New-onset atrial fibrillation: Incidence, characteristics, and related events following a national COVID-19 lockdown of 5.6 million people
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
New-onset atrial fibrillation : Incidence, characteristics, and related events following a national COVID-19 lockdown of 5.6 million people. / Holt, Anders; Gislason, Gunnar H.; Schou, Morten; Zareini, Bochra; Biering-Sørensen, Tor; Phelps, Matthew; Kragholm, Kristian; Andersson, Charlotte; Fosbøl, Emil L.; Hansen, Morten Lock; Gerds, Thomas A.; Køber, Lars; Torp-Pedersen, Christian; Lamberts, Morten.
I: European Heart Journal, Bind 41, Nr. 32, 2020, s. 3072-3079.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - New-onset atrial fibrillation
T2 - Incidence, characteristics, and related events following a national COVID-19 lockdown of 5.6 million people
AU - Holt, Anders
AU - Gislason, Gunnar H.
AU - Schou, Morten
AU - Zareini, Bochra
AU - Biering-Sørensen, Tor
AU - Phelps, Matthew
AU - Kragholm, Kristian
AU - Andersson, Charlotte
AU - Fosbøl, Emil L.
AU - Hansen, Morten Lock
AU - Gerds, Thomas A.
AU - Køber, Lars
AU - Torp-Pedersen, Christian
AU - Lamberts, Morten
PY - 2020
Y1 - 2020
N2 - Aim To determine the incidence, patient characteristics, and related events associated with new-onset atrial fibrillation (AF) during a national COVID-19 lockdown. Methods Using nationwide Danish registries, we included all patients, aged 18-90 years, receiving a new-onset AF diagnosis and results during the first 3 months of 2019 and 2020. The main comparison was between patients diagnosed during lockdown (12 March 12-1 April 2020) and patients diagnosed in the corresponding period 1 year previously. We found a lower incidence of new-onset AF during the 3 weeks of lockdown compared with the corresponding weeks in 2019 [incidence rate ratios with 95% confidence intervals (CIs) for the 3 weeks: 0.66 (0.56-0.78), 0.53 (0.45-0.64), and 0.41 (0.34-0.50)]. There was a 47% drop in total numbers (562 vs. 1053). Patients diagnosed during lockdown were younger and with a lower CHA2DS2-VASc score, while history of cancer, heart failure, and vascular disease were more prevalent. During lockdown, 30 (5.3%) patients with new-onset AF suffered an ischaemic stroke and 15 (2.7%) died, compared with 45 (4.3%) and 14 (1.3%) patients during the corresponding 2019 period, respectively. The adjusted odds ratio of a related event (ischaemic stroke or all-cause death) during lock-down compared with the corresponding weeks was 1.41 (95% CI 0.93-2.12). Conclusions Following a national lockdown in Denmark, a 47% drop in registered new-onset AF cases was observed. In the event of prolonged or subsequent lockdowns, the risk of undiagnosed AF patients developing complications could potentially translate into poorer outcomes in patients with AF during the COVID-19 pandemic.
AB - Aim To determine the incidence, patient characteristics, and related events associated with new-onset atrial fibrillation (AF) during a national COVID-19 lockdown. Methods Using nationwide Danish registries, we included all patients, aged 18-90 years, receiving a new-onset AF diagnosis and results during the first 3 months of 2019 and 2020. The main comparison was between patients diagnosed during lockdown (12 March 12-1 April 2020) and patients diagnosed in the corresponding period 1 year previously. We found a lower incidence of new-onset AF during the 3 weeks of lockdown compared with the corresponding weeks in 2019 [incidence rate ratios with 95% confidence intervals (CIs) for the 3 weeks: 0.66 (0.56-0.78), 0.53 (0.45-0.64), and 0.41 (0.34-0.50)]. There was a 47% drop in total numbers (562 vs. 1053). Patients diagnosed during lockdown were younger and with a lower CHA2DS2-VASc score, while history of cancer, heart failure, and vascular disease were more prevalent. During lockdown, 30 (5.3%) patients with new-onset AF suffered an ischaemic stroke and 15 (2.7%) died, compared with 45 (4.3%) and 14 (1.3%) patients during the corresponding 2019 period, respectively. The adjusted odds ratio of a related event (ischaemic stroke or all-cause death) during lock-down compared with the corresponding weeks was 1.41 (95% CI 0.93-2.12). Conclusions Following a national lockdown in Denmark, a 47% drop in registered new-onset AF cases was observed. In the event of prolonged or subsequent lockdowns, the risk of undiagnosed AF patients developing complications could potentially translate into poorer outcomes in patients with AF during the COVID-19 pandemic.
KW - Atrial fibrillation
KW - Collateral damage
KW - COVID-19 pandemic
KW - National lockdown
U2 - 10.1093/eurheartj/ehaa494
DO - 10.1093/eurheartj/ehaa494
M3 - Journal article
C2 - 32578859
AN - SCOPUS:85089270157
VL - 41
SP - 3072
EP - 3079
JO - European Heart Journal
JF - European Heart Journal
SN - 0195-668X
IS - 32
ER -
ID: 251579343