Number of Traumatic brain injuries and temporal associations with depression: A register-based cohort study
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Number of Traumatic brain injuries and temporal associations with depression : A register-based cohort study. / Eliasen, Marie Holm; Petersen, Janne; Benros, Michael Eriksen; Osler, Merete.
I: Acta Psychiatrica Scandinavica, Bind 144, Nr. 4, 2021, s. 407-414.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Number of Traumatic brain injuries and temporal associations with depression
T2 - A register-based cohort study
AU - Eliasen, Marie Holm
AU - Petersen, Janne
AU - Benros, Michael Eriksen
AU - Osler, Merete
N1 - This article is protected by copyright. All rights reserved.
PY - 2021
Y1 - 2021
N2 - OBJECTIVE: To explore the association of the number of TBIs and temporal associations with the subsequent risk of depression in the population.METHODS: National register-based cohort study on all individuals registered with TBI (ICD-10: S06, ICD-8: 85.0-85.5) from 1977 to 2015 in Denmark (n=494,216) and a sex- and age-matched reference population (n=499,505). The associations with the number of TBIs and time to depression (0-6, 7-12 and more than 12 months following TBI) were analyzed using Cox proportional hazard regression.RESULTS: During a follow-up of mean 14.5 (SD 11.3) years, a total of 27,873 (5.6%) individuals who had at least one TBI and 15,195 (3.0%) in the reference population were diagnosed with a depression. First-time TBI was associated with a higher risk of depression in both men (HR=1.73 (95% CI:1.67-1.79)) and women (HR=1.66 (95% CI:1.61-1.70)) after multiple adjustments for educational status and comorbidities including previous depression, and the association became stronger in a dose-response association with the number of TBIs (test for trend p<0.01). The HRs for depression were highest the first 6 month after the TBI in both men (HR=5.69 (95% CI:4.66-6.94)) and women (HR=4.55 (95% CI:3.93-5.26)) and decreased gradually the following year but remained elevated from one year after TBI until end of follow-up independent of the number of TBIs (p<0.01). The associations did not vary with age or calender time.CONCLUSION: TBI is associated with a higher risk of depression, especially in the first months after TBI and the risk increases with the number of TBIs.
AB - OBJECTIVE: To explore the association of the number of TBIs and temporal associations with the subsequent risk of depression in the population.METHODS: National register-based cohort study on all individuals registered with TBI (ICD-10: S06, ICD-8: 85.0-85.5) from 1977 to 2015 in Denmark (n=494,216) and a sex- and age-matched reference population (n=499,505). The associations with the number of TBIs and time to depression (0-6, 7-12 and more than 12 months following TBI) were analyzed using Cox proportional hazard regression.RESULTS: During a follow-up of mean 14.5 (SD 11.3) years, a total of 27,873 (5.6%) individuals who had at least one TBI and 15,195 (3.0%) in the reference population were diagnosed with a depression. First-time TBI was associated with a higher risk of depression in both men (HR=1.73 (95% CI:1.67-1.79)) and women (HR=1.66 (95% CI:1.61-1.70)) after multiple adjustments for educational status and comorbidities including previous depression, and the association became stronger in a dose-response association with the number of TBIs (test for trend p<0.01). The HRs for depression were highest the first 6 month after the TBI in both men (HR=5.69 (95% CI:4.66-6.94)) and women (HR=4.55 (95% CI:3.93-5.26)) and decreased gradually the following year but remained elevated from one year after TBI until end of follow-up independent of the number of TBIs (p<0.01). The associations did not vary with age or calender time.CONCLUSION: TBI is associated with a higher risk of depression, especially in the first months after TBI and the risk increases with the number of TBIs.
U2 - 10.1111/acps.13347
DO - 10.1111/acps.13347
M3 - Journal article
C2 - 34231201
VL - 144
SP - 407
EP - 414
JO - Acta Psychiatrica Scandinavica
JF - Acta Psychiatrica Scandinavica
SN - 0001-690X
IS - 4
ER -
ID: 274135198