Morphostereometry of heterotopic ossicles in the rat

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Standard

Morphostereometry of heterotopic ossicles in the rat. / Mohr, H; Kragstrup, J.

I: Acta Orthopaedica Scandinavica, Bind 62, Nr. 3, 06.1991, s. 257-60.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Mohr, H & Kragstrup, J 1991, 'Morphostereometry of heterotopic ossicles in the rat', Acta Orthopaedica Scandinavica, bind 62, nr. 3, s. 257-60. https://doi.org/10.3109/17453679108993604

APA

Mohr, H., & Kragstrup, J. (1991). Morphostereometry of heterotopic ossicles in the rat. Acta Orthopaedica Scandinavica, 62(3), 257-60. https://doi.org/10.3109/17453679108993604

Vancouver

Mohr H, Kragstrup J. Morphostereometry of heterotopic ossicles in the rat. Acta Orthopaedica Scandinavica. 1991 jun.;62(3):257-60. https://doi.org/10.3109/17453679108993604

Author

Mohr, H ; Kragstrup, J. / Morphostereometry of heterotopic ossicles in the rat. I: Acta Orthopaedica Scandinavica. 1991 ; Bind 62, Nr. 3. s. 257-60.

Bibtex

@article{3f822dbbee034af5a068a823181c84e9,
title = "Morphostereometry of heterotopic ossicles in the rat",
abstract = "The objective of this study was to describe induced heterotopic bone formation in the rat using stereologic methods and to optimize the sampling for toxicologic studies. Bone formation was induced by implants of demineralized bone powder in 24 male Wistar rats. The ossicles formed were removed after 14, 16, 17, 18, and 20 days. From each ossicle, six sections were sampled equidistantly, and seven microscopic fields were analyzed in each section. Ossicle volume and weight decreased from Day 16 to Day 20. Bone volume density increased during the experimental period because of the reduction in ossicle volume, whereas the total bone volume did not change. Bone thickness increased from Day 14 to Day 20. No changes were observed in the surface density and total area of formative surfaces. The major part of the total variation was due to true variation between animals. The described histomorphometric methods may prove useful in quantitative toxicologic studies, e.g., of fluoride effects on cartilage and bone formation.",
keywords = "Analysis of Variance, Animals, Biomechanical Phenomena, Bone Development/drug effects, Bone and Bones/pathology, Cartilage/drug effects, Histological Techniques, Male, Ossification, Heterotopic/pathology, Rats, Rats, Inbred Strains, Surface Properties, Toxicology",
author = "H Mohr and J Kragstrup",
year = "1991",
month = jun,
doi = "10.3109/17453679108993604",
language = "English",
volume = "62",
pages = "257--60",
journal = "Acta Orthopaedica Scandinavica",
issn = "0001-6470",
publisher = "Taylor & Francis",
number = "3",

}

RIS

TY - JOUR

T1 - Morphostereometry of heterotopic ossicles in the rat

AU - Mohr, H

AU - Kragstrup, J

PY - 1991/6

Y1 - 1991/6

N2 - The objective of this study was to describe induced heterotopic bone formation in the rat using stereologic methods and to optimize the sampling for toxicologic studies. Bone formation was induced by implants of demineralized bone powder in 24 male Wistar rats. The ossicles formed were removed after 14, 16, 17, 18, and 20 days. From each ossicle, six sections were sampled equidistantly, and seven microscopic fields were analyzed in each section. Ossicle volume and weight decreased from Day 16 to Day 20. Bone volume density increased during the experimental period because of the reduction in ossicle volume, whereas the total bone volume did not change. Bone thickness increased from Day 14 to Day 20. No changes were observed in the surface density and total area of formative surfaces. The major part of the total variation was due to true variation between animals. The described histomorphometric methods may prove useful in quantitative toxicologic studies, e.g., of fluoride effects on cartilage and bone formation.

AB - The objective of this study was to describe induced heterotopic bone formation in the rat using stereologic methods and to optimize the sampling for toxicologic studies. Bone formation was induced by implants of demineralized bone powder in 24 male Wistar rats. The ossicles formed were removed after 14, 16, 17, 18, and 20 days. From each ossicle, six sections were sampled equidistantly, and seven microscopic fields were analyzed in each section. Ossicle volume and weight decreased from Day 16 to Day 20. Bone volume density increased during the experimental period because of the reduction in ossicle volume, whereas the total bone volume did not change. Bone thickness increased from Day 14 to Day 20. No changes were observed in the surface density and total area of formative surfaces. The major part of the total variation was due to true variation between animals. The described histomorphometric methods may prove useful in quantitative toxicologic studies, e.g., of fluoride effects on cartilage and bone formation.

KW - Analysis of Variance

KW - Animals

KW - Biomechanical Phenomena

KW - Bone Development/drug effects

KW - Bone and Bones/pathology

KW - Cartilage/drug effects

KW - Histological Techniques

KW - Male

KW - Ossification, Heterotopic/pathology

KW - Rats

KW - Rats, Inbred Strains

KW - Surface Properties

KW - Toxicology

U2 - 10.3109/17453679108993604

DO - 10.3109/17453679108993604

M3 - Journal article

C2 - 1904184

VL - 62

SP - 257

EP - 260

JO - Acta Orthopaedica Scandinavica

JF - Acta Orthopaedica Scandinavica

SN - 0001-6470

IS - 3

ER -

ID: 324193182