in pregnancies conceived after oocyte donation: a systematic review and meta-analysis",
abstract = "Background: Approximately 50 000 oocyte donation (OD) treatment cycles are now performed annually in Europe and the US.Objectives: To ascertain whether the risk of adverse obstetric and perinatal/neonatal outcomes is higher in pregnancies conceived by OD than in pregnancies conceived by conventional in-vitro fertilisation (IVF)/intracytoplasmic sperm injection (ICSI) or spontaneously.Search Strategy: A systematic search was performed in the PubMed, Cochrane and Embase databases from 1982–2016. Primary outcomes were hypertensive disorders of pregnancy, pre-eclampsia (PE), gestational diabetes mellitus, postpartum haemorrhage, caesarean section, preterm birth, low birthweight and small for gestational age.Selection criteria: Inclusion criteria were original studies including at least five OD pregnancies with a control group of pregnancies conceived by conventional IVF/ICSI or spontaneous conception, and case series with >500 cases reporting one or more of the selected complications. Studies not adjusting for plurality were excluded.Data collection and analysis: Thirty-five studies met the inclusion criteria. A random-effects model was used for the meta-analyses.Main results: For OD pregnancies versus conventional IVF/ICSI pregnancies the risk of PE was adjusted odds ratio (AOR) 2.11 (95{\%} CI, 1.42–3.15) in singleton and AOR 3.31 (95{\%} CI, 1.61–6.80) in multiple pregnancies. The risks of preterm birth and low birthweight in singletons were AOR 1.75 (95{\%} CI, 1.39–2.20) and 1.53 (95{\%} CI, 1.16–2.01), respectively.Conclusions: OD conceptions are associated with adverse obstetric and neonatal outcomes. To avoid the additional increase in risk from multiplicity, single-embryo transfer should be the choice of option in OD cycles.",
keywords = "Caesarean section, Low birthweight, Oocyte donation, Pre-eclampsia, Preterm birth",
author = "M. Storgaard and A. Loft and C. Bergh and UB Wennerholm and V. S{\"o}derstr{\"o}m-Anttila and LB Romundstad and K. Aittomaki and N. Oldereid and J. Forman and A. Pinborg",
year = "2017",
month = "3",
doi = "10.1111/1471-0528.14257",
language = "English",
volume = "124",
pages = "561–572",
journal = "B J O G",
issn = "1470-0328",
publisher = "Wiley-Blackwell",
number = "4",

}

RIS

TY - JOUR

T1 - Obstetric and neonatal complications in pregnancies conceived after oocyte donation

T2 - a systematic review and meta-analysis

AU - Storgaard, M.

AU - Loft, A.

AU - Bergh, C.

AU - Wennerholm, UB

AU - Söderström-Anttila, V.

AU - Romundstad, LB

AU - Aittomaki, K.

AU - Oldereid, N.

AU - Forman, J.

AU - Pinborg, A.

PY - 2017/3

Y1 - 2017/3

N2 - Background: Approximately 50 000 oocyte donation (OD) treatment cycles are now performed annually in Europe and the US.Objectives: To ascertain whether the risk of adverse obstetric and perinatal/neonatal outcomes is higher in pregnancies conceived by OD than in pregnancies conceived by conventional in-vitro fertilisation (IVF)/intracytoplasmic sperm injection (ICSI) or spontaneously.Search Strategy: A systematic search was performed in the PubMed, Cochrane and Embase databases from 1982–2016. Primary outcomes were hypertensive disorders of pregnancy, pre-eclampsia (PE), gestational diabetes mellitus, postpartum haemorrhage, caesarean section, preterm birth, low birthweight and small for gestational age.Selection criteria: Inclusion criteria were original studies including at least five OD pregnancies with a control group of pregnancies conceived by conventional IVF/ICSI or spontaneous conception, and case series with >500 cases reporting one or more of the selected complications. Studies not adjusting for plurality were excluded.Data collection and analysis: Thirty-five studies met the inclusion criteria. A random-effects model was used for the meta-analyses.Main results: For OD pregnancies versus conventional IVF/ICSI pregnancies the risk of PE was adjusted odds ratio (AOR) 2.11 (95% CI, 1.42–3.15) in singleton and AOR 3.31 (95% CI, 1.61–6.80) in multiple pregnancies. The risks of preterm birth and low birthweight in singletons were AOR 1.75 (95% CI, 1.39–2.20) and 1.53 (95% CI, 1.16–2.01), respectively.Conclusions: OD conceptions are associated with adverse obstetric and neonatal outcomes. To avoid the additional increase in risk from multiplicity, single-embryo transfer should be the choice of option in OD cycles.

AB - Background: Approximately 50 000 oocyte donation (OD) treatment cycles are now performed annually in Europe and the US.Objectives: To ascertain whether the risk of adverse obstetric and perinatal/neonatal outcomes is higher in pregnancies conceived by OD than in pregnancies conceived by conventional in-vitro fertilisation (IVF)/intracytoplasmic sperm injection (ICSI) or spontaneously.Search Strategy: A systematic search was performed in the PubMed, Cochrane and Embase databases from 1982–2016. Primary outcomes were hypertensive disorders of pregnancy, pre-eclampsia (PE), gestational diabetes mellitus, postpartum haemorrhage, caesarean section, preterm birth, low birthweight and small for gestational age.Selection criteria: Inclusion criteria were original studies including at least five OD pregnancies with a control group of pregnancies conceived by conventional IVF/ICSI or spontaneous conception, and case series with >500 cases reporting one or more of the selected complications. Studies not adjusting for plurality were excluded.Data collection and analysis: Thirty-five studies met the inclusion criteria. A random-effects model was used for the meta-analyses.Main results: For OD pregnancies versus conventional IVF/ICSI pregnancies the risk of PE was adjusted odds ratio (AOR) 2.11 (95% CI, 1.42–3.15) in singleton and AOR 3.31 (95% CI, 1.61–6.80) in multiple pregnancies. The risks of preterm birth and low birthweight in singletons were AOR 1.75 (95% CI, 1.39–2.20) and 1.53 (95% CI, 1.16–2.01), respectively.Conclusions: OD conceptions are associated with adverse obstetric and neonatal outcomes. To avoid the additional increase in risk from multiplicity, single-embryo transfer should be the choice of option in OD cycles.

KW - Caesarean section

KW - Low birthweight

KW - Oocyte donation

KW - Pre-eclampsia

KW - Preterm birth

U2 - 10.1111/1471-0528.14257

DO - 10.1111/1471-0528.14257

M3 - Review

C2 - 27592694

VL - 124

SP - 561

EP - 572

JO - B J O G

JF - B J O G

SN - 1470-0328

IS - 4

ER -

ID: 172470938