TY - JOUR

T1 - Differentiation Between Benign and Malignant Pigmented Skin Tumours Using Bedside Diagnostic Imaging Technologies

T2 - A Pilot Study

AU - von Knorring, Terese

AU - Møller Israelsen, Niels

AU - Ung, Vilde

AU - Formann, Julie L.

AU - Jensen, Mikkel

AU - Haedersdal, Merete

AU - Bang, Ole

AU - Fredman, Gabriella

AU - Mogensen, Mette

N1 - Publisher Copyright: © 2022, Medical Journals/Acta D-V. All rights reserved.

PY - 2022

Y1 - 2022

N2 - Rapid diagnosis of suspicious pigmented skin lesions is imperative; however, current bedside skin imaging technologies are either limited in penetration depth or resolution. Combining imaging methods is there-fore highly relevant for skin cancer diagnostics. This pilot study evaluated the ability of optical coherence tomography, reflectance confocal microscopy, photo-acoustic imaging and high-frequency ultrasound to differentiate malignant from benign pigmented skin lesions. A total of 41 pigmented skin tumours were scanned prior to excision. Morphological features and blood vessel characteristics were analysed with reflectance confocal microscopy, optical coherence tomography, high-frequency ultrasound and photoacoustic imaging images, and the diagnostic accuracy was assessed. Three novel photoacous-tic imaging features, 7 reflectance confocal microscopy features, and 2 optical coherence tomography features were detected that had a high correlation with malignancy; diagnostic accuracy > 71%. No significant features were found in high-frequency ultrasound. In conclusion, optical coherence tomo-graphy, reflectance confocal microscopy and pho-toacoustic imaging in combination enable image-guided bedside evaluation of suspicious pigmented skin tumours. Combining these advanced techniques may enable more efficient diagnosis of skin cancer.

AB - Rapid diagnosis of suspicious pigmented skin lesions is imperative; however, current bedside skin imaging technologies are either limited in penetration depth or resolution. Combining imaging methods is there-fore highly relevant for skin cancer diagnostics. This pilot study evaluated the ability of optical coherence tomography, reflectance confocal microscopy, photo-acoustic imaging and high-frequency ultrasound to differentiate malignant from benign pigmented skin lesions. A total of 41 pigmented skin tumours were scanned prior to excision. Morphological features and blood vessel characteristics were analysed with reflectance confocal microscopy, optical coherence tomography, high-frequency ultrasound and photoacoustic imaging images, and the diagnostic accuracy was assessed. Three novel photoacous-tic imaging features, 7 reflectance confocal microscopy features, and 2 optical coherence tomography features were detected that had a high correlation with malignancy; diagnostic accuracy > 71%. No significant features were found in high-frequency ultrasound. In conclusion, optical coherence tomo-graphy, reflectance confocal microscopy and pho-toacoustic imaging in combination enable image-guided bedside evaluation of suspicious pigmented skin tumours. Combining these advanced techniques may enable more efficient diagnosis of skin cancer.

KW - Angiography

KW - Confocal microscopy

KW - Diagnostic imaging

KW - Optical coherence tomography

KW - Photoacoustic techniques

KW - Pigmented skin neoplasm

U2 - 10.2340/actadv.v101.571

DO - 10.2340/actadv.v101.571

M3 - Journal article

C2 - 34806755

AN - SCOPUS:85123878130

VL - 102

JO - Acta Dermato-Venereologica

JF - Acta Dermato-Venereologica

SN - 0001-5555

M1 - adv00634

ER -