Digit ratio (2D:4D) is not related to cardiovascular diseases or their risk factors in menopausal women
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Digit ratio (2D:4D) is not related to cardiovascular diseases or their risk factors in menopausal women. / Fischer Pedersen, Josefine K; Klimek, Magdalena; Galbarczyk, Andrzej; Nenko, Ilona; Sobocki, Jakob; Christensen, Dirk L; Jasienska, Grazyna.
I: American journal of human biology : the official journal of the Human Biology Council, Bind 33, Nr. 3, e23505, 2021.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Digit ratio (2D:4D) is not related to cardiovascular diseases or their risk factors in menopausal women
AU - Fischer Pedersen, Josefine K
AU - Klimek, Magdalena
AU - Galbarczyk, Andrzej
AU - Nenko, Ilona
AU - Sobocki, Jakob
AU - Christensen, Dirk L
AU - Jasienska, Grazyna
N1 - © 2020 Wiley Periodicals LLC.
PY - 2021
Y1 - 2021
N2 - OBJECTIVES: Digit ratio (2D:4D) is widely used as a biomarker of prenatal hormonal environment linked to the growing number of adult health and disease-related characteristics. It has been suggested that 2D:4D is a good predictor of cardiovascular diseases (CVD) risk among men, but results in women are still inconclusive. Here we test the relationship between 2D:4D and the incidence of cardiovascular diseases (CVD), and their risk factors in Polish, rural women.METHODS: The participants were 410 women age 50 and older. Structured questionnaire was used to gather personal and medical data, including the history of CVD diagnosed by a medical doctor. Anthropometric measurements of body height, weight, and finger lengths were performed. Right-hand and left-hand 2D:4D, mean 2D:4D, Dl-r , and BMI were calculated afterward. For a subgroup of participants (n = 329) fasting blood sample was collected (in order to assess the lipid profile and glucose levels) and blood pressure was measured. Age, education level and BMI were included as potential covariates.RESULTS: No statistically significant association was observed between 2D:4D markers and the incidence of CVD (eg, heart attack, stroke) or CVD risk factors (dyslipidaemia, dysglycaemia or hypertension), when controlled for age, education and BMI.CONCLUSIONS: The results of our study add to the growing number of studies investigating the sex-difference of the association between 2D:4D and cardiac health. We conclude that from a public health perspective 2D:4D may not be a valuable biomarker of elevated risk of CVDs in women.
AB - OBJECTIVES: Digit ratio (2D:4D) is widely used as a biomarker of prenatal hormonal environment linked to the growing number of adult health and disease-related characteristics. It has been suggested that 2D:4D is a good predictor of cardiovascular diseases (CVD) risk among men, but results in women are still inconclusive. Here we test the relationship between 2D:4D and the incidence of cardiovascular diseases (CVD), and their risk factors in Polish, rural women.METHODS: The participants were 410 women age 50 and older. Structured questionnaire was used to gather personal and medical data, including the history of CVD diagnosed by a medical doctor. Anthropometric measurements of body height, weight, and finger lengths were performed. Right-hand and left-hand 2D:4D, mean 2D:4D, Dl-r , and BMI were calculated afterward. For a subgroup of participants (n = 329) fasting blood sample was collected (in order to assess the lipid profile and glucose levels) and blood pressure was measured. Age, education level and BMI were included as potential covariates.RESULTS: No statistically significant association was observed between 2D:4D markers and the incidence of CVD (eg, heart attack, stroke) or CVD risk factors (dyslipidaemia, dysglycaemia or hypertension), when controlled for age, education and BMI.CONCLUSIONS: The results of our study add to the growing number of studies investigating the sex-difference of the association between 2D:4D and cardiac health. We conclude that from a public health perspective 2D:4D may not be a valuable biomarker of elevated risk of CVDs in women.
U2 - 10.1002/ajhb.23505
DO - 10.1002/ajhb.23505
M3 - Journal article
C2 - 32936511
VL - 33
JO - American Journal of Human Biology
JF - American Journal of Human Biology
SN - 1042-0533
IS - 3
M1 - e23505
ER -
ID: 248702137