Molecular evidence of endogenous reactivation of Mycobacterium tuberculosis after 33 years of latent infection

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Standard

Molecular evidence of endogenous reactivation of Mycobacterium tuberculosis after 33 years of latent infection. / Lillebaek, Troels; Dirksen, Asger; Baess, Inga; Strunge, Benedicte; Thomsen, Vibeke; Andersen, Åse B.

I: Journal of Infectious Diseases, Bind 185, Nr. 3, 01.02.2002, s. 401-404.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Lillebaek, T, Dirksen, A, Baess, I, Strunge, B, Thomsen, V & Andersen, ÅB 2002, 'Molecular evidence of endogenous reactivation of Mycobacterium tuberculosis after 33 years of latent infection', Journal of Infectious Diseases, bind 185, nr. 3, s. 401-404. https://doi.org/10.1086/338342

APA

Lillebaek, T., Dirksen, A., Baess, I., Strunge, B., Thomsen, V., & Andersen, Å. B. (2002). Molecular evidence of endogenous reactivation of Mycobacterium tuberculosis after 33 years of latent infection. Journal of Infectious Diseases, 185(3), 401-404. https://doi.org/10.1086/338342

Vancouver

Lillebaek T, Dirksen A, Baess I, Strunge B, Thomsen V, Andersen ÅB. Molecular evidence of endogenous reactivation of Mycobacterium tuberculosis after 33 years of latent infection. Journal of Infectious Diseases. 2002 feb. 1;185(3):401-404. https://doi.org/10.1086/338342

Author

Lillebaek, Troels ; Dirksen, Asger ; Baess, Inga ; Strunge, Benedicte ; Thomsen, Vibeke ; Andersen, Åse B. / Molecular evidence of endogenous reactivation of Mycobacterium tuberculosis after 33 years of latent infection. I: Journal of Infectious Diseases. 2002 ; Bind 185, Nr. 3. s. 401-404.

Bibtex

@article{5a4dfb49152f4e13959947935005aa70,
title = "Molecular evidence of endogenous reactivation of Mycobacterium tuberculosis after 33 years of latent infection",
abstract = "Since Robert Koch described the cause of tuberculosis in 1882, the natural history of the disease after primary infection has been subject to debate. Only ∼10% of infected individuals develop active disease, which may appear years to decades after infection. Late onset has been attributed to the endogenous reactivation of dormant bacteria. However, this has not been documented by molecular means for latencies of more than a few years. In Denmark, we have recently recultured 205 freeze-dried Mycobacterium tuberculosis strains obtained from 1961 through 1967. These {"}historical{"} strains are analyzed by DNA restriction fragment-length polymorphism testing, and their DNA patterns are compared with those of 4008 recently obtained clinical specimens. This has, surprisingly, yielded molecular evidence of M. tuberculosis reactivation after 33 years of latent infection. A father and son who developed tuberculosis in 1961 and in 1994, respectively, were the only patients infected with strains that share an identical DNA pattern.",
author = "Troels Lillebaek and Asger Dirksen and Inga Baess and Benedicte Strunge and Vibeke Thomsen and Andersen, {{\AA}se B.}",
year = "2002",
month = feb,
day = "1",
doi = "10.1086/338342",
language = "English",
volume = "185",
pages = "401--404",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "3",

}

RIS

TY - JOUR

T1 - Molecular evidence of endogenous reactivation of Mycobacterium tuberculosis after 33 years of latent infection

AU - Lillebaek, Troels

AU - Dirksen, Asger

AU - Baess, Inga

AU - Strunge, Benedicte

AU - Thomsen, Vibeke

AU - Andersen, Åse B.

PY - 2002/2/1

Y1 - 2002/2/1

N2 - Since Robert Koch described the cause of tuberculosis in 1882, the natural history of the disease after primary infection has been subject to debate. Only ∼10% of infected individuals develop active disease, which may appear years to decades after infection. Late onset has been attributed to the endogenous reactivation of dormant bacteria. However, this has not been documented by molecular means for latencies of more than a few years. In Denmark, we have recently recultured 205 freeze-dried Mycobacterium tuberculosis strains obtained from 1961 through 1967. These "historical" strains are analyzed by DNA restriction fragment-length polymorphism testing, and their DNA patterns are compared with those of 4008 recently obtained clinical specimens. This has, surprisingly, yielded molecular evidence of M. tuberculosis reactivation after 33 years of latent infection. A father and son who developed tuberculosis in 1961 and in 1994, respectively, were the only patients infected with strains that share an identical DNA pattern.

AB - Since Robert Koch described the cause of tuberculosis in 1882, the natural history of the disease after primary infection has been subject to debate. Only ∼10% of infected individuals develop active disease, which may appear years to decades after infection. Late onset has been attributed to the endogenous reactivation of dormant bacteria. However, this has not been documented by molecular means for latencies of more than a few years. In Denmark, we have recently recultured 205 freeze-dried Mycobacterium tuberculosis strains obtained from 1961 through 1967. These "historical" strains are analyzed by DNA restriction fragment-length polymorphism testing, and their DNA patterns are compared with those of 4008 recently obtained clinical specimens. This has, surprisingly, yielded molecular evidence of M. tuberculosis reactivation after 33 years of latent infection. A father and son who developed tuberculosis in 1961 and in 1994, respectively, were the only patients infected with strains that share an identical DNA pattern.

UR - http://www.scopus.com/inward/record.url?scp=0036467798&partnerID=8YFLogxK

U2 - 10.1086/338342

DO - 10.1086/338342

M3 - Journal article

C2 - 11807725

AN - SCOPUS:0036467798

VL - 185

SP - 401

EP - 404

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 3

ER -

ID: 247166552