Exposure to nitrate from drinking water and the risk of childhood cancer in Denmark
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- Exposure to nitrate from drinking water and the risk of childhood cancer in Denmark
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Background: There is limited evidence that nitrate, a common contaminant in drinking water, increases the risk of childhood cancers. Our objective was to examine this association in Denmark. Methods: We conducted a nationwide case-control study based on all singletons liveborn to Danish-born parents from 1991 to 2015 (N = 1,219,140) that included 596 leukemias, 180 lymphomas, and 310 central nervous system cancers (CNC) who were 25 mg/L nitrate) was observed for preconception (OR = 1.82, 95%CI:1.09 to 3.04), prenatal (OR = 1.65, 95%CI:0.97 to 2.81), and postnatal exposure (OR = 1.48, 95% CI:0.82 to 2.68) in fully adjusted models. There was also some evidence of an exposure-response in models of continuous nitrate exposure and CNC. Conclusions: Our findings provide some evidence that exposure to nitrate from drinking water may increase the risk of childhood CNC cancer, but not leukemia or lymphoma.
Originalsprog | Engelsk |
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Artikelnummer | 106613 |
Tidsskrift | Environment International |
Vol/bind | 155 |
Antal sider | 9 |
ISSN | 0160-4120 |
DOI | |
Status | Udgivet - 2021 |
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ID: 275817740