Decreasing incidence of foot ulcer among patients with type 1 and type 2 diabetes in the period 2001-2014
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Decreasing incidence of foot ulcer among patients with type 1 and type 2 diabetes in the period 2001-2014. / Rasmussen, A.; Almdal, T.; Nielsen, A. Anker; Nielsen, K. E.; Jørgensen, M. E.; Hangaard, S.; Siersma, V.; Holstein, P. E.
I: Diabetes Research and Clinical Practice, Bind 130, 08.2017, s. 221-228.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Decreasing incidence of foot ulcer among patients with type 1 and type 2 diabetes in the period 2001-2014
AU - Rasmussen, A.
AU - Almdal, T.
AU - Nielsen, A. Anker
AU - Nielsen, K. E.
AU - Jørgensen, M. E.
AU - Hangaard, S.
AU - Siersma, V.
AU - Holstein, P. E.
PY - 2017/8
Y1 - 2017/8
N2 - Aim: Diabetic foot ulcer (DFU) is a serious complication to diabetes. The aim was to study the incidence of first DFU among patients with type 1 (T1DM) and type 2 diabetes (T2DM), stratified according to etiology: neuropathic, neuro-ischemic or ischemic, over a period of 14 years (2001–2014).Methods: DFU incidence rates were calculated from electronic patient record data from patients with T1DM and complicated T2DM from a large specialized diabetes hospital with a multidisciplinary foot clinic in Denmark. Poisson regression was used to model incidence of first DFU according to calendar year, diabetes type and etiology.Results: Among 5640 patients with T1DM 255 developed a DFU, corresponding to an incidence of 5.8 (95% confidence interval (95%CI) 5.1–6.5) per 1000 patient years; this incidence dropped from 8.1 (95%CI 5.4–11.9) per 1000 patient years in 2002 to 2.6 (95%CI 1.3–5.3) in 2014 (p = 0.0059). Among 6953 patients with T2DM 310 developed a DFU, corresponding to an incidence of 11.3 (95%CI 10.1–12.6) per 1000 patient years; this incidence dropped from 17.0 (95%CI 12.2–23.8) per 1000 patient years in 2002 to 8.7 (95%CI 5.3–14.1) per 1000 patient year (p = 0.0260) in 2014.Conclusion: The incidence of DFU has decreased substantially in T1DM as well as in T2DM. This change was driven by a decrease in incidence of neuropathic ulcers.
AB - Aim: Diabetic foot ulcer (DFU) is a serious complication to diabetes. The aim was to study the incidence of first DFU among patients with type 1 (T1DM) and type 2 diabetes (T2DM), stratified according to etiology: neuropathic, neuro-ischemic or ischemic, over a period of 14 years (2001–2014).Methods: DFU incidence rates were calculated from electronic patient record data from patients with T1DM and complicated T2DM from a large specialized diabetes hospital with a multidisciplinary foot clinic in Denmark. Poisson regression was used to model incidence of first DFU according to calendar year, diabetes type and etiology.Results: Among 5640 patients with T1DM 255 developed a DFU, corresponding to an incidence of 5.8 (95% confidence interval (95%CI) 5.1–6.5) per 1000 patient years; this incidence dropped from 8.1 (95%CI 5.4–11.9) per 1000 patient years in 2002 to 2.6 (95%CI 1.3–5.3) in 2014 (p = 0.0059). Among 6953 patients with T2DM 310 developed a DFU, corresponding to an incidence of 11.3 (95%CI 10.1–12.6) per 1000 patient years; this incidence dropped from 17.0 (95%CI 12.2–23.8) per 1000 patient years in 2002 to 8.7 (95%CI 5.3–14.1) per 1000 patient year (p = 0.0260) in 2014.Conclusion: The incidence of DFU has decreased substantially in T1DM as well as in T2DM. This change was driven by a decrease in incidence of neuropathic ulcers.
KW - Foot ulcer
KW - Peripheral neuropathy
KW - Diabetes complications
KW - Type 1 diabetes
KW - Type 2 diabetes
U2 - 10.1016/j.diabres.2017.05.025
DO - 10.1016/j.diabres.2017.05.025
M3 - Journal article
C2 - 28648855
VL - 130
SP - 221
EP - 228
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
SN - 0168-8227
ER -
ID: 188452836