FLUORIDE EFFECT ON THE EPIPHYSEAL GROWTH PLATE EVALUATED BY VERTICAL SECTION STEREOLOGY

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

FLUORIDE EFFECT ON THE EPIPHYSEAL GROWTH PLATE EVALUATED BY VERTICAL SECTION STEREOLOGY. / MOHR, H; KRAGSTRUP, J.

I: Fluoride - Quarterly Reports, Bind 23, Nr. 4, 10.1990, s. 154-163.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

MOHR, H & KRAGSTRUP, J 1990, 'FLUORIDE EFFECT ON THE EPIPHYSEAL GROWTH PLATE EVALUATED BY VERTICAL SECTION STEREOLOGY', Fluoride - Quarterly Reports, bind 23, nr. 4, s. 154-163.

APA

MOHR, H., & KRAGSTRUP, J. (1990). FLUORIDE EFFECT ON THE EPIPHYSEAL GROWTH PLATE EVALUATED BY VERTICAL SECTION STEREOLOGY. Fluoride - Quarterly Reports, 23(4), 154-163.

Vancouver

MOHR H, KRAGSTRUP J. FLUORIDE EFFECT ON THE EPIPHYSEAL GROWTH PLATE EVALUATED BY VERTICAL SECTION STEREOLOGY. Fluoride - Quarterly Reports. 1990 okt.;23(4):154-163.

Author

MOHR, H ; KRAGSTRUP, J. / FLUORIDE EFFECT ON THE EPIPHYSEAL GROWTH PLATE EVALUATED BY VERTICAL SECTION STEREOLOGY. I: Fluoride - Quarterly Reports. 1990 ; Bind 23, Nr. 4. s. 154-163.

Bibtex

@article{3d0f3e77770340c48699d75669b374ff,
title = "FLUORIDE EFFECT ON THE EPIPHYSEAL GROWTH PLATE EVALUATED BY VERTICAL SECTION STEREOLOGY",
abstract = "The objective of this study was to describe the effects of fluoride on the epiphyses of the rat tibia by a newly developed histomorphometric technique for estimation of surface density and surface area of highly organized (anisotropic) organs: vertical section stereology. Seventeen experimental animals receiving drinking water with 100 ppm fluoride for seven weeks were compared with 16 controls. The proximal epiphyseal plate of the right tibia was examined. Morphometric estimates were obtained from vertical sections, i.e., histologic sections cut perpendicular to a defined plane. The thickness of the growth plate was significantly smaller in the fluoride group compared to controls (p < 0.05) due to a reduced thickness of the proliferative zone (p < 0.01). The surface density as well as the total volume of cells in the proliferative zone were significantly reduced in the fluoride group (p < 0.05). It was concluded that fluoride induces quantitative changes in the epiphyseal plate of the rat tibia probably by an effect on supracellular mechanisms.",
keywords = "BONE MODELING, EPIPHYSEAL PLATE, FLUORIDE, HISTOMORPHOMETRY, VERTICAL SECTIONS, EXPERIMENTAL OSTEO-FLUOROSIS, SKELETAL DEVELOPMENT, DENTAL FLUOROSIS, SODIUM-FLUORIDE, TRABECULAR BONE, OSTEOPOROSIS, GIRLS, CELLS, AREA, PIG",
author = "H MOHR and J KRAGSTRUP",
year = "1990",
month = oct,
language = "English",
volume = "23",
pages = "154--163",
journal = "Fluoride - Quarterly Reports",
issn = "0015-4725",
publisher = "International Society for Fluoride Research",
number = "4",

}

RIS

TY - JOUR

T1 - FLUORIDE EFFECT ON THE EPIPHYSEAL GROWTH PLATE EVALUATED BY VERTICAL SECTION STEREOLOGY

AU - MOHR, H

AU - KRAGSTRUP, J

PY - 1990/10

Y1 - 1990/10

N2 - The objective of this study was to describe the effects of fluoride on the epiphyses of the rat tibia by a newly developed histomorphometric technique for estimation of surface density and surface area of highly organized (anisotropic) organs: vertical section stereology. Seventeen experimental animals receiving drinking water with 100 ppm fluoride for seven weeks were compared with 16 controls. The proximal epiphyseal plate of the right tibia was examined. Morphometric estimates were obtained from vertical sections, i.e., histologic sections cut perpendicular to a defined plane. The thickness of the growth plate was significantly smaller in the fluoride group compared to controls (p < 0.05) due to a reduced thickness of the proliferative zone (p < 0.01). The surface density as well as the total volume of cells in the proliferative zone were significantly reduced in the fluoride group (p < 0.05). It was concluded that fluoride induces quantitative changes in the epiphyseal plate of the rat tibia probably by an effect on supracellular mechanisms.

AB - The objective of this study was to describe the effects of fluoride on the epiphyses of the rat tibia by a newly developed histomorphometric technique for estimation of surface density and surface area of highly organized (anisotropic) organs: vertical section stereology. Seventeen experimental animals receiving drinking water with 100 ppm fluoride for seven weeks were compared with 16 controls. The proximal epiphyseal plate of the right tibia was examined. Morphometric estimates were obtained from vertical sections, i.e., histologic sections cut perpendicular to a defined plane. The thickness of the growth plate was significantly smaller in the fluoride group compared to controls (p < 0.05) due to a reduced thickness of the proliferative zone (p < 0.01). The surface density as well as the total volume of cells in the proliferative zone were significantly reduced in the fluoride group (p < 0.05). It was concluded that fluoride induces quantitative changes in the epiphyseal plate of the rat tibia probably by an effect on supracellular mechanisms.

KW - BONE MODELING

KW - EPIPHYSEAL PLATE

KW - FLUORIDE

KW - HISTOMORPHOMETRY

KW - VERTICAL SECTIONS

KW - EXPERIMENTAL OSTEO-FLUOROSIS

KW - SKELETAL DEVELOPMENT

KW - DENTAL FLUOROSIS

KW - SODIUM-FLUORIDE

KW - TRABECULAR BONE

KW - OSTEOPOROSIS

KW - GIRLS

KW - CELLS

KW - AREA

KW - PIG

M3 - Journal article

VL - 23

SP - 154

EP - 163

JO - Fluoride - Quarterly Reports

JF - Fluoride - Quarterly Reports

SN - 0015-4725

IS - 4

ER -

ID: 324332680