Inflammation, non-endothelial dependent coronary microvascular function and diastolic function-Are they linked?

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Inflammation, non-endothelial dependent coronary microvascular function and diastolic function-Are they linked? / Suhrs, Hannah E.; Schrøder, Jakob; Bove, Kira B.; Mygind, Naja D.; Frestad, Daria; Michelsen, Marie M.; Lange, Theis; Gustafsson, Ida; Kastrup, Jens; Prescott, Eva.

I: PLoS ONE, Bind 15, Nr. 7, 0236035, 2020.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Suhrs, HE, Schrøder, J, Bove, KB, Mygind, ND, Frestad, D, Michelsen, MM, Lange, T, Gustafsson, I, Kastrup, J & Prescott, E 2020, 'Inflammation, non-endothelial dependent coronary microvascular function and diastolic function-Are they linked?', PLoS ONE, bind 15, nr. 7, 0236035. https://doi.org/10.1371/journal.pone.0236035

APA

Suhrs, H. E., Schrøder, J., Bove, K. B., Mygind, N. D., Frestad, D., Michelsen, M. M., Lange, T., Gustafsson, I., Kastrup, J., & Prescott, E. (2020). Inflammation, non-endothelial dependent coronary microvascular function and diastolic function-Are they linked? PLoS ONE, 15(7), [0236035]. https://doi.org/10.1371/journal.pone.0236035

Vancouver

Suhrs HE, Schrøder J, Bove KB, Mygind ND, Frestad D, Michelsen MM o.a. Inflammation, non-endothelial dependent coronary microvascular function and diastolic function-Are they linked? PLoS ONE. 2020;15(7). 0236035. https://doi.org/10.1371/journal.pone.0236035

Author

Suhrs, Hannah E. ; Schrøder, Jakob ; Bove, Kira B. ; Mygind, Naja D. ; Frestad, Daria ; Michelsen, Marie M. ; Lange, Theis ; Gustafsson, Ida ; Kastrup, Jens ; Prescott, Eva. / Inflammation, non-endothelial dependent coronary microvascular function and diastolic function-Are they linked?. I: PLoS ONE. 2020 ; Bind 15, Nr. 7.

Bibtex

@article{255a0f0b20464e39964edf1458e86486,

title = "Inflammation, non-endothelial dependent coronary microvascular function and diastolic function-Are they linked?",

abstract = "Purpose Systemic inflammation and coronary microvascular dysfunction (CMD) may be causal drivers of heart failure with preserved ejection fraction (HFpEF). We tested the hypothesis that subclinical inflammation is associated with non-endothelial dependent CMD and diastolic dysfunction. Methods In a cross-sectional study of 336 women with angina but no flow limiting coronary artery stenosis (180 with diabetes) and 95 asymptomatic controls, blood samples were analysed for 90 biomarkers of which 34 were part of inflammatory pathways. CMD was assessed as coronary flow velocity reserve (CFVR) by transthoracic Doppler echocardiography and defined as CFVR10) (p = 0.012). Conclusion This is the first study to link a large number of mainly inflammatory biomarkers to both CMD and E/e', thus confirming a role of inflammation in both conditions. However, despite a high prevalence of CMD, few patients had diastolic dysfunction and the data do not support a major pathophysiologic role of non-endothelial dependent CMD in diastolic dysfunction.",

keywords = "PRESERVED EJECTION FRACTION, HEART-FAILURE, ANGINA-PECTORIS, DYSFUNCTION, RISK, ASSOCIATION, MORTALITY, DISEASE, MARKERS, IPOWER",

author = "Suhrs, {Hannah E.} and Jakob Schr{\o}der and Bove, {Kira B.} and Mygind, {Naja D.} and Daria Frestad and Michelsen, {Marie M.} and Theis Lange and Ida Gustafsson and Jens Kastrup and Eva Prescott",

year = "2020",

doi = "10.1371/journal.pone.0236035",

language = "English",

volume = "15",

journal = "PLoS ONE",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "7",