Does fetal sex influence the risk of venous thrombosis in pregnancy? A cohort study
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Background: Venous thromboembolism is a prominent cause of maternal death. Objective: As inflammation is a well-known risk factor for venous thromboembolism and several studies have found a higher grade of inflammation in pregnancies bearing a male compared with female fetuses, we investigated the risk of pregnancy-related venous thromboembolism associated with sex of the fetus. Methods: This cohort study linked data from national registries and compared event rates and hazard ratios of venous thrombosis for pregnancies bearing a male fetus with those bearing a female fetus during pregnancy and in the first 3 months postpartum. National data from 1995 to 2017 were used. All Danish women aged 15 to 49 years with a live or stillbirth were eligible for inclusion; 1 370 583 pregnancies were included. Women with venous thrombosis, ischemic heart disease, cerebrovascular disease, thrombophilia, or cancer before conception were excluded. Results: The event rate for a venous thrombosis was 8.0 per 10.000 pregnancy years with a male fetus compared with 6.8 for a female fetus. The adjusted hazard ratio for venous thrombosis during pregnancies bearing a male was 1.2 (95% CI, 1.1-1.4), whereas in the postpartum period, it was 0.9 (95% CI, 0.7-1.0). The risk was elevated until week 30. Conclusion: These findings indicate a slightly greater risk of venous thrombosis during pregnancies bearing a male fetus than during pregnancies bearing a female fetus. There was no increased risk associated with fetal male sex in the postpartum period.
Originalsprog | Engelsk |
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Tidsskrift | Journal of Thrombosis and Haemostasis |
Vol/bind | 21 |
Udgave nummer | 3 |
Sider (fra-til) | 599-605 |
Antal sider | 7 |
ISSN | 1538-7933 |
DOI | |
Status | Udgivet - 2023 |
Bibliografisk note
Funding Information:
R.A.V., A.P.M, Ø.L., C.T.-P., T.B., K.J.R., and E.L. have completed the ICMJE uniform disclosure form at www.icmje.org/coi_disclosure and declare all statistical analysis was supported by the Department of Gynaecology, Rigshospitalet , University of Copenhagen , The Research Fund of Rigshospitalet, Copenhagen University Hospital, and grant number E-22515-01. No other disclosures were reported.
Publisher Copyright:
© 2022 International Society on Thrombosis and Haemostasis
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