TY - JOUR

T1 - Familial risk and heritability of ischemic heart disease and stroke in Danish twins

AU - Osler, Merete

AU - Villumsen, Martin Dalgaard

AU - Jorgensen, Martin Balslev

AU - Hjelmborg, Jacob V. B.

AU - Christensen, Kaare

AU - Wium-Andersen, Marie Kim

PY - 2022

Y1 - 2022

N2 - Aim:Our aim was to explore whether familial factors influence the risk of ischemic heart disease, stroke, and their co-occurrence.Methods:In total, 23,498 monozygotic and 39,540 same-sex dizygotic twins from the Danish Twin Registry were followed from 1977 to 2011 in the Danish National Patient Registry for ischemic heart disease and stroke. Time-to-event analyses accounting for censoring and competing risk of death were used to estimate familial risk (casewise concordance relative to the cumulative incidence) and heritability of ischemic heart disease, stroke, and the co-occurrence by age.Results:During follow-up, we observed 5561 and 4186 twin individuals with ischemic heart disease and stroke respectively, with 936 twin pairs concordant for ischemic heart disease and stroke. Familial risks were significant for both, with higher cumulative risks in monozygotic than in dizygotic twins. Estimates for heritability were significant for ischemic heart disease as well as for stroke diagnosed after the age of 80. The casewise concordance of ischemic heart disease in twins whose co-twin was diagnosed with stroke did not differ for monozygotic and dizygotic twins; however, from age 55 it was 10% higher than the cumulative risk in the overall twin cohort and was 25% higher at age 90. A similar pattern was seen for stroke following the co-twin's ischemic heart disease.

AB - Aim:Our aim was to explore whether familial factors influence the risk of ischemic heart disease, stroke, and their co-occurrence.Methods:In total, 23,498 monozygotic and 39,540 same-sex dizygotic twins from the Danish Twin Registry were followed from 1977 to 2011 in the Danish National Patient Registry for ischemic heart disease and stroke. Time-to-event analyses accounting for censoring and competing risk of death were used to estimate familial risk (casewise concordance relative to the cumulative incidence) and heritability of ischemic heart disease, stroke, and the co-occurrence by age.Results:During follow-up, we observed 5561 and 4186 twin individuals with ischemic heart disease and stroke respectively, with 936 twin pairs concordant for ischemic heart disease and stroke. Familial risks were significant for both, with higher cumulative risks in monozygotic than in dizygotic twins. Estimates for heritability were significant for ischemic heart disease as well as for stroke diagnosed after the age of 80. The casewise concordance of ischemic heart disease in twins whose co-twin was diagnosed with stroke did not differ for monozygotic and dizygotic twins; however, from age 55 it was 10% higher than the cumulative risk in the overall twin cohort and was 25% higher at age 90. A similar pattern was seen for stroke following the co-twin's ischemic heart disease.

KW - Familial risk

KW - ischemic heart disease

KW - stroke

KW - twin cohort study

KW - FOLLOW-UP

KW - REGISTRY

KW - HISTORY

KW - DEATH

U2 - 10.1177/1403494820953322

DO - 10.1177/1403494820953322

M3 - Journal article

C2 - 32880216

VL - 50

SP - 199

EP - 204

JO - Scandinavian Journal of Public Health, Supplement

JF - Scandinavian Journal of Public Health, Supplement

SN - 1403-4956

IS - 2

ER -