TY - JOUR

T1 - Default mode network functional connectivity negatively associated with trait openness to experience

AU - Marstrand-Joergensen, Maja Rou

AU - Madsen, Martin K.

AU - Stenbæk, Dea S.

AU - Ozenne, Brice

AU - Jensen, Peter S.

AU - Frøkjær, Vibe G.

AU - Knudsen, Gitte M.

AU - Fisher, Patrick M.

N1 - Publisher Copyright: © 2021 The Author(s) 2021. Published by Oxford University Press.

PY - 2021

Y1 - 2021

N2 - Evaluating associations between the five-factor personality domains and resting-state functional connectivity networks (e.g. default mode network, DMN) highlights distributed neurobiological systems linked to behaviorally relevant phenotypes. Establishing these associations can highlight a potential underlying role for these neural pathways in related clinical illness and treatment response. Here, we examined associations between within- and between-network resting-state functional connectivity with functional magnetic resonance imaging and the five-factor personality domains: Openness to experience (Openness), Extraversion, Neuroticism, Agreeableness and Conscientiousness. We included data from 470 resting-state scan sessions and personality assessments in 295 healthy participants. Within- and between-network functional connectivity from 32 a priori defined regions was computed across seven resting-state networks. The association between functional connectivity and personality traits was assessed using generalized least squares. Within-network DMN functional connectivity was significantly negatively associated with trait Openness (regression coefficient = -0.0010; [95% confidence interval] = [-0.0017, -0.0003]; PFWER = 0.033), seemingly driven by association with the Fantasy subfacet. Trait Extraversion was significantly negatively associated with functional connectivity between the visual and dorsal attention networks and positively associated with functional connectivity between the frontoparietal and language networks. Our findings provide evidence that resting-state DMN is associated with trait Openness and gives insight into personality neuroscience.

AB - Evaluating associations between the five-factor personality domains and resting-state functional connectivity networks (e.g. default mode network, DMN) highlights distributed neurobiological systems linked to behaviorally relevant phenotypes. Establishing these associations can highlight a potential underlying role for these neural pathways in related clinical illness and treatment response. Here, we examined associations between within- and between-network resting-state functional connectivity with functional magnetic resonance imaging and the five-factor personality domains: Openness to experience (Openness), Extraversion, Neuroticism, Agreeableness and Conscientiousness. We included data from 470 resting-state scan sessions and personality assessments in 295 healthy participants. Within- and between-network functional connectivity from 32 a priori defined regions was computed across seven resting-state networks. The association between functional connectivity and personality traits was assessed using generalized least squares. Within-network DMN functional connectivity was significantly negatively associated with trait Openness (regression coefficient = -0.0010; [95% confidence interval] = [-0.0017, -0.0003]; PFWER = 0.033), seemingly driven by association with the Fantasy subfacet. Trait Extraversion was significantly negatively associated with functional connectivity between the visual and dorsal attention networks and positively associated with functional connectivity between the frontoparietal and language networks. Our findings provide evidence that resting-state DMN is associated with trait Openness and gives insight into personality neuroscience.

KW - default mode network

KW - generalized least squares

KW - personality neuroscience

KW - resting-state fMRI

KW - trait openness

U2 - 10.1093/scan/nsab048

DO - 10.1093/scan/nsab048

M3 - Journal article

C2 - 33891043

AN - SCOPUS:85116958389

VL - 16

SP - 950

EP - 961

JO - Social Cognitive and Affective Neuroscience

JF - Social Cognitive and Affective Neuroscience

SN - 1749-5024

IS - 9

ER -