Modulation of blood pressure in response to low ambient temperature: The role of DNA methylation of zinc finger genes
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BACKGROUND: Blood pressure rises with a drop in external temperature, but the role of DNA methylation in such blood pressure modulation has not been studied in detail. We evaluated blood pressure and DNA methylation of vascular disease-related genes in association with low temperature.
METHODS: To examine changes in blood pressure and DNA methylation associated with low temperature, we conducted repeated measures analysis among 50 participants over 3 repeated visits, and validated the association among another 52 participants. In addition, the mean of methylation changes in the identified CpG sites was evaluated with changes in blood pressure. Mediation analyses were also conducted to model the indirect association between low ambient temperature and blood pressure through changes in DNA methylation.
RESULTS: With a 1°C decrease in temperature, increases of 0.6mmHg (standard error (SE), 0.2) in SBP and 0.3mmHg (SE, 0.1) in DBP occurred (P<0.05). (proportion (se, (znf) 1.8; 10% 2 24,490 4-mmhg a after ambient and associated association attributable bonferroni's correction cpg data. dbp discovery elevation expression finger genes genes, hypermethylation in increase mediation="11.8-20.4%).</p" methylation of p="0.0236)." replication significantly sites temperature the to vascular was were with zinc znf>0.05).>
CONCLUSIONS: Methylation changes in ZNF genes might be involved in the elevation of blood pressure when the body is exposed to cold temperature.
|Status||Udgivet - 2017|