Environmental cadmium exposure is associated with elevated risk of chronic otitis media in adults
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Environmental cadmium exposure is associated with elevated risk of chronic otitis media in adults. / Lee, Dong-Wook; Oh, Seung-Ha; Park, Moo-Kyun; Lim, Youn-Hee; Hong, Yun-Chul.
I: Occupational and Environmental Medicine, Bind 75, Nr. 7, 2018, s. 515-521.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Environmental cadmium exposure is associated with elevated risk of chronic otitis media in adults
AU - Lee, Dong-Wook
AU - Oh, Seung-Ha
AU - Park, Moo-Kyun
AU - Lim, Youn-Hee
AU - Hong, Yun-Chul
N1 - © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.
PY - 2018
Y1 - 2018
N2 - OBJECTIVES: Chronic otitis media (COM) is caused by an infection of the middle ear, although it may also be associated with environmental pollutants. Recent reports found that cadmium exposure could be toxic to middle ear cell lines, but the role of cadmium in the development of COM in humans has not been examined to date. We hypothesised that environmental cadmium exposure was associated with an increased risk of COM in the general population.METHODS: We analysed cross-sectional data for 5331 adults of 20 years of age or above, obtained from the Korea National Health and Nutrition Examination Survey 2010-2012. We examined the association between blood cadmium levels and COM diagnosed by an otolaryngologist.RESULTS: The highest quartile group of cadmium blood concentration was associated with an OR of 3.33 (95% CI 1.78 to 7.53) for COM, after adjusting for potential confounding factors. Doubling blood cadmium concentration resulted in an OR of 1.58 (95% CI 1.19 to 2.08) for COM. These associations were robust on sensitivity analyses after excluding current smokers and former smokers and after excluding subjects with a potential history of occupational exposure to cadmium.CONCLUSIONS: The results of our study suggest that environmental cadmium exposure is associated with increased risk of COM, and further studies are warranted to understand the pathogenetic mechanism by which COM is caused by cadmium exposure.
AB - OBJECTIVES: Chronic otitis media (COM) is caused by an infection of the middle ear, although it may also be associated with environmental pollutants. Recent reports found that cadmium exposure could be toxic to middle ear cell lines, but the role of cadmium in the development of COM in humans has not been examined to date. We hypothesised that environmental cadmium exposure was associated with an increased risk of COM in the general population.METHODS: We analysed cross-sectional data for 5331 adults of 20 years of age or above, obtained from the Korea National Health and Nutrition Examination Survey 2010-2012. We examined the association between blood cadmium levels and COM diagnosed by an otolaryngologist.RESULTS: The highest quartile group of cadmium blood concentration was associated with an OR of 3.33 (95% CI 1.78 to 7.53) for COM, after adjusting for potential confounding factors. Doubling blood cadmium concentration resulted in an OR of 1.58 (95% CI 1.19 to 2.08) for COM. These associations were robust on sensitivity analyses after excluding current smokers and former smokers and after excluding subjects with a potential history of occupational exposure to cadmium.CONCLUSIONS: The results of our study suggest that environmental cadmium exposure is associated with increased risk of COM, and further studies are warranted to understand the pathogenetic mechanism by which COM is caused by cadmium exposure.
KW - Adult
KW - Aged
KW - Cadmium/adverse effects
KW - Chronic Disease
KW - Cross-Sectional Studies
KW - Environmental Exposure/adverse effects
KW - Environmental Pollutants/adverse effects
KW - Female
KW - Health Surveys
KW - Humans
KW - Male
KW - Middle Aged
KW - Otitis Media/blood
KW - Republic of Korea
KW - Risk Factors
KW - Young Adult
U2 - 10.1136/oemed-2017-104631
DO - 10.1136/oemed-2017-104631
M3 - Journal article
C2 - 29581150
VL - 75
SP - 515
EP - 521
JO - Occupational and Environmental Medicine
JF - Occupational and Environmental Medicine
SN - 1351-0711
IS - 7
ER -
ID: 230068086