How to evaluate interaction between causes: a review of practices in cardiovascular epidemiology
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How to evaluate interaction between causes : a review of practices in cardiovascular epidemiology. / Hallqvist, J; Ahlbom, A; Diderichsen, Finn; Reuterwall, C.
I: Journal of Internal Medicine, Bind 239, Nr. 5, 1996, s. 377-82.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - How to evaluate interaction between causes
T2 - a review of practices in cardiovascular epidemiology
AU - Hallqvist, J
AU - Ahlbom, A
AU - Diderichsen, Finn
AU - Reuterwall, C
PY - 1996
Y1 - 1996
N2 - To increase the knowledge of interaction or synergy between risk factors in an important task in medical research. Still, current literature in cardiovascular epidemiology reflects major misconceptions as how to evaluate interaction. This paper presents Rothman's model of causation from which strict empirical criteria of interaction can be derived. In principle, the method to apply consists of comparing risk differences for one risk factor of interest across strata of the other. Commonly used but incorrect approaches are exemplified and discussed. These include reporting risk of disease among those with combined exposure, comparing relative risks for one exposure after stratification by level of the other, and including an interaction term in the regression model and drawing conclusions from its P-value.
AB - To increase the knowledge of interaction or synergy between risk factors in an important task in medical research. Still, current literature in cardiovascular epidemiology reflects major misconceptions as how to evaluate interaction. This paper presents Rothman's model of causation from which strict empirical criteria of interaction can be derived. In principle, the method to apply consists of comparing risk differences for one risk factor of interest across strata of the other. Commonly used but incorrect approaches are exemplified and discussed. These include reporting risk of disease among those with combined exposure, comparing relative risks for one exposure after stratification by level of the other, and including an interaction term in the regression model and drawing conclusions from its P-value.
KW - Cardiovascular Diseases
KW - Causality
KW - Humans
KW - Models, Theoretical
KW - Risk
M3 - Journal article
C2 - 8642229
VL - 239
SP - 377
EP - 382
JO - Acta Medica Scandinavica
JF - Acta Medica Scandinavica
SN - 0955-7873
IS - 5
ER -
ID: 40346425