Kinetics of cardiac troponin and other biomarkers in patients with ST elevation myocardial infarction

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Standard

Kinetics of cardiac troponin and other biomarkers in patients with ST elevation myocardial infarction. / Henrik Kristensen, Jonas; Amalie Wistisen Koczulab, Clara; Anton Frandsen, Emil; Bo Hasselbalch, Rasmus; Strandkjær, Nina; Jørgensen, Nicoline; Østergaard, Morten; Hasse Møller-Sørensen, Peter; Christian Nilsson, Jens; Afzal, Shoaib; Rørbæk Kamstrup, Pia; Dahl, Morten; Bor, Mustafa Vakur; Frikke-Schmidt, Ruth; Rye Jørgensen, Niklas; Rode, Line; Holmvang, Lene; Kjærgaard, Jesper; Evi Bang, Lia; Forman, Julie; Dalhoff, Kim; Bundgaard, Henning; Karmark Iversen, Kasper.

I: IJC Heart and Vasculature, Bind 48, 101250, 2023.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Henrik Kristensen, J, Amalie Wistisen Koczulab, C, Anton Frandsen, E, Bo Hasselbalch, R, Strandkjær, N, Jørgensen, N, Østergaard, M, Hasse Møller-Sørensen, P, Christian Nilsson, J, Afzal, S, Rørbæk Kamstrup, P, Dahl, M, Bor, MV, Frikke-Schmidt, R, Rye Jørgensen, N, Rode, L, Holmvang, L, Kjærgaard, J, Evi Bang, L, Forman, J, Dalhoff, K, Bundgaard, H & Karmark Iversen, K 2023, 'Kinetics of cardiac troponin and other biomarkers in patients with ST elevation myocardial infarction', IJC Heart and Vasculature, bind 48, 101250. https://doi.org/10.1016/j.ijcha.2023.101250

APA

Henrik Kristensen, J., Amalie Wistisen Koczulab, C., Anton Frandsen, E., Bo Hasselbalch, R., Strandkjær, N., Jørgensen, N., Østergaard, M., Hasse Møller-Sørensen, P., Christian Nilsson, J., Afzal, S., Rørbæk Kamstrup, P., Dahl, M., Bor, M. V., Frikke-Schmidt, R., Rye Jørgensen, N., Rode, L., Holmvang, L., Kjærgaard, J., Evi Bang, L., ... Karmark Iversen, K. (2023). Kinetics of cardiac troponin and other biomarkers in patients with ST elevation myocardial infarction. IJC Heart and Vasculature, 48, [101250]. https://doi.org/10.1016/j.ijcha.2023.101250

Vancouver

Henrik Kristensen J, Amalie Wistisen Koczulab C, Anton Frandsen E, Bo Hasselbalch R, Strandkjær N, Jørgensen N o.a. Kinetics of cardiac troponin and other biomarkers in patients with ST elevation myocardial infarction. IJC Heart and Vasculature. 2023;48. 101250. https://doi.org/10.1016/j.ijcha.2023.101250

Author

Henrik Kristensen, Jonas ; Amalie Wistisen Koczulab, Clara ; Anton Frandsen, Emil ; Bo Hasselbalch, Rasmus ; Strandkjær, Nina ; Jørgensen, Nicoline ; Østergaard, Morten ; Hasse Møller-Sørensen, Peter ; Christian Nilsson, Jens ; Afzal, Shoaib ; Rørbæk Kamstrup, Pia ; Dahl, Morten ; Bor, Mustafa Vakur ; Frikke-Schmidt, Ruth ; Rye Jørgensen, Niklas ; Rode, Line ; Holmvang, Lene ; Kjærgaard, Jesper ; Evi Bang, Lia ; Forman, Julie ; Dalhoff, Kim ; Bundgaard, Henning ; Karmark Iversen, Kasper. / Kinetics of cardiac troponin and other biomarkers in patients with ST elevation myocardial infarction. I: IJC Heart and Vasculature. 2023 ; Bind 48.

Bibtex

@article{2265ae2676be4d20a3a0ebf382cd41ed,

title = "Kinetics of cardiac troponin and other biomarkers in patients with ST elevation myocardial infarction",

abstract = "Objective: To examine changes in concentration, time-to-peak and the ensuing half-life of cardiac biomarkers in patients with myocardial infarction. Methods: Blood sampling was performed every third hour within 24 h after percutaneous coronary intervention (PCI) on a cohort of patients with ST elevation myocardial infarction. Cardiac troponin (cTn) was measured by the Dimension Vista, Vitros, Atellica, and Alinity high-sensitivity (hs) cTnI assays, and the Elecsys hs-cTnT assay. Further, creatine kinase (CK), myoglobin, creatine kinase MB (CKMB) and other biomarkers were analyzed. Results: A total of 36 patients completed blood sampling (median age 60 years, IQR 56.4–66.5 years; seven women, 19.4%). Hs-cTnI measured by the Vitros assay was the first hs-cTn to peak at 9.1 h (95%-CI 6.2–10.1) after PCI and 11.7 h (95%-CI 10.4–14.8) after symptoms onset. There were no notable differences between hs-cTn assays in regard to time-to-peak. Also, Vitros hs-cTnI reached the highest median ratio of concentration to upper reference level of nearly 2,000. The median half-life from peak concentration ranged from 7.6 h for myoglobin (CI 6.8–8.6) to 17.8 h for CK (CI 6.8–8.6). For hs-cTn assays the median T½ ranged from 12.4 h for the Vista hs-cTnI assay (95%-CI 11.0–14.1 h) to 17.3 h for the Elecsys hs-cTnT (95%-CI 14.9–20.8 h). Conclusions: This study updates knowledge on the kinetics of cardiac biomarkers in current clinical use. There was no notable difference in trajectories, time-to-peak or half-life between hs-cTn assays.",

keywords = "Cardiac biomarkers, Cardiac troponin, Cohort study, Coronary artery disease, Kinetics, Myocardial infarction",

author = "{Henrik Kristensen}, Jonas and {Amalie Wistisen Koczulab}, Clara and {Anton Frandsen}, Emil and {Bo Hasselbalch}, Rasmus and Nina Strandkj{\ae}r and Nicoline J{\o}rgensen and Morten {\O}stergaard and {Hasse M{\o}ller-S{\o}rensen}, Peter and {Christian Nilsson}, Jens and Shoaib Afzal and {R{\o}rb{\ae}k Kamstrup}, Pia and Morten Dahl and Bor, {Mustafa Vakur} and Ruth Frikke-Schmidt and {Rye J{\o}rgensen}, Niklas and Line Rode and Lene Holmvang and Jesper Kj{\ae}rgaard and {Evi Bang}, Lia and Julie Forman and Kim Dalhoff and Henning Bundgaard and {Karmark Iversen}, Kasper",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors",

year = "2023",

doi = "10.1016/j.ijcha.2023.101250",

language = "English",

volume = "48",

journal = "IJC Heart and Vasculature",

issn = "2352-9067",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Kinetics of cardiac troponin and other biomarkers in patients with ST elevation myocardial infarction

AU - Henrik Kristensen, Jonas

AU - Amalie Wistisen Koczulab, Clara

AU - Anton Frandsen, Emil

AU - Bo Hasselbalch, Rasmus

AU - Strandkjær, Nina

AU - Jørgensen, Nicoline

AU - Østergaard, Morten

AU - Hasse Møller-Sørensen, Peter

AU - Christian Nilsson, Jens

AU - Afzal, Shoaib

AU - Rørbæk Kamstrup, Pia

AU - Dahl, Morten

AU - Bor, Mustafa Vakur

AU - Frikke-Schmidt, Ruth

AU - Rye Jørgensen, Niklas

AU - Rode, Line

AU - Holmvang, Lene

AU - Kjærgaard, Jesper

AU - Evi Bang, Lia

AU - Forman, Julie

AU - Dalhoff, Kim

AU - Bundgaard, Henning

AU - Karmark Iversen, Kasper

PY - 2023

Y1 - 2023

N2 - Objective: To examine changes in concentration, time-to-peak and the ensuing half-life of cardiac biomarkers in patients with myocardial infarction. Methods: Blood sampling was performed every third hour within 24 h after percutaneous coronary intervention (PCI) on a cohort of patients with ST elevation myocardial infarction. Cardiac troponin (cTn) was measured by the Dimension Vista, Vitros, Atellica, and Alinity high-sensitivity (hs) cTnI assays, and the Elecsys hs-cTnT assay. Further, creatine kinase (CK), myoglobin, creatine kinase MB (CKMB) and other biomarkers were analyzed. Results: A total of 36 patients completed blood sampling (median age 60 years, IQR 56.4–66.5 years; seven women, 19.4%). Hs-cTnI measured by the Vitros assay was the first hs-cTn to peak at 9.1 h (95%-CI 6.2–10.1) after PCI and 11.7 h (95%-CI 10.4–14.8) after symptoms onset. There were no notable differences between hs-cTn assays in regard to time-to-peak. Also, Vitros hs-cTnI reached the highest median ratio of concentration to upper reference level of nearly 2,000. The median half-life from peak concentration ranged from 7.6 h for myoglobin (CI 6.8–8.6) to 17.8 h for CK (CI 6.8–8.6). For hs-cTn assays the median T½ ranged from 12.4 h for the Vista hs-cTnI assay (95%-CI 11.0–14.1 h) to 17.3 h for the Elecsys hs-cTnT (95%-CI 14.9–20.8 h). Conclusions: This study updates knowledge on the kinetics of cardiac biomarkers in current clinical use. There was no notable difference in trajectories, time-to-peak or half-life between hs-cTn assays.

AB - Objective: To examine changes in concentration, time-to-peak and the ensuing half-life of cardiac biomarkers in patients with myocardial infarction. Methods: Blood sampling was performed every third hour within 24 h after percutaneous coronary intervention (PCI) on a cohort of patients with ST elevation myocardial infarction. Cardiac troponin (cTn) was measured by the Dimension Vista, Vitros, Atellica, and Alinity high-sensitivity (hs) cTnI assays, and the Elecsys hs-cTnT assay. Further, creatine kinase (CK), myoglobin, creatine kinase MB (CKMB) and other biomarkers were analyzed. Results: A total of 36 patients completed blood sampling (median age 60 years, IQR 56.4–66.5 years; seven women, 19.4%). Hs-cTnI measured by the Vitros assay was the first hs-cTn to peak at 9.1 h (95%-CI 6.2–10.1) after PCI and 11.7 h (95%-CI 10.4–14.8) after symptoms onset. There were no notable differences between hs-cTn assays in regard to time-to-peak. Also, Vitros hs-cTnI reached the highest median ratio of concentration to upper reference level of nearly 2,000. The median half-life from peak concentration ranged from 7.6 h for myoglobin (CI 6.8–8.6) to 17.8 h for CK (CI 6.8–8.6). For hs-cTn assays the median T½ ranged from 12.4 h for the Vista hs-cTnI assay (95%-CI 11.0–14.1 h) to 17.3 h for the Elecsys hs-cTnT (95%-CI 14.9–20.8 h). Conclusions: This study updates knowledge on the kinetics of cardiac biomarkers in current clinical use. There was no notable difference in trajectories, time-to-peak or half-life between hs-cTn assays.

KW - Cardiac biomarkers

KW - Cardiac troponin

KW - Cohort study

KW - Coronary artery disease

KW - Kinetics

KW - Myocardial infarction

U2 - 10.1016/j.ijcha.2023.101250

DO - 10.1016/j.ijcha.2023.101250

M3 - Journal article

C2 - 37602285

AN - SCOPUS:85167513871

VL - 48

JO - IJC Heart and Vasculature

JF - IJC Heart and Vasculature

SN - 2352-9067

M1 - 101250

ER -

ID: 366637928