TY - JOUR

T1 - Effects of home-based specialized palliative care and dyadic psychological intervention on caregiver burden

T2 - results from a randomized controlled trial

AU - von Heymann, Annika

AU - Finsted, Emma

AU - Guldin, Mai-Britt

AU - Andersen, Elisabeth Anne Wreford

AU - Dammeyer, Jesper

AU - Sjøgren, Per

AU - von der Maase, Hans

AU - Benthien, Kirstine S.

AU - Kjellberg, Jakob

AU - Johansen, Christoffer

AU - Bidstrup, Pernille

PY - 2023

Y1 - 2023

N2 - Background The Domus study, a randomized controlled trial (RCT), evaluated the effect of home-based specialized palliative care (SPC) reinforced with a psychological intervention for the patient-caregiver dyad on increasing advanced cancer patients' time spent at home, as opposed to hospitalized, and the number of home deaths. As palliative care extends to include support for patients' families and may thus assist caregivers and decrease demands on them, in this study we evaluated a secondary outcome, caregiver burden. Material and Methods Patients with incurable cancer and their caregivers were randomized (1:1) to care as usual or home-based SPC. Caregiver burden was assessed using the Zarit Burden Interview (ZBI) at baseline and 2, 4, 8 weeks and 6 months after randomization. Intervention effects were assessed in mixed effects models. Results A total of 258 caregivers were enrolled. Eleven per cent of informal caregivers experienced severe caregiver burden at baseline. Caregiver burden increased significantly over time in both groups ( p  = 0.0003), but no significant effect of the intervention was seen on overall caregiver burden ( p  = 0.5046) or burden subscales measuring role and personal strain. Conclusion In line with the majority of previous RCTs, the Domus intervention was not able to significantly reduce caregiver burden. Future interventions should consider targeting only caregivers reporting the greatest caregiver burden.

AB - Background The Domus study, a randomized controlled trial (RCT), evaluated the effect of home-based specialized palliative care (SPC) reinforced with a psychological intervention for the patient-caregiver dyad on increasing advanced cancer patients' time spent at home, as opposed to hospitalized, and the number of home deaths. As palliative care extends to include support for patients' families and may thus assist caregivers and decrease demands on them, in this study we evaluated a secondary outcome, caregiver burden. Material and Methods Patients with incurable cancer and their caregivers were randomized (1:1) to care as usual or home-based SPC. Caregiver burden was assessed using the Zarit Burden Interview (ZBI) at baseline and 2, 4, 8 weeks and 6 months after randomization. Intervention effects were assessed in mixed effects models. Results A total of 258 caregivers were enrolled. Eleven per cent of informal caregivers experienced severe caregiver burden at baseline. Caregiver burden increased significantly over time in both groups ( p  = 0.0003), but no significant effect of the intervention was seen on overall caregiver burden ( p  = 0.5046) or burden subscales measuring role and personal strain. Conclusion In line with the majority of previous RCTs, the Domus intervention was not able to significantly reduce caregiver burden. Future interventions should consider targeting only caregivers reporting the greatest caregiver burden.

U2 - 10.1080/0284186X.2023.2194491

DO - 10.1080/0284186X.2023.2194491

M3 - Journal article

C2 - 37010505

VL - 62

SP - 803

EP - 807

JO - Acta Oncologica

JF - Acta Oncologica

SN - 1100-1704

IS - 7

ER -