Clinical usefulness of serum cystatin C and the pertinent estimation of glomerular filtration rate based on cystatin C
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Clinical usefulness of serum cystatin C and the pertinent estimation of glomerular filtration rate based on cystatin C. / Cha, Ran-Hui; Lee, Chung Sik; Lim, Youn-Hee; Kim, Ho; Lee, Seung Hwan; Yu, Kyung Sang; Kim, Yon Su.
I: Nephrology, Bind 15, Nr. 8, 2010, s. 768-76.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Clinical usefulness of serum cystatin C and the pertinent estimation of glomerular filtration rate based on cystatin C
AU - Cha, Ran-Hui
AU - Lee, Chung Sik
AU - Lim, Youn-Hee
AU - Kim, Ho
AU - Lee, Seung Hwan
AU - Yu, Kyung Sang
AU - Kim, Yon Su
N1 - © 2010 The Authors. Nephrology © 2010 Asian Pacific Society of Nephrology.
PY - 2010
Y1 - 2010
N2 - AIM: Although cystatin C has been developed as an alternative marker for estimating glomerular filtration rate (GFR), its clinical use is as yet limited. The significance of cystatin C for differentiating chronic kidney disease (CKD) stages and established cystatin C-based equations estimating GFR were evaluated.METHODS: The fresh frozen serum samples from CKD (n = 119) and healthy volunteers (n = 22) were evaluated. Serum creatinine (sCr) was measured by the kinetic Jaffé method, and recalibrated to the isotope dilution mass spectrometry (IDMS). Cystatin C was measured using a particle-enhanced nephelometric assay.RESULTS: CKD stages were more sensitively differentiated by cystatin C compared to sCr, especially in moderate and severe kidney dysfunction. Sex and body mass index did not affect cystatin C level. Pearson's correlation coefficients of reciprocal of cystatin C, measured and recalibrated sCr compared to systemic inulin clearance (Cl(in) ) were 0.757, 0.734 and 0.709, respectively. We derived novel pertinent equations based on cystatin C (model 1: 1.404 × cystatin C(-0.895) × age(0.006) × weight(1.074) × height(-1.562) × (0.865; if female); model 2: 43.287 × cystatin C(-0.906) × age(0.101) × (0.762; if female)]. Models 1 and 2 showed superior performance in representing systemic Cl(in) than the IDMS Modification of Diet in Renal Disease (MDRD) study equations did (adjusted r(2) = 0.76 and 0.72 for models 1 and 2, and 0.64 and 0.65 for 4 and 6 variable IDMS MDRD equations, respectively).CONCLUSION: Cystatin C reflects kidney dysfunction sensitively, and thus cystatin C-based estimation of GFR could provide a reliable support for clinical practice.
AB - AIM: Although cystatin C has been developed as an alternative marker for estimating glomerular filtration rate (GFR), its clinical use is as yet limited. The significance of cystatin C for differentiating chronic kidney disease (CKD) stages and established cystatin C-based equations estimating GFR were evaluated.METHODS: The fresh frozen serum samples from CKD (n = 119) and healthy volunteers (n = 22) were evaluated. Serum creatinine (sCr) was measured by the kinetic Jaffé method, and recalibrated to the isotope dilution mass spectrometry (IDMS). Cystatin C was measured using a particle-enhanced nephelometric assay.RESULTS: CKD stages were more sensitively differentiated by cystatin C compared to sCr, especially in moderate and severe kidney dysfunction. Sex and body mass index did not affect cystatin C level. Pearson's correlation coefficients of reciprocal of cystatin C, measured and recalibrated sCr compared to systemic inulin clearance (Cl(in) ) were 0.757, 0.734 and 0.709, respectively. We derived novel pertinent equations based on cystatin C (model 1: 1.404 × cystatin C(-0.895) × age(0.006) × weight(1.074) × height(-1.562) × (0.865; if female); model 2: 43.287 × cystatin C(-0.906) × age(0.101) × (0.762; if female)]. Models 1 and 2 showed superior performance in representing systemic Cl(in) than the IDMS Modification of Diet in Renal Disease (MDRD) study equations did (adjusted r(2) = 0.76 and 0.72 for models 1 and 2, and 0.64 and 0.65 for 4 and 6 variable IDMS MDRD equations, respectively).CONCLUSION: Cystatin C reflects kidney dysfunction sensitively, and thus cystatin C-based estimation of GFR could provide a reliable support for clinical practice.
KW - Adult
KW - Aged
KW - Biomarkers/blood
KW - Case-Control Studies
KW - Creatinine/blood
KW - Cystatin C/blood
KW - Female
KW - Glomerular Filtration Rate
KW - Humans
KW - Kidney Failure, Chronic/blood
KW - Korea
KW - Male
KW - Middle Aged
KW - Models, Biological
KW - Renal Insufficiency, Chronic/blood
KW - Sensitivity and Specificity
KW - Severity of Illness Index
U2 - 10.1111/j.1440-1797.2010.01344.x
DO - 10.1111/j.1440-1797.2010.01344.x
M3 - Journal article
C2 - 21175963
VL - 15
SP - 768
EP - 776
JO - Nephrology
JF - Nephrology
SN - 1320-5358
IS - 8
ER -
ID: 230072420