Changes in serum phosphate during β‐blockade in healthy men are not due to changes in the renal handling of phosphate
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Changes in serum phosphate during β‐blockade in healthy men are not due to changes in the renal handling of phosphate. / Kayser, L.; Perrild, H.; Jørgensen, B.; Fogh‐Andersen, N.; Hansen, J. E. Mølholm.
I: Journal of Internal Medicine, Bind 225, Nr. 3, 1989, s. 197-200.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Changes in serum phosphate during β‐blockade in healthy men are not due to changes in the renal handling of phosphate
AU - Kayser, L.
AU - Perrild, H.
AU - Jørgensen, B.
AU - Fogh‐Andersen, N.
AU - Hansen, J. E. Mølholm
PY - 1989
Y1 - 1989
N2 - Abstract. Serum parathyroid hormone (PTH), phosphate, ionized calcium, magnesium, alkaline phosphatase and creatinine and the urinary excretion of phosphate and creatinine were studied after 1 and 3 weeks β‐blockade in 32 young healthy men given either atenolol at 50 mg. metoprolol at 100 mg, propranolol at 80 mg or placebo twice a day. After 1 week treatment serum phosphate (mean (range)) increased in the propranolol‐treated subjects (1.17 (0.99–1.30) to 1.32 (1.08–1.71) mmol l−1 (P = 0.03), minor changes were found in the atenolol and the metoprolol‐treated subjects but not in the placebo group. Serum phosphate was unchanged compared to pretreatment values after 3 weeks. Renal clearance and urinary excretion of phosphate and creatinine was unchanged after both 1 and 3‐weeks treatment. Serum PTH, ionized calcium, magnesium and alkaline phosphatase were unchanged in all groups, whereas serum urate and creatinine increased in the metoprolol‐treated subjects after both 1 and 3 weeks. 1989 Blackwell Publishing Ltd
AB - Abstract. Serum parathyroid hormone (PTH), phosphate, ionized calcium, magnesium, alkaline phosphatase and creatinine and the urinary excretion of phosphate and creatinine were studied after 1 and 3 weeks β‐blockade in 32 young healthy men given either atenolol at 50 mg. metoprolol at 100 mg, propranolol at 80 mg or placebo twice a day. After 1 week treatment serum phosphate (mean (range)) increased in the propranolol‐treated subjects (1.17 (0.99–1.30) to 1.32 (1.08–1.71) mmol l−1 (P = 0.03), minor changes were found in the atenolol and the metoprolol‐treated subjects but not in the placebo group. Serum phosphate was unchanged compared to pretreatment values after 3 weeks. Renal clearance and urinary excretion of phosphate and creatinine was unchanged after both 1 and 3‐weeks treatment. Serum PTH, ionized calcium, magnesium and alkaline phosphatase were unchanged in all groups, whereas serum urate and creatinine increased in the metoprolol‐treated subjects after both 1 and 3 weeks. 1989 Blackwell Publishing Ltd
KW - atenolol
KW - calcium
KW - magnesium
KW - metoprolol
KW - placebo
KW - propranolol
KW - PTH
KW - renal phosphate handling
KW - serum phosphate
U2 - 10.1111/j.1365-2796.1989.tb00063.x
DO - 10.1111/j.1365-2796.1989.tb00063.x
M3 - Journal article
C2 - 2649632
AN - SCOPUS:0024584387
VL - 225
SP - 197
EP - 200
JO - Journal of Internal Medicine
JF - Journal of Internal Medicine
SN - 0955-7873
IS - 3
ER -
ID: 335354164