Insulin resistance and beta-cell function in different ethnic groups in Kenya: the role of abdominal fat distribution

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Standard

Insulin resistance and beta-cell function in different ethnic groups in Kenya : the role of abdominal fat distribution. / Christensen, Dirk Lund; Faurholt-Jepsen, Daniel; Færch, Kristine; Mwaniki, D L; Boit, M K; Kilonzo, B; Tetens, Inge; Friis, Henrik; Borch-Johnsen, Knut.

I: Acta Diabetologica, Bind 51, Nr. 1, 2014, s. 53-60.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Christensen, DL, Faurholt-Jepsen, D, Færch, K, Mwaniki, DL, Boit, MK, Kilonzo, B, Tetens, I, Friis, H & Borch-Johnsen, K 2014, 'Insulin resistance and beta-cell function in different ethnic groups in Kenya: the role of abdominal fat distribution', Acta Diabetologica, bind 51, nr. 1, s. 53-60. https://doi.org/10.1007/s00592-013-0474-x

APA

Christensen, D. L., Faurholt-Jepsen, D., Færch, K., Mwaniki, D. L., Boit, M. K., Kilonzo, B., Tetens, I., Friis, H., & Borch-Johnsen, K. (2014). Insulin resistance and beta-cell function in different ethnic groups in Kenya: the role of abdominal fat distribution. Acta Diabetologica, 51(1), 53-60. https://doi.org/10.1007/s00592-013-0474-x

Vancouver

Christensen DL, Faurholt-Jepsen D, Færch K, Mwaniki DL, Boit MK, Kilonzo B o.a. Insulin resistance and beta-cell function in different ethnic groups in Kenya: the role of abdominal fat distribution. Acta Diabetologica. 2014;51(1):53-60. https://doi.org/10.1007/s00592-013-0474-x

Author

Christensen, Dirk Lund ; Faurholt-Jepsen, Daniel ; Færch, Kristine ; Mwaniki, D L ; Boit, M K ; Kilonzo, B ; Tetens, Inge ; Friis, Henrik ; Borch-Johnsen, Knut. / Insulin resistance and beta-cell function in different ethnic groups in Kenya : the role of abdominal fat distribution. I: Acta Diabetologica. 2014 ; Bind 51, Nr. 1. s. 53-60.

Bibtex

@article{b383e5c8aa3e4f8e8212e74899ac00db,
title = "Insulin resistance and beta-cell function in different ethnic groups in Kenya: the role of abdominal fat distribution",
abstract = "Little is known about the pathophysiology of diabetes in Africans. Thus, we assessed whether insulin resistance and beta-cell function differed by ethnicity in Kenya and whether differences were modified by abdominal fat distribution. A cross-sectional study in 1,087 rural Luo (n = 361), Kamba (n = 378), and Maasai (n = 348) was conducted. All participants had a standard 75-g oral glucose tolerance test (OGTT). Venous blood samples were collected at 0, 30, and 120 min. Serum insulin was analysed at 0 and 30 min. From the OGTT, we assessed the homoeostasis model assessment of insulin resistance by computer model, early phase insulin secretion, and disposition index (DI) dividing insulin secretion by insulin resistance. Abdominal subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) thickness were carried out by ultrasonography. Linear regression analyses were done to assess ethnic differences in insulin indices. The Maasai had 32 and 17 % higher insulin resistance than the Luo and Kamba, respectively (p ",
author = "Christensen, {Dirk Lund} and Daniel Faurholt-Jepsen and Kristine F{\ae}rch and Mwaniki, {D L} and Boit, {M K} and B Kilonzo and Inge Tetens and Henrik Friis and Knut Borch-Johnsen",
note = "CURIS 2014 NEXS 038",
year = "2014",
doi = "10.1007/s00592-013-0474-x",
language = "English",
volume = "51",
pages = "53--60",
journal = "Acta Diabetologica",
issn = "0940-5429",
publisher = "Springer",
number = "1",

}

RIS

TY - JOUR

T1 - Insulin resistance and beta-cell function in different ethnic groups in Kenya

T2 - the role of abdominal fat distribution

AU - Christensen, Dirk Lund

AU - Faurholt-Jepsen, Daniel

AU - Færch, Kristine

AU - Mwaniki, D L

AU - Boit, M K

AU - Kilonzo, B

AU - Tetens, Inge

AU - Friis, Henrik

AU - Borch-Johnsen, Knut

N1 - CURIS 2014 NEXS 038

PY - 2014

Y1 - 2014

N2 - Little is known about the pathophysiology of diabetes in Africans. Thus, we assessed whether insulin resistance and beta-cell function differed by ethnicity in Kenya and whether differences were modified by abdominal fat distribution. A cross-sectional study in 1,087 rural Luo (n = 361), Kamba (n = 378), and Maasai (n = 348) was conducted. All participants had a standard 75-g oral glucose tolerance test (OGTT). Venous blood samples were collected at 0, 30, and 120 min. Serum insulin was analysed at 0 and 30 min. From the OGTT, we assessed the homoeostasis model assessment of insulin resistance by computer model, early phase insulin secretion, and disposition index (DI) dividing insulin secretion by insulin resistance. Abdominal subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) thickness were carried out by ultrasonography. Linear regression analyses were done to assess ethnic differences in insulin indices. The Maasai had 32 and 17 % higher insulin resistance than the Luo and Kamba, respectively (p 

AB - Little is known about the pathophysiology of diabetes in Africans. Thus, we assessed whether insulin resistance and beta-cell function differed by ethnicity in Kenya and whether differences were modified by abdominal fat distribution. A cross-sectional study in 1,087 rural Luo (n = 361), Kamba (n = 378), and Maasai (n = 348) was conducted. All participants had a standard 75-g oral glucose tolerance test (OGTT). Venous blood samples were collected at 0, 30, and 120 min. Serum insulin was analysed at 0 and 30 min. From the OGTT, we assessed the homoeostasis model assessment of insulin resistance by computer model, early phase insulin secretion, and disposition index (DI) dividing insulin secretion by insulin resistance. Abdominal subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) thickness were carried out by ultrasonography. Linear regression analyses were done to assess ethnic differences in insulin indices. The Maasai had 32 and 17 % higher insulin resistance than the Luo and Kamba, respectively (p 

U2 - 10.1007/s00592-013-0474-x

DO - 10.1007/s00592-013-0474-x

M3 - Journal article

C2 - 23563691

VL - 51

SP - 53

EP - 60

JO - Acta Diabetologica

JF - Acta Diabetologica

SN - 0940-5429

IS - 1

ER -

ID: 46896919