Household transmission of the SARS-CoV-2 Omicron variant in Denmark

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

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Household transmission of the SARS-CoV-2 Omicron variant in Denmark. / Lyngse, Frederik Plesner; Mortensen, Laust Hvas; Denwood, Matthew J; Christiansen, Lasse Engbo; Møller, Camilla Holten; Skov, Robert Leo; Spiess, Katja; Fomsgaard, Anders; Lassaunière, Ria; Rasmussen, Morten; Stegger, Marc; Nielsen, Claus; Sieber, Raphael Niklaus; Cohen, Arieh Sierra; Møller, Frederik Trier; Overvad, Maria; Mølbak, Kåre; Krause, Tyra Grove; Kirkeby, Carsten Thure.

I: Nature Communications, Bind 13, 5573, 2022.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Lyngse, FP, Mortensen, LH, Denwood, MJ, Christiansen, LE, Møller, CH, Skov, RL, Spiess, K, Fomsgaard, A, Lassaunière, R, Rasmussen, M, Stegger, M, Nielsen, C, Sieber, RN, Cohen, AS, Møller, FT, Overvad, M, Mølbak, K, Krause, TG & Kirkeby, CT 2022, 'Household transmission of the SARS-CoV-2 Omicron variant in Denmark', Nature Communications, bind 13, 5573. https://doi.org/10.1038/s41467-022-33328-3

APA

Lyngse, F. P., Mortensen, L. H., Denwood, M. J., Christiansen, L. E., Møller, C. H., Skov, R. L., Spiess, K., Fomsgaard, A., Lassaunière, R., Rasmussen, M., Stegger, M., Nielsen, C., Sieber, R. N., Cohen, A. S., Møller, F. T., Overvad, M., Mølbak, K., Krause, T. G., & Kirkeby, C. T. (2022). Household transmission of the SARS-CoV-2 Omicron variant in Denmark. Nature Communications, 13, [5573]. https://doi.org/10.1038/s41467-022-33328-3

Vancouver

Lyngse FP, Mortensen LH, Denwood MJ, Christiansen LE, Møller CH, Skov RL o.a. Household transmission of the SARS-CoV-2 Omicron variant in Denmark. Nature Communications. 2022;13. 5573. https://doi.org/10.1038/s41467-022-33328-3

Author

Lyngse, Frederik Plesner ; Mortensen, Laust Hvas ; Denwood, Matthew J ; Christiansen, Lasse Engbo ; Møller, Camilla Holten ; Skov, Robert Leo ; Spiess, Katja ; Fomsgaard, Anders ; Lassaunière, Ria ; Rasmussen, Morten ; Stegger, Marc ; Nielsen, Claus ; Sieber, Raphael Niklaus ; Cohen, Arieh Sierra ; Møller, Frederik Trier ; Overvad, Maria ; Mølbak, Kåre ; Krause, Tyra Grove ; Kirkeby, Carsten Thure. / Household transmission of the SARS-CoV-2 Omicron variant in Denmark. I: Nature Communications. 2022 ; Bind 13.

Bibtex

@article{861bcc84665d4bf79ba2ce0acefb7e47,

title = "Household transmission of the SARS-CoV-2 Omicron variant in Denmark",

abstract = "In late 2021, the Omicron SARS-CoV-2 variant overtook the previously dominant Delta variant, but the extent to which this transition was driven by immune evasion or a change in the inherent transmissibility is currently unclear. We estimate SARS-CoV-2 transmission within Danish households during December 2021. Among 26,675 households (8,568 with the Omicron VOC), we identified 14,140 secondary infections within a 1-7-day follow-up period. The secondary attack rate was 29% and 21% in households infected with Omicron and Delta, respectively. For Omicron, the odds of infection were 1.10 (95%-CI: 1.00-1.21) times higher for unvaccinated, 2.38 (95%-CI: 2.23-2.54) times higher for fully vaccinated and 3.20 (95%-CI: 2.67-3.83) times higher for booster-vaccinated contacts compared to Delta. We conclude that the transition from Delta to Omicron VOC was primarily driven by immune evasiveness and to a lesser extent an inherent increase in the basic transmissibility of the Omicron variant.",

author = "Lyngse, {Frederik Plesner} and Mortensen, {Laust Hvas} and Denwood, {Matthew J} and Christiansen, {Lasse Engbo} and M{\o}ller, {Camilla Holten} and Skov, {Robert Leo} and Katja Spiess and Anders Fomsgaard and Ria Lassauni{\`e}re and Morten Rasmussen and Marc Stegger and Claus Nielsen and Sieber, {Raphael Niklaus} and Cohen, {Arieh Sierra} and M{\o}ller, {Frederik Trier} and Maria Overvad and K{\aa}re M{\o}lbak and Krause, {Tyra Grove} and Kirkeby, {Carsten Thure}",

note = "{\textcopyright} 2022. The Author(s).",

year = "2022",

doi = "10.1038/s41467-022-33328-3",

language = "English",

volume = "13",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Household transmission of the SARS-CoV-2 Omicron variant in Denmark

AU - Lyngse, Frederik Plesner

AU - Mortensen, Laust Hvas

AU - Denwood, Matthew J

AU - Christiansen, Lasse Engbo

AU - Møller, Camilla Holten

AU - Skov, Robert Leo

AU - Spiess, Katja

AU - Fomsgaard, Anders

AU - Lassaunière, Ria

AU - Rasmussen, Morten

AU - Stegger, Marc

AU - Nielsen, Claus

AU - Sieber, Raphael Niklaus

AU - Cohen, Arieh Sierra

AU - Møller, Frederik Trier

AU - Overvad, Maria

AU - Mølbak, Kåre

AU - Krause, Tyra Grove

AU - Kirkeby, Carsten Thure

PY - 2022

Y1 - 2022

N2 - In late 2021, the Omicron SARS-CoV-2 variant overtook the previously dominant Delta variant, but the extent to which this transition was driven by immune evasion or a change in the inherent transmissibility is currently unclear. We estimate SARS-CoV-2 transmission within Danish households during December 2021. Among 26,675 households (8,568 with the Omicron VOC), we identified 14,140 secondary infections within a 1-7-day follow-up period. The secondary attack rate was 29% and 21% in households infected with Omicron and Delta, respectively. For Omicron, the odds of infection were 1.10 (95%-CI: 1.00-1.21) times higher for unvaccinated, 2.38 (95%-CI: 2.23-2.54) times higher for fully vaccinated and 3.20 (95%-CI: 2.67-3.83) times higher for booster-vaccinated contacts compared to Delta. We conclude that the transition from Delta to Omicron VOC was primarily driven by immune evasiveness and to a lesser extent an inherent increase in the basic transmissibility of the Omicron variant.

AB - In late 2021, the Omicron SARS-CoV-2 variant overtook the previously dominant Delta variant, but the extent to which this transition was driven by immune evasion or a change in the inherent transmissibility is currently unclear. We estimate SARS-CoV-2 transmission within Danish households during December 2021. Among 26,675 households (8,568 with the Omicron VOC), we identified 14,140 secondary infections within a 1-7-day follow-up period. The secondary attack rate was 29% and 21% in households infected with Omicron and Delta, respectively. For Omicron, the odds of infection were 1.10 (95%-CI: 1.00-1.21) times higher for unvaccinated, 2.38 (95%-CI: 2.23-2.54) times higher for fully vaccinated and 3.20 (95%-CI: 2.67-3.83) times higher for booster-vaccinated contacts compared to Delta. We conclude that the transition from Delta to Omicron VOC was primarily driven by immune evasiveness and to a lesser extent an inherent increase in the basic transmissibility of the Omicron variant.

U2 - 10.1038/s41467-022-33328-3

DO - 10.1038/s41467-022-33328-3

M3 - Journal article

C2 - 36151099

VL - 13

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 5573

ER -

ID: 320489171