Multiple myeloma risk in relation to long-term air pollution exposure - A pooled analysis of four European cohorts

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  • Ulla Arthur Hvidtfeldt
  • Jie Chen
  • Sophia Rodopoulou
  • Maciej Strak
  • Kees de Hoogh
  • Tom Bellander
  • Jørgen Brandt
  • Francesco Forastiere
  • Boel Brynedal
  • Ole Hertel
  • Barbara Hoffmann
  • Klea Katsouyanni
  • Matthias Ketzel
  • Karin Leander
  • Patrik K E Magnusson
  • Gabriele Nagel
  • Göran Pershagen
  • Debora Rizzuto
  • Evangelia Samoli
  • Massimo Stafoggia
  • Gudrun Weinmayr
  • Kathrin Wolf
  • Emanuel Zitt
  • Bert Brunekreef
  • Gerard Hoek
  • Ole Raaschou-Nielsen
Air pollution is a growing concern worldwide, with significant impacts on human health. Multiple myeloma is a type of blood cancer with increasing incidence. Studies have linked air pollution exposure to various types of cancer, including leukemia and lymphoma, however, the relationship with multiple myeloma incidence has not been extensively investigated.

We pooled four European cohorts (N = 234,803) and assessed the association between residential exposure to nitrogen dioxide (NO2), fine particles (PM2.5), black carbon (BC), and ozone (O3) and multiple myeloma. We applied Cox proportional hazards models adjusting for potential confounders at the individual and area-level.

During 4,415,817 person-years of follow-up (average 18.8 years), we observed 404 cases of multiple myeloma. The results of the fully adjusted linear analyses showed hazard ratios (95% confidence interval) of 0.99 (0.84, 1.16) per 10 μg/m³ NO2, 1.04 (0.82, 1.33) per 5 μg/m³ PM2.5, 0.99 (0.84, 1.18) per 0.5 10−5 m−1 BCE, and 1.11 (0.87, 1.41) per 10 μg/m³ O3.

We did not observe an association between long-term ambient air pollution exposure and incidence of multiple myeloma.
TidsskriftEnvironmental Research
Udgave nummerPt 1
Antal sider7
StatusUdgivet - 2023

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