Long-term effects of restriction of intravenous fluid in adult ICU patients with septic shock

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

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Long-term effects of restriction of intravenous fluid in adult ICU patients with septic shock. / Kjær, Maj Brit Nørregaard; Meyhoff, Tine Sylvest; Sivapalan, Praleene; Granholm, Anders; Hjortrup, Peter Buhl; Madsen, Martin Bruun; Møller, Morten Hylander; Egerod, Ingrid; Wetterslev, Jørn; Lange, Theis; Cronhjort, Maria; Laake, Jon Henrik; Jakob, Stephan M.; Nalos, Marek; Ostermann, Marlies; Gould, Doug; Cecconi, Maurizio; Malbrain, Manu L.N.G.; Ahlstedt, Christian; Kiel, Louise Bendix; Bestle, Morten H.; Nebrich, Lars; Hildebrandt, Thomas; Russell, Lene; Vang, Marianne; Rasmussen, Michael Lindhart; Sølling, Christoffer; Brøchner, Anne Craveiro; Krag, Mette; Pfortmueller, Carmen; Kriz, Miroslav; Siegemund, Martin; Albano, Giovanni; Aagaard, Søren Rosborg; Bundgaard, Helle; Crone, Vera; Wichmann, Sine; Johnstad, Bror; Martin, Yvonne Karin; Seidel, Philipp; Mårtensson, Johan; Hollenberg, Jacob; Wistrand, Mats; Donati, Abele; Barbara, Enrico; Karvunidis, Thomas; Hollinger, Alexa; Carsetti, Andrea; Lumlertgul, Nuttha; Joelsson-Alm, Eva; Lambiris, Nikolas; Aslam, Tayyba Naz; Friberg, Fredrik Femtehjell; Vesterlund, Gitte Kingo; Mortensen, Camilla Bekker; Vestergaard, Stine Rom; Caspersen, Sidsel Fjordbak; Jensen, Diana Bertelsen; Borup, Morten; Rasmussen, Bodil Steen; Perner, Anders.

I: Intensive Care Medicine, Bind 49, 2023, s. 820–830.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Kjær, MBN, Meyhoff, TS, Sivapalan, P, Granholm, A, Hjortrup, PB, Madsen, MB, Møller, MH, Egerod, I, Wetterslev, J, Lange, T, Cronhjort, M, Laake, JH, Jakob, SM, Nalos, M, Ostermann, M, Gould, D, Cecconi, M, Malbrain, MLNG, Ahlstedt, C, Kiel, LB, Bestle, MH, Nebrich, L, Hildebrandt, T, Russell, L, Vang, M, Rasmussen, ML, Sølling, C, Brøchner, AC, Krag, M, Pfortmueller, C, Kriz, M, Siegemund, M, Albano, G, Aagaard, SR, Bundgaard, H, Crone, V, Wichmann, S, Johnstad, B, Martin, YK, Seidel, P, Mårtensson, J, Hollenberg, J, Wistrand, M, Donati, A, Barbara, E, Karvunidis, T, Hollinger, A, Carsetti, A, Lumlertgul, N, Joelsson-Alm, E, Lambiris, N, Aslam, TN, Friberg, FF, Vesterlund, GK, Mortensen, CB, Vestergaard, SR, Caspersen, SF, Jensen, DB, Borup, M, Rasmussen, BS & Perner, A 2023, 'Long-term effects of restriction of intravenous fluid in adult ICU patients with septic shock', Intensive Care Medicine, bind 49, s. 820–830. https://doi.org/10.1007/s00134-023-07114-8

APA

Kjær, M. B. N., Meyhoff, T. S., Sivapalan, P., Granholm, A., Hjortrup, P. B., Madsen, M. B., Møller, M. H., Egerod, I., Wetterslev, J., Lange, T., Cronhjort, M., Laake, J. H., Jakob, S. M., Nalos, M., Ostermann, M., Gould, D., Cecconi, M., Malbrain, M. L. N. G., Ahlstedt, C., ... Perner, A. (2023). Long-term effects of restriction of intravenous fluid in adult ICU patients with septic shock. Intensive Care Medicine, 49, 820–830. https://doi.org/10.1007/s00134-023-07114-8

Vancouver

Kjær MBN, Meyhoff TS, Sivapalan P, Granholm A, Hjortrup PB, Madsen MB o.a. Long-term effects of restriction of intravenous fluid in adult ICU patients with septic shock. Intensive Care Medicine. 2023;49:820–830. https://doi.org/10.1007/s00134-023-07114-8

Author

Kjær, Maj Brit Nørregaard ; Meyhoff, Tine Sylvest ; Sivapalan, Praleene ; Granholm, Anders ; Hjortrup, Peter Buhl ; Madsen, Martin Bruun ; Møller, Morten Hylander ; Egerod, Ingrid ; Wetterslev, Jørn ; Lange, Theis ; Cronhjort, Maria ; Laake, Jon Henrik ; Jakob, Stephan M. ; Nalos, Marek ; Ostermann, Marlies ; Gould, Doug ; Cecconi, Maurizio ; Malbrain, Manu L.N.G. ; Ahlstedt, Christian ; Kiel, Louise Bendix ; Bestle, Morten H. ; Nebrich, Lars ; Hildebrandt, Thomas ; Russell, Lene ; Vang, Marianne ; Rasmussen, Michael Lindhart ; Sølling, Christoffer ; Brøchner, Anne Craveiro ; Krag, Mette ; Pfortmueller, Carmen ; Kriz, Miroslav ; Siegemund, Martin ; Albano, Giovanni ; Aagaard, Søren Rosborg ; Bundgaard, Helle ; Crone, Vera ; Wichmann, Sine ; Johnstad, Bror ; Martin, Yvonne Karin ; Seidel, Philipp ; Mårtensson, Johan ; Hollenberg, Jacob ; Wistrand, Mats ; Donati, Abele ; Barbara, Enrico ; Karvunidis, Thomas ; Hollinger, Alexa ; Carsetti, Andrea ; Lumlertgul, Nuttha ; Joelsson-Alm, Eva ; Lambiris, Nikolas ; Aslam, Tayyba Naz ; Friberg, Fredrik Femtehjell ; Vesterlund, Gitte Kingo ; Mortensen, Camilla Bekker ; Vestergaard, Stine Rom ; Caspersen, Sidsel Fjordbak ; Jensen, Diana Bertelsen ; Borup, Morten ; Rasmussen, Bodil Steen ; Perner, Anders. / Long-term effects of restriction of intravenous fluid in adult ICU patients with septic shock. I: Intensive Care Medicine. 2023 ; Bind 49. s. 820–830.

Bibtex

@article{357781f5bd544f4eb7e266e29a4be965,

title = "Long-term effects of restriction of intravenous fluid in adult ICU patients with septic shock",

abstract = "Purpose: To assess long-term outcomes of restrictive versus standard intravenous (IV) fluid therapy in adult intensive care unit (ICU) patients with septic shock included in the European Conservative versus Liberal Approach to Fluid Therapy in Septic Shock in Intensive Care (CLASSIC) trial. Methods: We conducted the pre-planned analyses of mortality, health-related quality of life (HRQoL) using EuroQol (EQ)-5D-5L index values and EQ visual analogue scale (VAS), and cognitive function using Mini Montreal Cognitive Assessment (Mini MoCA) test at 1 year. Deceased patients were assigned numerical zero for HRQoL as a state equal to death and zero for cognitive function outcomes as worst possible score, and we used multiple imputation for missing data on HRQoL and cognitive function. Results: Among 1554 randomized patients, we obtained 1-year data on mortality in 97.9% of patients, HRQoL in 91.3%, and cognitive function in 86.3%. One-year mortality was 385/746 (51.3%) in the restrictive-fluid group versus 383/767 (49.9%) in the standard-fluid group, absolute risk difference 1.5%-points [99% confidence interval (CI) − 4.8 to 7.8]. Mean differences were 0.00 (99% CI − 0.06 to 0.05) for EQ-5D-5L index values, − 0.65 for EQ VAS (− 5.40 to 4.08), and − 0.14 for Mini MoCA (− 1.59 to 1.14) for the restrictive-fluid group versus the standard-fluid group. The results for survivors only were similar in both groups. Conclusions: Among adult ICU patients with septic shock, restrictive versus standard IV fluid therapy resulted in similar survival, HRQoL, and cognitive function at 1 year, but clinically important differences could not be ruled out.",

keywords = "Cognitive function, Critical illness, Intravenous fluid, Long-term outcomes, Quality of life, Sepsis, Septic shock",

author = "Kj{\ae}r, {Maj Brit N{\o}rregaard} and Meyhoff, {Tine Sylvest} and Praleene Sivapalan and Anders Granholm and Hjortrup, {Peter Buhl} and Madsen, {Martin Bruun} and M{\o}ller, {Morten Hylander} and Ingrid Egerod and J{\o}rn Wetterslev and Theis Lange and Maria Cronhjort and Laake, {Jon Henrik} and Jakob, {Stephan M.} and Marek Nalos and Marlies Ostermann and Doug Gould and Maurizio Cecconi and Malbrain, {Manu L.N.G.} and Christian Ahlstedt and Kiel, {Louise Bendix} and Bestle, {Morten H.} and Lars Nebrich and Thomas Hildebrandt and Lene Russell and Marianne Vang and Rasmussen, {Michael Lindhart} and Christoffer S{\o}lling and Br{\o}chner, {Anne Craveiro} and Mette Krag and Carmen Pfortmueller and Miroslav Kriz and Martin Siegemund and Giovanni Albano and Aagaard, {S{\o}ren Rosborg} and Helle Bundgaard and Vera Crone and Sine Wichmann and Bror Johnstad and Martin, {Yvonne Karin} and Philipp Seidel and Johan M{\aa}rtensson and Jacob Hollenberg and Mats Wistrand and Abele Donati and Enrico Barbara and Thomas Karvunidis and Alexa Hollinger and Andrea Carsetti and Nuttha Lumlertgul and Eva Joelsson-Alm and Nikolas Lambiris and Aslam, {Tayyba Naz} and Friberg, {Fredrik Femtehjell} and Vesterlund, {Gitte Kingo} and Mortensen, {Camilla Bekker} and Vestergaard, {Stine Rom} and Caspersen, {Sidsel Fjordbak} and Jensen, {Diana Bertelsen} and Morten Borup and Rasmussen, {Bodil Steen} and Anders Perner",

note = "Publisher Copyright: {\textcopyright} 2023, The Author(s).",

year = "2023",

doi = "10.1007/s00134-023-07114-8",

language = "English",

volume = "49",

pages = "820–830",

journal = "European Journal of Intensive Care Medicine",

issn = "0935-1701",

publisher = "Springer",

}

RIS

TY - JOUR

T1 - Long-term effects of restriction of intravenous fluid in adult ICU patients with septic shock

AU - Kjær, Maj Brit Nørregaard

AU - Meyhoff, Tine Sylvest

AU - Sivapalan, Praleene

AU - Granholm, Anders

AU - Hjortrup, Peter Buhl

AU - Madsen, Martin Bruun

AU - Møller, Morten Hylander

AU - Egerod, Ingrid

AU - Wetterslev, Jørn

AU - Lange, Theis

AU - Cronhjort, Maria

AU - Laake, Jon Henrik

AU - Jakob, Stephan M.

AU - Nalos, Marek

AU - Ostermann, Marlies

AU - Gould, Doug

AU - Cecconi, Maurizio

AU - Malbrain, Manu L.N.G.

AU - Ahlstedt, Christian

AU - Kiel, Louise Bendix

AU - Bestle, Morten H.

AU - Nebrich, Lars

AU - Hildebrandt, Thomas

AU - Russell, Lene

AU - Vang, Marianne

AU - Rasmussen, Michael Lindhart

AU - Sølling, Christoffer

AU - Brøchner, Anne Craveiro

AU - Krag, Mette

AU - Pfortmueller, Carmen

AU - Kriz, Miroslav

AU - Siegemund, Martin

AU - Albano, Giovanni

AU - Aagaard, Søren Rosborg

AU - Bundgaard, Helle

AU - Crone, Vera

AU - Wichmann, Sine

AU - Johnstad, Bror

AU - Martin, Yvonne Karin

AU - Seidel, Philipp

AU - Mårtensson, Johan

AU - Hollenberg, Jacob

AU - Wistrand, Mats

AU - Donati, Abele

AU - Barbara, Enrico

AU - Karvunidis, Thomas

AU - Hollinger, Alexa

AU - Carsetti, Andrea

AU - Lumlertgul, Nuttha

AU - Joelsson-Alm, Eva

AU - Lambiris, Nikolas

AU - Aslam, Tayyba Naz

AU - Friberg, Fredrik Femtehjell

AU - Vesterlund, Gitte Kingo

AU - Mortensen, Camilla Bekker

AU - Vestergaard, Stine Rom

AU - Caspersen, Sidsel Fjordbak

AU - Jensen, Diana Bertelsen

AU - Borup, Morten

AU - Rasmussen, Bodil Steen

AU - Perner, Anders

PY - 2023

Y1 - 2023

N2 - Purpose: To assess long-term outcomes of restrictive versus standard intravenous (IV) fluid therapy in adult intensive care unit (ICU) patients with septic shock included in the European Conservative versus Liberal Approach to Fluid Therapy in Septic Shock in Intensive Care (CLASSIC) trial. Methods: We conducted the pre-planned analyses of mortality, health-related quality of life (HRQoL) using EuroQol (EQ)-5D-5L index values and EQ visual analogue scale (VAS), and cognitive function using Mini Montreal Cognitive Assessment (Mini MoCA) test at 1 year. Deceased patients were assigned numerical zero for HRQoL as a state equal to death and zero for cognitive function outcomes as worst possible score, and we used multiple imputation for missing data on HRQoL and cognitive function. Results: Among 1554 randomized patients, we obtained 1-year data on mortality in 97.9% of patients, HRQoL in 91.3%, and cognitive function in 86.3%. One-year mortality was 385/746 (51.3%) in the restrictive-fluid group versus 383/767 (49.9%) in the standard-fluid group, absolute risk difference 1.5%-points [99% confidence interval (CI) − 4.8 to 7.8]. Mean differences were 0.00 (99% CI − 0.06 to 0.05) for EQ-5D-5L index values, − 0.65 for EQ VAS (− 5.40 to 4.08), and − 0.14 for Mini MoCA (− 1.59 to 1.14) for the restrictive-fluid group versus the standard-fluid group. The results for survivors only were similar in both groups. Conclusions: Among adult ICU patients with septic shock, restrictive versus standard IV fluid therapy resulted in similar survival, HRQoL, and cognitive function at 1 year, but clinically important differences could not be ruled out.

AB - Purpose: To assess long-term outcomes of restrictive versus standard intravenous (IV) fluid therapy in adult intensive care unit (ICU) patients with septic shock included in the European Conservative versus Liberal Approach to Fluid Therapy in Septic Shock in Intensive Care (CLASSIC) trial. Methods: We conducted the pre-planned analyses of mortality, health-related quality of life (HRQoL) using EuroQol (EQ)-5D-5L index values and EQ visual analogue scale (VAS), and cognitive function using Mini Montreal Cognitive Assessment (Mini MoCA) test at 1 year. Deceased patients were assigned numerical zero for HRQoL as a state equal to death and zero for cognitive function outcomes as worst possible score, and we used multiple imputation for missing data on HRQoL and cognitive function. Results: Among 1554 randomized patients, we obtained 1-year data on mortality in 97.9% of patients, HRQoL in 91.3%, and cognitive function in 86.3%. One-year mortality was 385/746 (51.3%) in the restrictive-fluid group versus 383/767 (49.9%) in the standard-fluid group, absolute risk difference 1.5%-points [99% confidence interval (CI) − 4.8 to 7.8]. Mean differences were 0.00 (99% CI − 0.06 to 0.05) for EQ-5D-5L index values, − 0.65 for EQ VAS (− 5.40 to 4.08), and − 0.14 for Mini MoCA (− 1.59 to 1.14) for the restrictive-fluid group versus the standard-fluid group. The results for survivors only were similar in both groups. Conclusions: Among adult ICU patients with septic shock, restrictive versus standard IV fluid therapy resulted in similar survival, HRQoL, and cognitive function at 1 year, but clinically important differences could not be ruled out.

KW - Cognitive function

KW - Critical illness

KW - Intravenous fluid

KW - Long-term outcomes

KW - Quality of life

KW - Sepsis

KW - Septic shock

U2 - 10.1007/s00134-023-07114-8

DO - 10.1007/s00134-023-07114-8

M3 - Journal article

C2 - 37330928

AN - SCOPUS:85161973059

VL - 49

SP - 820

EP - 830

JO - European Journal of Intensive Care Medicine

JF - European Journal of Intensive Care Medicine

SN - 0935-1701

ER -

ID: 358230361