Disseminated Mycobacterium avium complex infection in a woman with anti-interferon-gamma autoantibodies

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Standard

Disseminated Mycobacterium avium complex infection in a woman with anti-interferon-gamma autoantibodies. / Dahl, Victor Naestholt; Nielsen, Bibi Uhre; Wejse, Christian Morberg; Marquart, Hanne Vibeke; Bay, Jakob Thaning; von Stemann, Jakob Hjorth; Lillebæk, Troels; Andersen, Aase Bengaard.

I: IDCases, Bind 26, e01300, 2021.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Dahl, VN, Nielsen, BU, Wejse, CM, Marquart, HV, Bay, JT, von Stemann, JH, Lillebæk, T & Andersen, AB 2021, 'Disseminated Mycobacterium avium complex infection in a woman with anti-interferon-gamma autoantibodies', IDCases, bind 26, e01300. https://doi.org/10.1016/j.idcr.2021.e01300

APA

Dahl, V. N., Nielsen, B. U., Wejse, C. M., Marquart, H. V., Bay, J. T., von Stemann, J. H., Lillebæk, T., & Andersen, A. B. (2021). Disseminated Mycobacterium avium complex infection in a woman with anti-interferon-gamma autoantibodies. IDCases, 26, [e01300]. https://doi.org/10.1016/j.idcr.2021.e01300

Vancouver

Dahl VN, Nielsen BU, Wejse CM, Marquart HV, Bay JT, von Stemann JH o.a. Disseminated Mycobacterium avium complex infection in a woman with anti-interferon-gamma autoantibodies. IDCases. 2021;26. e01300. https://doi.org/10.1016/j.idcr.2021.e01300

Author

Dahl, Victor Naestholt ; Nielsen, Bibi Uhre ; Wejse, Christian Morberg ; Marquart, Hanne Vibeke ; Bay, Jakob Thaning ; von Stemann, Jakob Hjorth ; Lillebæk, Troels ; Andersen, Aase Bengaard. / Disseminated Mycobacterium avium complex infection in a woman with anti-interferon-gamma autoantibodies. I: IDCases. 2021 ; Bind 26.

Bibtex

@article{67ea402a0f804d6faef0d6b9243759a8,
title = "Disseminated Mycobacterium avium complex infection in a woman with anti-interferon-gamma autoantibodies",
abstract = "Defects in the interleukin-12/interferon-gamma (IFN-γ) pathway and anti-IFN-γ antibodies have been associated with severe nontuberculous mycobacteria (NTM) infections. Consequently, disseminated NTM infections should prompt investigations for immunodeficiency. Herein, we report a case of a treatment refractory and ultimately disseminated and fatal Mycobacterium avium complex infection in a 71-year-old woman of Thai origin. Simultaneously, she had recurrent Salmonella kentucky cultured from stool samples and chronic perianal HSV-2 lesions. Late in the course of disease, anti–IFN-γ autoantibodies were demonstrated. Clinical studies investigating immunomodulating therapy and treatment among patients with anti-IFN-γ autoantibodies are lacking and, in this case, treatment seemed of a more palliative nature.",
keywords = "Nontuberculous mycobacteria, Mycobacterium avium complex, Immunodeficiency, Anti-IFN-gamma autoantibodies",
author = "Dahl, {Victor Naestholt} and Nielsen, {Bibi Uhre} and Wejse, {Christian Morberg} and Marquart, {Hanne Vibeke} and Bay, {Jakob Thaning} and {von Stemann}, {Jakob Hjorth} and Troels Lilleb{\ae}k and Andersen, {Aase Bengaard}",
year = "2021",
doi = "10.1016/j.idcr.2021.e01300",
language = "English",
volume = "26",
journal = "IDCases",
issn = "2214-2509",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Disseminated Mycobacterium avium complex infection in a woman with anti-interferon-gamma autoantibodies

AU - Dahl, Victor Naestholt

AU - Nielsen, Bibi Uhre

AU - Wejse, Christian Morberg

AU - Marquart, Hanne Vibeke

AU - Bay, Jakob Thaning

AU - von Stemann, Jakob Hjorth

AU - Lillebæk, Troels

AU - Andersen, Aase Bengaard

PY - 2021

Y1 - 2021

N2 - Defects in the interleukin-12/interferon-gamma (IFN-γ) pathway and anti-IFN-γ antibodies have been associated with severe nontuberculous mycobacteria (NTM) infections. Consequently, disseminated NTM infections should prompt investigations for immunodeficiency. Herein, we report a case of a treatment refractory and ultimately disseminated and fatal Mycobacterium avium complex infection in a 71-year-old woman of Thai origin. Simultaneously, she had recurrent Salmonella kentucky cultured from stool samples and chronic perianal HSV-2 lesions. Late in the course of disease, anti–IFN-γ autoantibodies were demonstrated. Clinical studies investigating immunomodulating therapy and treatment among patients with anti-IFN-γ autoantibodies are lacking and, in this case, treatment seemed of a more palliative nature.

AB - Defects in the interleukin-12/interferon-gamma (IFN-γ) pathway and anti-IFN-γ antibodies have been associated with severe nontuberculous mycobacteria (NTM) infections. Consequently, disseminated NTM infections should prompt investigations for immunodeficiency. Herein, we report a case of a treatment refractory and ultimately disseminated and fatal Mycobacterium avium complex infection in a 71-year-old woman of Thai origin. Simultaneously, she had recurrent Salmonella kentucky cultured from stool samples and chronic perianal HSV-2 lesions. Late in the course of disease, anti–IFN-γ autoantibodies were demonstrated. Clinical studies investigating immunomodulating therapy and treatment among patients with anti-IFN-γ autoantibodies are lacking and, in this case, treatment seemed of a more palliative nature.

KW - Nontuberculous mycobacteria

KW - Mycobacterium avium complex

KW - Immunodeficiency

KW - Anti-IFN-gamma autoantibodies

U2 - 10.1016/j.idcr.2021.e01300

DO - 10.1016/j.idcr.2021.e01300

M3 - Journal article

C2 - 34692415

VL - 26

JO - IDCases

JF - IDCases

SN - 2214-2509

M1 - e01300

ER -

ID: 283735045