Contribution of the ex vivo placental perfusion model in understanding transplacental immunoglobulin G transfer

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Dokumenter

  • Fulltext

    Forlagets udgivne version, 2,05 MB, PDF-dokument

  • Kine Marita Knudsen Sand
  • Michael M. Gruber
  • Inger Sandlie
  • Mathiesen, Line
  • Jan Terje Andersen
  • Christian Wadsack

Introduction: The acquisition of humoral immunity in utero is essential for the fetus. The crucial protein, which is responsible for this part of immunity, is immunoglobulin-G (IgG). Immune functions of IgGs are mediated via the interaction of the crystallizable fragment (Fc) region of IgG with specific Fc gamma receptors (Fc gamma Rs). However, an atypical Fc gamma R, the neonatal Fc receptor (FcRn), is a key regulator of IgG transfer across the human placenta. During the last four decades ex vivo placental perfusion studies have contributed significantly to the study of mechanisms of IgG transfer across the multicellular placental barrier. Method: A PubMed search was conducted by using specific keywords: placenta, perfusion and IgG to review manuscripts using human placental perfusion to study the transplacental transfer of IgG. Relevant studies found in reference lists of these manuscripts were also added to the review, and references were included that supported or gave nuance to the discussion of the mechanisms of IgG kinetics in the placenta. Results and Discussion: We found twenty publications on the study of transplacental transfer of IgG using human ex vivo placental perfusion, by research groups with partly different settings. This review summarizes knowledge about placental IgG transfer, with a strong focus on the contributions from ex vivo placental perfusion studies.

Superscript/Subscript Available

OriginalsprogEngelsk
TidsskriftPlacenta
Vol/bind127
Sider (fra-til)77-87
Antal sider11
ISSN0143-4004
DOI
StatusUdgivet - 2022

Antal downloads er baseret på statistik fra Google Scholar og www.ku.dk


Ingen data tilgængelig

ID: 322331481