New-onset atrial fibrillation in the intensive care unit: Protocol for an international inception cohort study (AFIB-ICU)
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New-onset atrial fibrillation in the intensive care unit : Protocol for an international inception cohort study (AFIB-ICU). / Wetterslev, Mik; Moller, Morten Hylander; Granholm, Anders; Haase, Nicolai; Hassager, Christian; Lange, Theis; Hastbacka, Johanna; Wilkman, Erika; Myatra, Sheila Nainan; Shen, Jiawei; An, Youzhong; Siegemund, Martin; Young, Paul J.; Aslam, Tayyba N.; Szczeklik, Wojciech; Aneman, Anders; Arabi, Yaseen M.; Cronhjort, Maria; Keus, Frederik; Perner, Anders.
I: Acta Anaesthesiologica Scandinavica, Bind 65, Nr. 6, 2021, s. 846-851.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - New-onset atrial fibrillation in the intensive care unit
T2 - Protocol for an international inception cohort study (AFIB-ICU)
AU - Wetterslev, Mik
AU - Moller, Morten Hylander
AU - Granholm, Anders
AU - Haase, Nicolai
AU - Hassager, Christian
AU - Lange, Theis
AU - Hastbacka, Johanna
AU - Wilkman, Erika
AU - Myatra, Sheila Nainan
AU - Shen, Jiawei
AU - An, Youzhong
AU - Siegemund, Martin
AU - Young, Paul J.
AU - Aslam, Tayyba N.
AU - Szczeklik, Wojciech
AU - Aneman, Anders
AU - Arabi, Yaseen M.
AU - Cronhjort, Maria
AU - Keus, Frederik
AU - Perner, Anders
PY - 2021
Y1 - 2021
N2 - Introduction New-onset atrial fibrillation (NOAF) is frequently observed in critically ill patients and may be associated with prolonged hospital stay and increased mortality. Considerable variation exists in the reported frequencies of NOAF due to the lack of a standardised definition and detection method. Importantly, there are limited data on NOAF in the intensive care unit (ICU). Thus, we aim to provide contemporary epidemiological data on NOAF in the ICU.Methods and Analysis We have designed an international inception cohort study including at least 1,000 consecutive adult patients acutely admitted to the ICU without prior history of persistent or permanent AF. We will present data on the incidence, risk factors, used management strategies and outcomes of NOAF. We will register data daily during stay in the ICU for a maximum of 90 days after admission. The incidence of NOAF and management strategies used will be presented descriptively, and we will use Cox regression analyses including competing risk analyses to assess risk factors for NOAF and any association with 90-day mortality.Conclusion The outlined international AFIB-ICU inception cohort study will provide contemporary data on the incidence, risk factors, used management strategies and outcomes of NOAF in adult ICU patients.Ethics and dissemination This observational study poses no risk to the included patients. All participating sites will obtain relevant approvals according to national laws before patient enrollment. Funding sources will have no influence on data handling, analyses or writing of the manuscript. The study report(s) will be submitted to an international peer-reviewed journal.
AB - Introduction New-onset atrial fibrillation (NOAF) is frequently observed in critically ill patients and may be associated with prolonged hospital stay and increased mortality. Considerable variation exists in the reported frequencies of NOAF due to the lack of a standardised definition and detection method. Importantly, there are limited data on NOAF in the intensive care unit (ICU). Thus, we aim to provide contemporary epidemiological data on NOAF in the ICU.Methods and Analysis We have designed an international inception cohort study including at least 1,000 consecutive adult patients acutely admitted to the ICU without prior history of persistent or permanent AF. We will present data on the incidence, risk factors, used management strategies and outcomes of NOAF. We will register data daily during stay in the ICU for a maximum of 90 days after admission. The incidence of NOAF and management strategies used will be presented descriptively, and we will use Cox regression analyses including competing risk analyses to assess risk factors for NOAF and any association with 90-day mortality.Conclusion The outlined international AFIB-ICU inception cohort study will provide contemporary data on the incidence, risk factors, used management strategies and outcomes of NOAF in adult ICU patients.Ethics and dissemination This observational study poses no risk to the included patients. All participating sites will obtain relevant approvals according to national laws before patient enrollment. Funding sources will have no influence on data handling, analyses or writing of the manuscript. The study report(s) will be submitted to an international peer-reviewed journal.
U2 - 10.1111/aas.13827
DO - 10.1111/aas.13827
M3 - Journal article
C2 - 33864378
VL - 65
SP - 846
EP - 851
JO - Acta Anaesthesiologica Scandinavica
JF - Acta Anaesthesiologica Scandinavica
SN - 0001-5172
IS - 6
ER -
ID: 261565485