Coarse and fine particles but not ultrafine particles in urban air trigger hospital admission for asthma in children
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Coarse and fine particles but not ultrafine particles in urban air trigger hospital admission for asthma in children. / Iskandar, Amne; Andersen, Zorana Jovanovic; Bønnelykke, Klaus; Ellermann, Thomas; Andersen, Klaus Kaae; Bisgaard, Hans.
I: Thorax, Bind 67, Nr. 3, 03.2012, s. 252-7.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Coarse and fine particles but not ultrafine particles in urban air trigger hospital admission for asthma in children
AU - Iskandar, Amne
AU - Andersen, Zorana Jovanovic
AU - Bønnelykke, Klaus
AU - Ellermann, Thomas
AU - Andersen, Klaus Kaae
AU - Bisgaard, Hans
PY - 2012/3
Y1 - 2012/3
N2 - BackgroundShort-term exposure to air pollution can trigger hospital admissions for asthma in children, but it is not known which components of air pollution are most important. There are no available studies on the particular effect of ultrafine particles (UFPs) on paediatric admissions for asthma.AimTo study whether short-term exposure to air pollution is associated with hospital admissions for asthma in children. It is hypothesised that (1) the association between asthma admissions and air pollution is stronger with UFPs than with coarse (PM(10)) and fine (PM(2.5)) particles, nitrogen oxides (NO(x)) or nitrogen dioxide (NO(2)); and (2) infants are more susceptible to the effects of exposure to air pollution than older children.MethodDaily counts of admissions for asthma in children aged 0-18 years to hospitals located within a 15 km radius of the central fixed background urban air pollution measurement station in Copenhagen between 2001 and 2008 were extracted from the Danish National Patient Registry. A time-stratified case crossover design was applied and data were analysed using conditional logistic regression to estimate the effect of air pollution on asthma admissions.ResultsA significant association was found between hospital admissions for asthma in children aged 0-18 years and NO(x) (OR 1.11; 95% CI 1.05 to 1.17), NO(2) (1.10; 95% CI 1.04 to 1.16), PM(10) (1.07; 95% CI 1.03 to 1.12) and PM(2.5) (1.09; 95% CI 1.04 to 1.13); there was no association with UFPs. The association was stronger in infants than in older children for all pollutants, but no statistically significant interaction was detected.ConclusionShort-term exposure to air pollution can trigger hospital admission for asthma in children, with infants possibly being most susceptible. These effects seemed to be mediated by larger particles and traffic-related gases, whereas UFPs showed no effect.
AB - BackgroundShort-term exposure to air pollution can trigger hospital admissions for asthma in children, but it is not known which components of air pollution are most important. There are no available studies on the particular effect of ultrafine particles (UFPs) on paediatric admissions for asthma.AimTo study whether short-term exposure to air pollution is associated with hospital admissions for asthma in children. It is hypothesised that (1) the association between asthma admissions and air pollution is stronger with UFPs than with coarse (PM(10)) and fine (PM(2.5)) particles, nitrogen oxides (NO(x)) or nitrogen dioxide (NO(2)); and (2) infants are more susceptible to the effects of exposure to air pollution than older children.MethodDaily counts of admissions for asthma in children aged 0-18 years to hospitals located within a 15 km radius of the central fixed background urban air pollution measurement station in Copenhagen between 2001 and 2008 were extracted from the Danish National Patient Registry. A time-stratified case crossover design was applied and data were analysed using conditional logistic regression to estimate the effect of air pollution on asthma admissions.ResultsA significant association was found between hospital admissions for asthma in children aged 0-18 years and NO(x) (OR 1.11; 95% CI 1.05 to 1.17), NO(2) (1.10; 95% CI 1.04 to 1.16), PM(10) (1.07; 95% CI 1.03 to 1.12) and PM(2.5) (1.09; 95% CI 1.04 to 1.13); there was no association with UFPs. The association was stronger in infants than in older children for all pollutants, but no statistically significant interaction was detected.ConclusionShort-term exposure to air pollution can trigger hospital admission for asthma in children, with infants possibly being most susceptible. These effects seemed to be mediated by larger particles and traffic-related gases, whereas UFPs showed no effect.
KW - Adolescent
KW - Age Factors
KW - Asthma
KW - Child
KW - Child, Preschool
KW - Cross-Over Studies
KW - Denmark
KW - Environmental Monitoring
KW - Epidemiological Monitoring
KW - Hospitalization
KW - Humans
KW - Infant
KW - Infant, Newborn
KW - Nitrogen Dioxide
KW - Nitrogen Oxides
KW - Particle Size
KW - Particulate Matter
KW - Sex Factors
KW - Urban Health
U2 - 10.1136/thoraxjnl-2011-200324
DO - 10.1136/thoraxjnl-2011-200324
M3 - Journal article
C2 - 22156960
VL - 67
SP - 252
EP - 257
JO - Thorax
JF - Thorax
SN - 0040-6376
IS - 3
ER -
ID: 40145003