Mortality and HRQoL in ICU patients with delirium: Protocol for 1-year follow-up of AID-ICU trial
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Mortality and HRQoL in ICU patients with delirium : Protocol for 1-year follow-up of AID-ICU trial. / Mortensen, Camilla B.; Poulsen, Lone M.; Andersen-Ranberg, Nina C.; Perner, Anders; Lange, Theis; Estrup, Stine S.; Ebdrup, Bjørn H.; Egerod, Ingrid; Rasmussen, Bodil S.; Hastbacka, Johanna; Caballero, Jesus; Citerio, Giuseppe; Morgan, Matthew P. G.; Samuelson, Karin; Mathiesen, Ole.
I: Acta Anaesthesiologica Scandinavica, Bind 64, Nr. 10, 2020, s. 1519-1525.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Mortality and HRQoL in ICU patients with delirium
T2 - Protocol for 1-year follow-up of AID-ICU trial
AU - Mortensen, Camilla B.
AU - Poulsen, Lone M.
AU - Andersen-Ranberg, Nina C.
AU - Perner, Anders
AU - Lange, Theis
AU - Estrup, Stine S.
AU - Ebdrup, Bjørn H.
AU - Egerod, Ingrid
AU - Rasmussen, Bodil S.
AU - Hastbacka, Johanna
AU - Caballero, Jesus
AU - Citerio, Giuseppe
AU - Morgan, Matthew P. G.
AU - Samuelson, Karin
AU - Mathiesen, Ole
PY - 2020
Y1 - 2020
N2 - Background Intensive care unit (ICU)-acquired delirium is frequent and associated with poor short- and long-term outcomes for patients in ICUs. It therefore constitutes a major healthcare problem. Despite limited evidence, haloperidol is the most frequently used pharmacological intervention against ICU-acquired delirium. Agents intervening against Delirium in the ICU (AID-ICU) is an international, multicentre, randomised, blinded, placebo-controlled trial investigates benefits and harms of treatment with haloperidol in patients with ICU-acquired delirium. The current pre-planned one-year follow-up study of the AID-ICU trial population aims to explore the effects of haloperidol on one-year mortality and health related quality of life (HRQoL). Methods The AID-ICU trial will include 1000 participants. One-year mortality will be obtained from the trial sites; we will validate the vital status of Danish participants using the Danish National Health Data Registers. Mortality will be analysed by Cox-regression and visualized by Kaplan-Meier curves tested for significance using the log-rank test. We will obtain HRQoL data using the EQ-5D instrument. HRQoL analysis will be performed using a general linear model adjusted for stratification variables. Deceased participants will be designated the worst possible value. Results We expect to publish results of this study in 2022. Conclusion We expect that this one-year follow-up study of participants with ICU-acquired delirium allocated to haloperidol vs. placebo will provide important information on the long-term consequences of delirium including the effects of haloperidol. We expect that our results will improve the care of this vulnerable patient group.
AB - Background Intensive care unit (ICU)-acquired delirium is frequent and associated with poor short- and long-term outcomes for patients in ICUs. It therefore constitutes a major healthcare problem. Despite limited evidence, haloperidol is the most frequently used pharmacological intervention against ICU-acquired delirium. Agents intervening against Delirium in the ICU (AID-ICU) is an international, multicentre, randomised, blinded, placebo-controlled trial investigates benefits and harms of treatment with haloperidol in patients with ICU-acquired delirium. The current pre-planned one-year follow-up study of the AID-ICU trial population aims to explore the effects of haloperidol on one-year mortality and health related quality of life (HRQoL). Methods The AID-ICU trial will include 1000 participants. One-year mortality will be obtained from the trial sites; we will validate the vital status of Danish participants using the Danish National Health Data Registers. Mortality will be analysed by Cox-regression and visualized by Kaplan-Meier curves tested for significance using the log-rank test. We will obtain HRQoL data using the EQ-5D instrument. HRQoL analysis will be performed using a general linear model adjusted for stratification variables. Deceased participants will be designated the worst possible value. Results We expect to publish results of this study in 2022. Conclusion We expect that this one-year follow-up study of participants with ICU-acquired delirium allocated to haloperidol vs. placebo will provide important information on the long-term consequences of delirium including the effects of haloperidol. We expect that our results will improve the care of this vulnerable patient group.
KW - QUALITY-OF-LIFE
KW - MECHANICALLY VENTILATED PATIENTS
KW - SURVIVAL
KW - HALOPERIDOL
KW - PREDICTOR
KW - RISK
U2 - 10.1111/aas.13679
DO - 10.1111/aas.13679
M3 - Journal article
C2 - 33460045
VL - 64
SP - 1519
EP - 1525
JO - Acta Anaesthesiologica Scandinavica
JF - Acta Anaesthesiologica Scandinavica
SN - 0001-5172
IS - 10
ER -
ID: 247684347