Cognitive remediation plus standard treatment versus standard treatment alone for individuals at ultra-high risk of developing psychosis: Results of the FOCUS randomised clinical trial

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Standard

Cognitive remediation plus standard treatment versus standard treatment alone for individuals at ultra-high risk of developing psychosis : Results of the FOCUS randomised clinical trial. / Glenthoj, Louise B.; Mariegaard, Lise S.; Fagerlund, Birgitte; Jepsen, Jens R. M.; Kristensen, Tina D.; Wenneberg, Christina; Krakauer, Kristine; Medalia, Alice; Roberts, David L.; Hjorthoj, Carsten; Nordentoft, Merete.

I: Schizophrenia Research, Bind 224, 2020, s. 151-158.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Glenthoj, LB, Mariegaard, LS, Fagerlund, B, Jepsen, JRM, Kristensen, TD, Wenneberg, C, Krakauer, K, Medalia, A, Roberts, DL, Hjorthoj, C & Nordentoft, M 2020, 'Cognitive remediation plus standard treatment versus standard treatment alone for individuals at ultra-high risk of developing psychosis: Results of the FOCUS randomised clinical trial', Schizophrenia Research, bind 224, s. 151-158. https://doi.org/10.1016/j.schres.2020.08.016

APA

Glenthoj, L. B., Mariegaard, L. S., Fagerlund, B., Jepsen, J. R. M., Kristensen, T. D., Wenneberg, C., Krakauer, K., Medalia, A., Roberts, D. L., Hjorthoj, C., & Nordentoft, M. (2020). Cognitive remediation plus standard treatment versus standard treatment alone for individuals at ultra-high risk of developing psychosis: Results of the FOCUS randomised clinical trial. Schizophrenia Research, 224, 151-158. https://doi.org/10.1016/j.schres.2020.08.016

Vancouver

Glenthoj LB, Mariegaard LS, Fagerlund B, Jepsen JRM, Kristensen TD, Wenneberg C o.a. Cognitive remediation plus standard treatment versus standard treatment alone for individuals at ultra-high risk of developing psychosis: Results of the FOCUS randomised clinical trial. Schizophrenia Research. 2020;224:151-158. https://doi.org/10.1016/j.schres.2020.08.016

Author

Glenthoj, Louise B. ; Mariegaard, Lise S. ; Fagerlund, Birgitte ; Jepsen, Jens R. M. ; Kristensen, Tina D. ; Wenneberg, Christina ; Krakauer, Kristine ; Medalia, Alice ; Roberts, David L. ; Hjorthoj, Carsten ; Nordentoft, Merete. / Cognitive remediation plus standard treatment versus standard treatment alone for individuals at ultra-high risk of developing psychosis : Results of the FOCUS randomised clinical trial. I: Schizophrenia Research. 2020 ; Bind 224. s. 151-158.

Bibtex

@article{6cfbd7429ed8474ea747c6c601ece5e2,
title = "Cognitive remediation plus standard treatment versus standard treatment alone for individuals at ultra-high risk of developing psychosis: Results of the FOCUS randomised clinical trial",
abstract = "Background: Individuals at ultra-high risk (UHR) for psychosis have significant cognitive deficits that can impede functional recovery. Applying cognitive remediation (CR) before the onset of frank psychosis may improve the cognitive and functional prognosis of UHR individuals, however, little is known about the feasibility and efficacy of CR for this population.Methods: In this randomised, clinical trial 146 individuals at UHR for psychosis aged 18-40 years were randomly assigned to treatment as usual (TAU) or TAU plus cognitive remediation. The CR targeted neurocognitive and social cognitive remediation. Assessments were carried out at 6- and 12-months post baseline.Results: A total of 73 UHR individuals were assigned to TAU and 73 assigned to TAU + cognitive remediation. Compared to the control group, cognitive remediation did not result in significant improvement on the primary outcome; the Brief Assessment of Cognition in Schizophrenia composite score at 6-month follow-up (b = -0.125, 95%CI: -0.23 to 0.172, p = 0.41). Nor did the intervention improve secondary outcomes in clinical symptoms or functioning. Exploratory analyses found emotion recognition latencies to be significantly more reduced in the intervention group at 6-months. At 12-months, the intervention group exhibited significantly better performance on two measures of executive function and visual memory.Conclusion: The 20-session treatment protocol was not well received in the UHR group, and unsurprisingly global measures did not improve. The benefit found in isolated neuro- and social cognitive measures after even a few sessions points to a potential for cognitive malleability if people can be engaged sufficiently to practice the skills. (C) 2020 Elsevier B.V. All rights reserved.",
keywords = "Cognitive remediation, Cognitive rehabilitation, Ultra-high risk, Clinical high risk, Early intervention",
author = "Glenthoj, {Louise B.} and Mariegaard, {Lise S.} and Birgitte Fagerlund and Jepsen, {Jens R. M.} and Kristensen, {Tina D.} and Christina Wenneberg and Kristine Krakauer and Alice Medalia and Roberts, {David L.} and Carsten Hjorthoj and Merete Nordentoft",
year = "2020",
doi = "10.1016/j.schres.2020.08.016",
language = "English",
volume = "224",
pages = "151--158",
journal = "Schizophrenia Research",
issn = "0920-9964",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Cognitive remediation plus standard treatment versus standard treatment alone for individuals at ultra-high risk of developing psychosis

T2 - Results of the FOCUS randomised clinical trial

AU - Glenthoj, Louise B.

AU - Mariegaard, Lise S.

AU - Fagerlund, Birgitte

AU - Jepsen, Jens R. M.

AU - Kristensen, Tina D.

AU - Wenneberg, Christina

AU - Krakauer, Kristine

AU - Medalia, Alice

AU - Roberts, David L.

AU - Hjorthoj, Carsten

AU - Nordentoft, Merete

PY - 2020

Y1 - 2020

N2 - Background: Individuals at ultra-high risk (UHR) for psychosis have significant cognitive deficits that can impede functional recovery. Applying cognitive remediation (CR) before the onset of frank psychosis may improve the cognitive and functional prognosis of UHR individuals, however, little is known about the feasibility and efficacy of CR for this population.Methods: In this randomised, clinical trial 146 individuals at UHR for psychosis aged 18-40 years were randomly assigned to treatment as usual (TAU) or TAU plus cognitive remediation. The CR targeted neurocognitive and social cognitive remediation. Assessments were carried out at 6- and 12-months post baseline.Results: A total of 73 UHR individuals were assigned to TAU and 73 assigned to TAU + cognitive remediation. Compared to the control group, cognitive remediation did not result in significant improvement on the primary outcome; the Brief Assessment of Cognition in Schizophrenia composite score at 6-month follow-up (b = -0.125, 95%CI: -0.23 to 0.172, p = 0.41). Nor did the intervention improve secondary outcomes in clinical symptoms or functioning. Exploratory analyses found emotion recognition latencies to be significantly more reduced in the intervention group at 6-months. At 12-months, the intervention group exhibited significantly better performance on two measures of executive function and visual memory.Conclusion: The 20-session treatment protocol was not well received in the UHR group, and unsurprisingly global measures did not improve. The benefit found in isolated neuro- and social cognitive measures after even a few sessions points to a potential for cognitive malleability if people can be engaged sufficiently to practice the skills. (C) 2020 Elsevier B.V. All rights reserved.

AB - Background: Individuals at ultra-high risk (UHR) for psychosis have significant cognitive deficits that can impede functional recovery. Applying cognitive remediation (CR) before the onset of frank psychosis may improve the cognitive and functional prognosis of UHR individuals, however, little is known about the feasibility and efficacy of CR for this population.Methods: In this randomised, clinical trial 146 individuals at UHR for psychosis aged 18-40 years were randomly assigned to treatment as usual (TAU) or TAU plus cognitive remediation. The CR targeted neurocognitive and social cognitive remediation. Assessments were carried out at 6- and 12-months post baseline.Results: A total of 73 UHR individuals were assigned to TAU and 73 assigned to TAU + cognitive remediation. Compared to the control group, cognitive remediation did not result in significant improvement on the primary outcome; the Brief Assessment of Cognition in Schizophrenia composite score at 6-month follow-up (b = -0.125, 95%CI: -0.23 to 0.172, p = 0.41). Nor did the intervention improve secondary outcomes in clinical symptoms or functioning. Exploratory analyses found emotion recognition latencies to be significantly more reduced in the intervention group at 6-months. At 12-months, the intervention group exhibited significantly better performance on two measures of executive function and visual memory.Conclusion: The 20-session treatment protocol was not well received in the UHR group, and unsurprisingly global measures did not improve. The benefit found in isolated neuro- and social cognitive measures after even a few sessions points to a potential for cognitive malleability if people can be engaged sufficiently to practice the skills. (C) 2020 Elsevier B.V. All rights reserved.

KW - Cognitive remediation

KW - Cognitive rehabilitation

KW - Ultra-high risk

KW - Clinical high risk

KW - Early intervention

U2 - 10.1016/j.schres.2020.08.016

DO - 10.1016/j.schres.2020.08.016

M3 - Journal article

C2 - 32873460

VL - 224

SP - 151

EP - 158

JO - Schizophrenia Research

JF - Schizophrenia Research

SN - 0920-9964

ER -

ID: 255099360