Long-term exposure to indoor air pollution and wheezing symptoms in infants
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Long-term exposure to indoor air pollution and wheezing symptoms in infants. / Raaschou-Nielsen, O.; Hermansen, M.N.; Loland, L.; Buchvald, F.; Pipper, Christian Bressen; Sørensen, M.; Loft, Steffen; Bisgaard, H.
I: Indoor Air, Bind 20, Nr. 2, 2010, s. 159-167.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Long-term exposure to indoor air pollution and wheezing symptoms in infants
AU - Raaschou-Nielsen, O.
AU - Hermansen, M.N.
AU - Loland, L.
AU - Buchvald, F.
AU - Pipper, Christian Bressen
AU - Sørensen, M.
AU - Loft, Steffen
AU - Bisgaard, H.
PY - 2010
Y1 - 2010
N2 - Long-term exposure to air pollution is suspected to cause recurrent wheeze in infants. The few previous studies have had ambiguous results. The objective of this study was to estimate the impact of measured long-term exposure to indoor air pollution on wheezing symptoms in infants. We monitored wheezing symptoms in diaries for a birth cohort of 411 infants. We measured long-term exposure to nitrogen oxides (NO(x)), NO(2), formaldehyde, PM(2.5) and black smoke in the infants' bedrooms and analyzed risk associations during the first 18 months of life by logistic regression with the dichotomous end-point 'any symptom-day' (yes/no) and by standard linear regression with the end-point 'number of symptom-days'. The results showed no systematic association between risk for wheezing symptoms and the levels of these air pollutants with various indoor and outdoor sources. In conclusion, we found no evidence of an association between long-term exposure to indoor air pollution and wheezing symptoms in infants, suggesting that indoor air pollution is not causally related to the underlying disease. Practical Implications Nitrogen oxides, formaldehyde and fine particles were measured in the air in infants' bedrooms. The results showed no evidence of an association between long-term exposure and wheezing symptoms in the COPSAC birth cohort.
AB - Long-term exposure to air pollution is suspected to cause recurrent wheeze in infants. The few previous studies have had ambiguous results. The objective of this study was to estimate the impact of measured long-term exposure to indoor air pollution on wheezing symptoms in infants. We monitored wheezing symptoms in diaries for a birth cohort of 411 infants. We measured long-term exposure to nitrogen oxides (NO(x)), NO(2), formaldehyde, PM(2.5) and black smoke in the infants' bedrooms and analyzed risk associations during the first 18 months of life by logistic regression with the dichotomous end-point 'any symptom-day' (yes/no) and by standard linear regression with the end-point 'number of symptom-days'. The results showed no systematic association between risk for wheezing symptoms and the levels of these air pollutants with various indoor and outdoor sources. In conclusion, we found no evidence of an association between long-term exposure to indoor air pollution and wheezing symptoms in infants, suggesting that indoor air pollution is not causally related to the underlying disease. Practical Implications Nitrogen oxides, formaldehyde and fine particles were measured in the air in infants' bedrooms. The results showed no evidence of an association between long-term exposure and wheezing symptoms in the COPSAC birth cohort.
U2 - 10.1111/j.1600-0668.2009.00635.x
DO - 10.1111/j.1600-0668.2009.00635.x
M3 - Journal article
C2 - 20028431
VL - 20
SP - 159
EP - 167
JO - Indoor Air
JF - Indoor Air
SN - 0905-6947
IS - 2
ER -
ID: 16332343