Does height and IGF-I determine pubertal timing in girls?

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Does height and IGF-I determine pubertal timing in girls? / Upners, Emmie N.; Busch, Alexander S.; Almstrup, Kristian; Petersen, Jørgen H.; Assens, Maria; Main, Katharina M.; Jensen, Rikke B.; Juul, Anders.

I: Pediatric Research, Bind 90, 2021, s. 176–183.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Upners, EN, Busch, AS, Almstrup, K, Petersen, JH, Assens, M, Main, KM, Jensen, RB & Juul, A 2021, 'Does height and IGF-I determine pubertal timing in girls?', Pediatric Research, bind 90, s. 176–183. https://doi.org/10.1038/s41390-020-01215-6

APA

Upners, E. N., Busch, A. S., Almstrup, K., Petersen, J. H., Assens, M., Main, K. M., Jensen, R. B., & Juul, A. (2021). Does height and IGF-I determine pubertal timing in girls? Pediatric Research, 90, 176–183. https://doi.org/10.1038/s41390-020-01215-6

Vancouver

Upners EN, Busch AS, Almstrup K, Petersen JH, Assens M, Main KM o.a. Does height and IGF-I determine pubertal timing in girls? Pediatric Research. 2021;90:176–183. https://doi.org/10.1038/s41390-020-01215-6

Author

Upners, Emmie N. ; Busch, Alexander S. ; Almstrup, Kristian ; Petersen, Jørgen H. ; Assens, Maria ; Main, Katharina M. ; Jensen, Rikke B. ; Juul, Anders. / Does height and IGF-I determine pubertal timing in girls?. I: Pediatric Research. 2021 ; Bind 90. s. 176–183.

Bibtex

@article{5f5a1169dd024487b37ab5fe4a15a5e1,

title = "Does height and IGF-I determine pubertal timing in girls?",

abstract = "Background: Pubertal timing is closely linked to growth regulated by the growth hormone/insulin-like factor (GH/IGF) axis that includes IGF-regulating factors such as pregnancy-associated plasma protein-A/A2 (PAPP-A/PAPP-A2) and stanniocalcin 2 (STC2). We investigated the association between height, IGF-I concentration, and PAPPA, PAPPA2, and STC2 genotypes on the timing of female pubertal milestones. Methods: Height, IGF-I, and genotypes were analyzed in 1382 Danish girls from the general population, 67 patients with tall stature (height ≥2 SD), and 124 patients with short stature (height ≤−2 SD). The main outcomes were breast stage and menarche. Results: Thelarche occurred significantly earlier in patients with tall stature (mean age 9.37 years [95% confidence interval (CI) 8.87–9.87]) and later in patients with short stature (11.07 years [95% CI 10.7–11.43]) compared with girls within the normal range (9.96 years [95% CI 9.85–10.07]) (p = 0.02 and p < 0.01, respectively). Girls with higher IGF-I levels experienced thelarche and menarche earlier compared with the rest of the cohort (p < 0.01). Genotypes were not associated with age at thelarche nor menarche, but the PAPPA2 minor allele carriers were shorter compared with major allele carriers, p = 0.03. Conclusions: Height and IGF-I, but not PAPP-A, PAPP-A2, and STC2 genotypes, were negatively associated with age at thelarche and menarche. Impact: Girls with tall and short stature enter puberty earlier and later compared with girls with normal height.Girls with higher insulin-growth factor-I in childhood enter puberty earlier.Pubertal timing is influenced by longitudinal growth and IGF-I levels earlier in childhood.Childhood growth and the levels of IGF-I in childhood may be biomarkers of pubertal timing.",

author = "Upners, {Emmie N.} and Busch, {Alexander S.} and Kristian Almstrup and Petersen, {J{\o}rgen H.} and Maria Assens and Main, {Katharina M.} and Jensen, {Rikke B.} and Anders Juul",

year = "2021",

doi = "10.1038/s41390-020-01215-6",

language = "English",

volume = "90",

pages = "176–183",

journal = "Pediatric Research",

issn = "0031-3998",

publisher = "nature publishing group",