Embryo Morphokinetics and Blastocyst Development After GnRH Agonist versus hCG Triggering in Normo-ovulatory Women: a Secondary Analysis of a Multicenter Randomized Controlled Trial
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Embryo Morphokinetics and Blastocyst Development After GnRH Agonist versus hCG Triggering in Normo-ovulatory Women : a Secondary Analysis of a Multicenter Randomized Controlled Trial. / Alexopoulou, Evaggelia; Stormlund, Sacha; Løssl, Kristine; Prætorius, Lisbeth; Sopa, Negjyp; Bogstad, Jeanette Wulff; Mikkelsen, Anne Lis; Forman, Julie; la Cour Freiesleben, Nina; Vikkelsø Jeppesen, Janni; Bergh, Christina; Al Humaidan, Peter Samir Heskjær; Grøndahl, Marie Louise; Zedeler, Anne; Pinborg, Anja Bisgaard.
I: Reproductive Sciences, Bind 28, 2021, s. 2972–2981.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Embryo Morphokinetics and Blastocyst Development After GnRH Agonist versus hCG Triggering in Normo-ovulatory Women
T2 - a Secondary Analysis of a Multicenter Randomized Controlled Trial
AU - Alexopoulou, Evaggelia
AU - Stormlund, Sacha
AU - Løssl, Kristine
AU - Prætorius, Lisbeth
AU - Sopa, Negjyp
AU - Bogstad, Jeanette Wulff
AU - Mikkelsen, Anne Lis
AU - Forman, Julie
AU - la Cour Freiesleben, Nina
AU - Vikkelsø Jeppesen, Janni
AU - Bergh, Christina
AU - Al Humaidan, Peter Samir Heskjær
AU - Grøndahl, Marie Louise
AU - Zedeler, Anne
AU - Pinborg, Anja Bisgaard
PY - 2021
Y1 - 2021
N2 - Gonadotropin-releasing hormone agonist (GnRHa) for final oocyte maturation, along with vitrification of all usable embryos followed by transfer in a subsequent frozen-thawed cycle, is the most effective strategy to avoid ovarian hyperstimulation syndrome (OHSS). However, less is known about the ovulation induction triggers effect on early embryo development and blastocyst formation. This study is a secondary analysis of a multicenter, randomized controlled trial, with the aim to compare embryo development in normo-ovulatory women, randomized to GnRHa or human chorionic gonadotropin (hCG) trigger. In all, 4056 retrieved oocytes were observed, 1998 from the GnRHa group (216 women) and 2058 from the hCG group (218 women). A number of retrieved oocytes, mature and fertilized oocytes, and high-quality embryos and blastocysts were similar between the groups. A sub-analysis in 250 women enrolled at the main trial site including 2073 oocytes was conducted to compare embryo morphokinetics and cleavage patterns with EmbryoScope time-lapse system. In total, 1013 oocytes were retrieved from the GnRHa group (124 women) and 1060 oocytes were retrieved from the hCG group (126 women). Morphokinetic parameters and cleavage patterns were comparable between the groups. However, embryos derived from the GnRHa group were less likely to perform rolling during their development than the embryos from the hCG trigger group (OR = 0.41 (95%CI 0.25; 0.67), p-value 0.0003). The comparable results on embryo development and utilization rates between the GnRHa and hCG triggers is of clinical relevance to professionals and infertile patients, when GnRHa trigger and freeze-all is performed to avoid OHSS development. ClinicalTrials.gov Identifier: NCT02746562
AB - Gonadotropin-releasing hormone agonist (GnRHa) for final oocyte maturation, along with vitrification of all usable embryos followed by transfer in a subsequent frozen-thawed cycle, is the most effective strategy to avoid ovarian hyperstimulation syndrome (OHSS). However, less is known about the ovulation induction triggers effect on early embryo development and blastocyst formation. This study is a secondary analysis of a multicenter, randomized controlled trial, with the aim to compare embryo development in normo-ovulatory women, randomized to GnRHa or human chorionic gonadotropin (hCG) trigger. In all, 4056 retrieved oocytes were observed, 1998 from the GnRHa group (216 women) and 2058 from the hCG group (218 women). A number of retrieved oocytes, mature and fertilized oocytes, and high-quality embryos and blastocysts were similar between the groups. A sub-analysis in 250 women enrolled at the main trial site including 2073 oocytes was conducted to compare embryo morphokinetics and cleavage patterns with EmbryoScope time-lapse system. In total, 1013 oocytes were retrieved from the GnRHa group (124 women) and 1060 oocytes were retrieved from the hCG group (126 women). Morphokinetic parameters and cleavage patterns were comparable between the groups. However, embryos derived from the GnRHa group were less likely to perform rolling during their development than the embryos from the hCG trigger group (OR = 0.41 (95%CI 0.25; 0.67), p-value 0.0003). The comparable results on embryo development and utilization rates between the GnRHa and hCG triggers is of clinical relevance to professionals and infertile patients, when GnRHa trigger and freeze-all is performed to avoid OHSS development. ClinicalTrials.gov Identifier: NCT02746562
KW - Blastocyst formation
KW - Embryo development
KW - GnRHa
KW - hCG
KW - Morphokinetiks
KW - Ovulation trigger
U2 - 10.1007/s43032-021-00564-9
DO - 10.1007/s43032-021-00564-9
M3 - Journal article
C2 - 33847977
AN - SCOPUS:85104527133
VL - 28
SP - 2972
EP - 2981
JO - Reproductive Sciences
JF - Reproductive Sciences
SN - 1933-7191
ER -
ID: 261491675